Fiche publication
Date publication
octobre 2025
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NOEL Georges
,
Dr SCHOTT Roland
,
Dr BENDER Laura
,
Dr LE FEVRE Clara
Tous les auteurs :
Bilski M, Noël G, Smółka K, Kuncewicz K, Kuźnicki W, Feuvret L, Korab K, Peszyńska-Piorun M, Korona P, Baranowska I, Suleja A, Le Fevre C, Schott R, Somme L, Chabli S, Mesny E, Mastroleo F, Kotecha R, Jurkiewicz J, Fijuth J, Jereczek-Fossa BA, Krystkiewicz K, Harat M, Kuncman Ł
Lien Pubmed
Résumé
The 2021 WHO glioma classification integrates molecular profiling, but outcome data for these patients are limited. We retrospectively analyzed 179 patients (median age 53) with WHO 2021-classified gliomas (grade 2: n = 45, grade 3: n = 51, grade 4: n = 83) treated with surgery and radio(chemo)therapy across four centers in Poland and France. Chemotherapy was administered to 74.9% of patients, with a median radiotherapy dose of 60 Gy (range 32.5-80 Gy). IDH1/2 mutations were identified in 55.3% and 1p/19q codeletion in 22.4%. Patients with IDH1/2 mutations had significantly longer progression-free survival (PFS, 7.7 vs. 1.0 years) and overall survival (OS, 8.2 vs. 2.5 years), both p < 0.01. 1p/19q codeletion was associated with prolonged PFS (7.7 vs. 1.6 years, p < 0.01). In grade 3 gliomas, chemotherapy improved PFS (6.8 vs. 3.6 years) and OS (6.9 vs. 3.9 years), both p < 0.01. Leukopenia grade 0-2 correlated with better PFS (3.6 vs. 1.2 years, p = 0.02) and OS (7.2 vs. 3.2 years, p = 0.04). Absolute lymphocyte count ≤ 1 × 10/mm predicted worse OS (5.3 vs. 8.7 years, p = 0.0043). CTV < 127 cm predicted longer OS in grade 4 gliomas (3.2 vs. 1.7 years, p = 0.012). Our findings provide new real-world evidence on survival and prognostic factors in this population, for which contemporary RWE and OS/PFS data remain scarce.
Mots clés
Humans, Glioma, therapy, Middle Aged, Male, Female, Adult, Aged, Prognosis, Brain Neoplasms, therapy, Retrospective Studies, Chemoradiotherapy, methods, Isocitrate Dehydrogenase, genetics, Mutation, World Health Organization, Young Adult, France, Neoplasm Grading, Poland
Référence
Sci Rep. 2025 10 30;15(1):38011
