Measurable residual disease-guided combination of ibrutinib plus venetoclax versus FCR in previously untreated patients with intermediate-risk chronic lymphocytic leukaemia: a phase 2, randomised trial (ERADIC) from the FILO group.

Fiche publication

Date publication

janvier 2026

Journal

EClinicalMedicine

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FEUGIER Pierre , Pr FORNECKER Luc-Matthieu , Pr DELMER Alain , Dr DRENOU Bernard

Tous les auteurs :
Quinquenel A, Letestu R, Le Garff-Tavernier M, Morisset S, Subtil F, Aurran T, Laribi K, Cymbalista F, Lévy V, Simon L, Roos-Weil D, Leblond V, Dilhuydy MS, Tomowiak C, Dartigeas C, Guièze R, Tournilhac O, Ferrant E, de Guibert S, Feugier P, Merabet F, Leprêtre S, Carassou P, Gay J, Hivert B, Fornecker LM, Dupuis J, Molina L, Villemagne B, Cartron G, Drenou B, Mahé B, Benbrahim O, Cahu X, Portois C, Ysebaert L, Nguyen-Khac F, Dahmani A, Quiney C, Rouillé V, Delmer A, Michallet AS

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41502925

Résumé

For chronic lymphocytic leukaemia (CLL) and intermediate risk factors (unmutated and/or 11q deletion and/or complex karyotype; no alteration), the best first-line treatment is unclear. We compared an MRD-guided, fixed-duration ibrutinib-venetoclax (IV) regimen to fludarabine-cyclophosphamide-rituximab (FCR) in this population.