Fiche publication
Date publication
février 2026
Journal
Science immunology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAHRAM Siamak
,
Pr PRETET Jean-Luc
,
Dr CARAPITO Raphaël
Tous les auteurs :
Yatim A, Youssefian L, Idani A, Mourelatos H, Alipour Olyaei N, Habibi L, Peel JN, Gaballa M, Kim C, Lee D, Le Floc'h C, Chan YH, Martin-Fernandez M, Pelletier L, Nakajima K, Fayand A, Momenilandi M, Seeleuthner Y, Chaldebas M, Saeidian AH, Mahmoudi H, Nikbakht N, Deswarte C, Kerrouche N, Sahel H, Parvaneh N, Tamizifar B, Sherkat R, Chanal J, Firooz A, Alizadeh Z, Lorenzo-Diaz L, Mariaggi AA, Ogishi M, Diep A, Hammadi B, Kerrouche N, Rinchai D, Sedighzadeh S, Mehrjooy S, Akrami SM, Lenormand C, Radosavljevic M, Rosain J, Zhang SY, Boisson B, Zhang P, Boisson-Dupuis S, Krueger JG, Prétet JL, Waterboer T, Pourpak Z, Fazlollahi MR, Abel L, Bogunovic D, Shahrooei M, Cobat A, Carapito R, Molitor A, Vahidnezhad H, Béziat V, Bahram S, Jouanguy E, Casanova JL
Lien Pubmed
Résumé
The human integrin lymphocyte function-associated antigen 1 (LFA-1; αLβ2) is broadly expressed on leukocytes and involved in various intercellular adhesions. We report complete LFA-1 deficiency because of inherited αL (CD11a) deficiency in otherwise healthy adults of various ancestries with skin lesions due to commensal papillomaviruses. The patients had no history of invasive infections characteristic of children with inherited deficiency of β2 (CD18), which forms heterodimers with αL, αM (CD11b), αX (CD11c), or αD (CD11d). The development and function of leukocyte subsets are largely preserved in the absence of LFA-1. However, the transendothelial migration of skin-tropic cutaneous lymphocyte antigen (CLA) memory T cells is severely impaired, resulting in their selective sequestration in the blood. Conversely, alternative integrins mediate the extravasation of other leukocytes, including other T cell subsets, to other tissues. Human LFA-1 is required for steady-state T cell homing to the skin and control of papillomaviruses but is otherwise largely redundant. Integrin-mediated T cell compartmentalization is thus essential for organ-selective immune surveillance.
Référence
Sci Immunol. 2026 02 27;11(116):eadz8360
