Fiche publication
Date publication
mars 2026
Journal
Cancer metastasis reviews
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ENTZ-WERLE Natacha
,
Dr MARTIN Sophie
,
Pr NOEL Georges
,
Dr PINEL Sophie
,
Dr BURCKEL Hélène
,
Pr BOURA Cédric
,
Dr FLACHER Vincent
,
Dr DESCHUYTER Marlène
Tous les auteurs :
Deschuyter M, Martin S, Salmanli C, Hubsch C, Vincent A, Meignan S, Furlan A, Cosset E, Burckel H, Noel G, Salzet M, Duhamel M, Raffo-Romero A, Boura C, Pinel S, Coca A, Joud A, Karnoub MA, Chastagner P, Raimbault S, Sudour-Bonnange H, Flacher V, Bernhard C, Entz-Werlé N
Lien Pubmed
Résumé
Pediatric malignant brain tumors (PMBTs) remain among the most common and challenging cancers in children and adolescents, with current therapies often failing to deliver satisfactory outcomes. A major obstacle is their intrinsic and extrinsic resistance mechanisms, underscoring the urgent need for innovative therapeutic strategies and accurate preclinical modeling. Recent advances in organoid-based technologies offer promising tools to mimic PMBTs more faithfully in vitro. These three-dimensional (3D) models can replicate key features of the tumor and its brain-like microenvironment, providing valuable platforms for studying resistant cancer cells and testing novel treatment approaches. This review discusses the relevance of cultured 3D systems, organoids and tumoroids, in pediatric neuro-oncology, emphasizing their role in precision medicine. These models have become essential for dissecting the complex biology and dynamic biological processes of all PMBTs, while bridging clinical challenges with experimental discoveries, ultimately enabling more effective and personalized treatments for young patients.
Mots clés
3D culture, Brain tumors, Cerebroid, Microfluidic, Organoid, Pediatric, Tumoroid
Référence
Cancer Metastasis Rev. 2026 03 3;45(1):
