Fiche publication
Date publication
septembre 2025
Journal
EBioMedicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MELY Yves
,
Dr RICHERT Ludovic
,
Dr RASSAM Patrice
Tous les auteurs :
Pitiot A, Brandus B, Iserentant G, Rolin C, Servais JY, Fouquenet D, Chesnay A, Richert L, Briard B, Si-Tahar M, Mely Y, Rassam P, Zimmer J, Desoubeaux G, Dervillez X, Seguin-Devaux C
Lien Pubmed
Résumé
Multidrug-resistant Pseudomonas aeruginosa raises major clinical concerns due to its capacity to cause a wide-array of infections in individuals with compromised immune defences and to withstand standard-of-care therapeutic treatments. Antibody-based approaches have proven to be efficient in the treatment of diverse infections. Here we propose an innovative approach harnessing the complement at the surface of bacteria for further killing.
Mots clés
Complement system, FHR1, Immunotherapy, Multidrug resistance, Pseudomonas aeruginosa
Référence
EBioMedicine. 2025 09 16;120:105926
