Sirtuin 1 activity in peripheral blood mononuclear cells of patients with osteoporosis.

Date publication

septembre 2014

Journal

Medical science monitor basic research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr HERBEIN Georges , Pr TOUSSIROT Eric

Tous les auteurs :
Godfrin-Valnet M, Khan KA, Guillot X, Prati C, Baud L, Abbas W, Toussirot E, Wendling D, Herbein G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25228047

Résumé

Sirtuin 1 (SIRT1) is a class III histone deacetylase that may play a critical role in several biological functions, including lifespan, stress, and inflammation. Our main objective was to evaluate SIRT1 activity in peripheral blood mononuclear cells (PBMCs) in patients with osteoporosis and to analyze the relationship between the SIRT 1 activity and markers of inflammation and bone remodelling.

Mots clés

Aged, Case-Control Studies, Cell Nucleus, metabolism, Collagen Type I, blood, Female, Humans, Interleukin-6, blood, Leukocytes, Mononuclear, enzymology, Osteoporosis, blood, Peptides, blood, Sirtuin 1, blood

Référence

Med Sci Monit Basic Res. 2014 Sep;20:142-5