Neoadjuvant pembrolizumab with a watch‑and‑wait strategy for localized MSI/dMMR colon cancer: Study protocol for a randomized GERCOR 109 - PRODIGE 84 phase II trial (PREMICES).

Fiche publication

Date publication

novembre 2025

Journal

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Auteurs

Membres identifiés du Cancéropôle Est :
Dr VERNEREY Dewi , Dr VIENOT Angélique

Tous les auteurs :
Lefevre JH, Dubreuil O, Colle R, Tougeron D, Vienot A, Dupré A, Toullec C, Smith D, Guimbaud R, Chibaudel B, Garcia Larnicol ML, Vernerey D, Cohen R,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41276451

Résumé

Microsatellite instability (MSI) or mismatch‑repair deficiency (dMMR) defines a biologically distinct subgroup of colorectal cancers that are highly responsive to immune checkpoint inhibition. Major and complete pathological responses have been observed with neoadjuvant immunotherapy, raising the possibility of avoiding upfront surgery in selected patients.