Fiche publication
Date publication
février 2026
Journal
International journal of pharmaceutics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ANTON Halina
,
Dr COLLOT Mayeul
Tous les auteurs :
Elhassan M, Conzatti G, Anton H, Collot M, Vandamme T, Anton N
Lien Pubmed
Résumé
Water-in-oil-in-water (w/O/W) double emulsions can compartmentalize hydrophilic actives at high aqueous loadings, but osmotic gradients and interfacial transport often drive premature leakage. This remains a key limitation for high-payload hydrophilic formulations exposed to dilution or osmotic shocks during handling, reconstitution, or administration. Here, we engineer wax-shelled, gel-cored w/O/W double emulsions designed under iso-osmotic conditions to combine storage-stable retention at 25°C (fully solid wax state) with temperature-activated permeability at a high internal water fraction (70%). Double emulsions were prepared with a polyacrylate-gelled inner aqueous phase and either liquid oil or semi-crystalline wax as the middle phase, and characterized by confocal microscopy, release assays (NaCl conductimetry and metformin dialysis/UV at 37°C, with additional 25°C datasets for wax systems), Weibull kinetic modelling (and early-time power-law analysis at 25°C), and oscillatory rheology. Iso-osmotic formulation enabled high initial encapsulation and preserved internal compartmentalization. Release profiles revealed two regimes: minimal leakage at low temperature and a marked increase in permeability upon heating, consistent with barrier-controlled transport. Compared with liquid oil, wax systems provided stronger retention but exhibited partial trapping after triggering. Finally, a CaCl/alginate external gelation model coupled to rheology quantified the triggered sol/gel transition and the mechanical response of wax-based double-emulsion assemblies under thermal stimulation and compressive loading.
Mots clés
Double emulsions, High-internal-phase emulsion, Hydrophilic solute controlled release, Osmotic resistance, Solid lipid shell, Temperature-activated permeability
Référence
Int J Pharm. 2026 02 21;:126713
