Association between group B major ABO-incompatible platelet or plasma transfusion and severe allergic reactions: A nationwide haemovigilance analysis suggesting a role for α-gal syndrome. A Biomedical Excellence for Safer Transfusion Collaborative study.

Fiche publication

Date publication

octobre 2025

Journal

Vox sanguinis

Auteurs

Membres identifiés du Cancéropôle Est :
Dr ANGELOT-DELETTRE Fanny

Tous les auteurs :
Malard L, Beuscart C, de Chaisemartin L, de la Taille V, Delettre F, Humbrecht C, Dunbar N, Lecam S, Laperche S, Tiberghien P,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41161810

Résumé

Severe transfusion reactions to group B-incompatible platelets and plasma possibly related to the α-gal syndrome (AGS) have been recently described. AGS is a potentially severe Immunoglobulin E mediated allergy to mammalian meat and meat-derived products associated with tick bites. The involved allergen, galactose-α-1,3-galactose (α-gal), is antigenically similar to the blood group B antigen. To further assess a potential association between AGS and allergic transfusion reactions (ATRs), we comparatively assessed the frequency of ATRs after plasma or platelet concentrate (PC) transfusion in relation to the degree of ABO compatibility between the recipient and the involved blood component in France.