Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature.

Fiche publication

Date publication

juin 2026

Journal

Journal of translational autoimmunity

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BAHRAM Siamak , Dr CARAPITO Raphaël , Dr MUTTER Catherine

Tous les auteurs :
Scherlinger M, Schmauch E, Carapito R, Pichot A, Alsaleh G, Paul N, Molitor A, Lefebvre F, Schmidt-Mutter C, Bahram S, Sibilia J, Georgel P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41552363

Résumé

Pregnancy induces profound immunological adaptations that usually promote tolerance and reduce autoimmune activity. However, women with systemic lupus erythematosus (SLE) remain at increased risk of disease flares and pregnancy complications, whereas rheumatoid arthritis (RA) often improves during gestation. To better understand this divergence, we longitudinally characterized transcriptomic and microRNA (miRNA) changes in circulating monocytes from healthy, RA, and SLE pregnancies.