Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age.

Date publication

décembre 2025

Journal

Frontiers in cardiovascular medicine

Auteurs

Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann

Tous les auteurs :
Oestereicher MA, Ward CS, Schneltzer E, Marschall S, Fuchs H, Gailus-Durner V, Bou About G, Selloum M, Meziane H, Stewart M, Teboul L, Norris C, Pimm D, Kan M, López Gómez F, Wilson R, Monroy M, Pasha S, Zabrodska E, Prochazka J, Pajuelo Reguera D, Nichtova Z, Herault Y, Wells S, Parkinson H, Heaney JD, Sedlacek R, Gao X, Hrabe de Angelis M, Spielmann N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41488462

Résumé

Mouse models play a critical role in cardiology research, offering valuable insights into the molecular mechanisms, genetics, and potential treatments for cardiovascular diseases. However, the ability to transfer findings in mice between studies is limited by the absence of standardized protocols and valid reference values for the assessment of normal cardiac function in mice. This study aims to establish comprehensive transthoracic echocardiography (TTE) reference ranges for mice, particularly focusing on C57BL/6N wild-type controls.

Mots clés

C57BL/6N mouse model, anesthesia effects on cardiac function, cardiovascular phenotyping, mouse cardiac reference ranges, transthoracic echocardiography (TTE)

Référence

Front Cardiovasc Med. 2025 12 19;12:1695034