Sonic hedgehog and Gli1 expression predict outcome in resected pancreatic adenocarcinoma.

Date publication

mars 2015

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BACHELLIER Philippe

Tous les auteurs :
Maréchal R, Bachet JB, Calomme A, Demetter P, Delpero JR, Svrcek M, Cros J, Bardier-Dupas A, Puleo F, Monges G, Hammel P, Louvet C, Paye F, Bachelier P, Le Treut YP, Vaillant JC, Sauvanet A, André T, Salmon I, Devière J, Emile JF, Van Laethem JL

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25552484

Résumé

Aberrant activation of the hedgehog (Hh) pathway is implicated in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis. We investigated the prognostic and predictive value of four Hh signaling proteins and of the tumor stromal density.

Mots clés

Adenocarcinoma, genetics, Adult, Aged, Aged, 80 and over, Biomarkers, metabolism, Carcinoma, Pancreatic Ductal, genetics, Cohort Studies, Female, Follow-Up Studies, Gene Expression, Hedgehog Proteins, genetics, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Grading, Neoplasm Metastasis, Neoplasm Staging, Oncogene Proteins, genetics, Pancreatic Neoplasms, genetics, Patched Receptors, Patched-1 Receptor, Patient Outcome Assessment, Prognosis, Receptors, Cell Surface, genetics, Receptors, G-Protein-Coupled, genetics, Smoothened Receptor, Stromal Cells, metabolism, Trans-Activators, genetics, Zinc Finger Protein GLI1

Référence

Clin Cancer Res. 2015 03 1;21(5):1215-24