Improving Advanced-Line Multiple Myeloma Care: Insights and Real-World Challenges from the EMMY Study.

Fiche publication

Date publication

septembre 2025

Journal

Clinical hematology international

Auteurs

Membres identifiés du Cancéropôle Est :
Dr CAILLOT Denis , Dr SONNTAG Cécile

Tous les auteurs :
Cazaubiel T, Decaux O, Royer B, Caillot D, Bobin A, Belhadj-Merzoug K, Macro M, Vincent L, Perrot A, Mohty M, Karlin L, Jacquet C, Frenzel L, Chalopin T, Sonntag C, Fontan J, Rigaudeau S, Touzeau C, Demarquette H, Chaib A, Santana C, Darre S, Bareau B, Garlantézec R, Hulin C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40978559

Résumé

Managing multiple myeloma (MM) patients receiving advanced (four or more) lines of treatment is a complex challenge. Therefore, real-world data are essential to better understand and address the medical need of this challenging population. We used the EMMY cohort, a French longitudinal real-world study, to describe the characteristics and outcomes of 2127 MM patients receiving advanced-line treatments between 2017 and 2020. A wide variety of treatments were used without a predominant combination showing an evolution over time. Patients exhibited median time to next treatment and overall survival ranging from 7.8 months (95% CI: 6.7-7.8) and 19.4 months (95% CI: 17.4-22.5) in Line 4 (L4) to 4.8 months (95% CI: 3.5-6) and 12.6 months (95% CI: 8.7-16.6) in L8, respectively. The EMMY study provides valuable insights into the real-world application of advanced-line treatments, demonstrating rapid disease progression and poor outcomes in these patients before the novel anti-B-cell maturation antigen (BCMA) directed therapies. These findings highlight the critical need for novel therapies in this population.