Next-generation sequencing of translocation renal cell carcinoma reveals novel RNA splicing partners and frequent mutations of chromatin-remodeling genes.

Date publication

août 2014

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MALOUF Gabriel

Tous les auteurs :
Malouf GG, Su X, Yao H, Gao J, Xiong L, He Q, Compérat E, Couturier J, Molinié V, Escudier B, Camparo P, Doss DJ, Thompson EJ, Khayat D, Wood CG, Yu W, Teh BT, Weinstein J, Tannir NM

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/24899691

Résumé

MITF/TFE translocation renal cell carcinoma (TRCC) is a rare subtype of kidney cancer. Its incidence and the genome-wide characterization of its genetic origin have not been fully elucidated.

Mots clés

Apoptosis, Biomarkers, Tumor, genetics, Blotting, Western, Carcinoma, Renal Cell, genetics, Cell Cycle, Cell Proliferation, Chromatin Assembly and Disassembly, genetics, DNA Helicases, genetics, Gene Expression Regulation, Neoplastic, Genome-Wide Association Study, High-Throughput Nucleotide Sequencing, methods, Humans, Immunoenzyme Techniques, Kidney Neoplasms, genetics, Mutation, genetics, Mutation Rate, RNA Splicing, genetics, RNA, Messenger, genetics, RNA-Binding Proteins, genetics, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Trans-Activators, genetics, Translocation, Genetic, genetics, Tumor Cells, Cultured

Référence

Clin. Cancer Res.. 2014 Aug 1;20(15):4129-40