Détail - canceropole-wordpress

Using Dark Dyes for Fast Super-Resolution Imaging: A Proof-of-Concept Study.

Ghosh S, Barnoin G, Michel BY, Burger A, Mély Y, Richert L

J Phys Chem Lett. 2025 09 19;:10087-10093

Directed-complement killing of Pseudomonas aeruginosa protects against lethal pneumonia.

Pitiot A, Brandus B, Iserentant G, Rolin C, Servais JY, Fouquenet D, Chesnay A, Richert L, Briard B, Si-Tahar M, Mely Y, Rassam P, Zimmer J, Desoubeaux G, Dervillez X, Seguin-Devaux C

EBioMedicine. 2025 09 16;120:105926

Exploring excited-state proton transfer reactions in isothiazologuanosine, an isofunctional fluorescent analogue of guanosine.

Tkach O, Martinez-Fernandez L, Ruiz-Lera AE, Humbert N, Richert L, Dziuba D, Bombarda E, Bourderioux A, Hanser F, Didier P, Tor Y, Improta R, Léonard J, Mély Y

Phys Chem Chem Phys. 2025 09 3;:

Using lipid binding proteins and advanced microscopy to study lipid domains.

Tomishige N, Takahashi K, Pollet B, Richert L, Mély Y, Kobayashi T

Methods Enzymol. 2024 04 10;700:217-234

Tracing endogenous proteins in living cells through electrotransfer of mRNA encoding chromobodies.

Juncker T, Richert L, Masson M, Zuber G, Chatton B, Donzeau M

Biotechnol J. 2024 02;19(2):e2300548

HIV-1 Gag targeting to the plasma membrane reorganizes sphingomyelin-rich and cholesterol-rich lipid domains.

Tomishige N, Bin Nasim M, Murate M, Pollet B, Didier P, Godet J, Richert L, Sako Y, Mély Y, Kobayashi T

Nat Commun. 2023 11 21;14(1):7353

Quantitative live imaging reveals a direct interaction between CD44v6 and MET in membrane domains upon activation with both MET ligands, HGF and internalin B.

Tannoo RM, Richert L, Koschut D, Tomishige N, Treffert SM, Kobayashi T, Mély Y, Orian-Rousseau V

Biochim Biophys Acta Biomembr. 2023 10 2;:184236

The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton.

Rivera Alvarez J, Asselin L, Tilly P, Benoit R, Batisse C, Richert L, Batisse J, Morlet B, Levet F, Schwaller N, Mély Y, Ruff M, Reymann AC, Godin JD

Cell Rep. 2023 07 6;42(7):112744

Assembly dynamics and structure of an aegerolysin, ostreolysin A6.

Yilmaz N, Panevska A, Tomishige N, Richert L, Mély Y, Sepčić K, Greimel P, Kobayashi T

J Biol Chem. 2023 06 19;:104940

V-ATPase modulates exocytosis in neuroendocrine cells through the activation of the ARNO-Arf6-PLD pathway and the synthesis of phosphatidic acid.

Wang Q, Wolf A, Ozkan S, Richert L, Mely Y, Chasserot-Golaz S, Ory S, Gasman S, Vitale N

Front Mol Biosci. 2023 04 7;10:1163545

Thienoguanosine, a unique non-perturbing reporter for investigating rotational dynamics of DNA duplexes and their complexes with proteins.

Grytsyk N, Richert L, Didier P, Dziuba D, Ciaco S, Mazzoleni V, Lequeu T, Mori M, Tor Y, Martinez-Fernandez L, Improta R, Mély Y

Int J Biol Macromol. 2022 07 31;213:210-225

Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop.

Walter RJ, Sonnentag SJ, Munoz-Sagredo L, Merkel M, Richert L, Bunert F, Heneka YM, Loustau T, Hodder M, Ridgway RA, Sansom OJ, Mely Y, Rothbauer U, Schmitt M, Orian-Rousseau V

Cell Death Dis. 2022 Feb 21;13(2):168

Kinetics of protein-assisted nucleic acid interconversion monitored by transient time resolved fluorescence in microfluidic droplets.

Grytsyk N, Cianfarani D, Crégut O, Richert L, Boudier C, Humbert N, Didier P, Mély Y, Léonard J

Nucleic Acids Res. 2021 Aug 27;:

Intermolecular dark resonance energy transfer (DRET): upgrading fluorogenic DNA sensing.

Barnoin G, Shaya J, Richert L, Le HN, Vincent S, Guérineau V, Mély Y, Michel BY, Burger A

Nucleic Acids Res. 2021 Apr 19;:

Suborganellar Localization of Mitochondrial Proteins and Transcripts in Human Cells.

Smirnova A, Richert L, Smirnov A, Mély Y, Tarassov I

Methods Mol Biol. 2021 ;2277:157-173

The use of pore-forming toxins to image lipids and lipid domains.

Tomishige N, Murate M, Didier P, Richert L, Mély Y, Kobayashi T

Methods Enzymol. 2021 ;649:503-542

What makes thienoguanosine an outstanding fluorescent DNA probe?

Kuchlyan J, Martinez-Fernandez L, Mori M, Gavvala K, Ciaco S, Boudier C, Richert L, Didier P, Tor Y, Improta R, Mély Y

J. Am. Chem. Soc.. 2020 Sep 11;:

A molecular tool targeting the base flipping activity of human UHRF1.

Zaayter L, Mori M, Ahmad T, Ashraf W, Boudier C, Kilin V, Gavvala K, Richert L, Eiler S, Ruff M, Botta M, Bronner C, Mousli M, Mely Y

Chemistry. 2019 Jul 19;:

Excited state dynamics of thienoguanosine, an isomorphic highly fluorescent analogue of guanosine.

Martinez-Fernandez L, Gavvala K, Sharma R, Pascal D, Richert L, Segarra Martì J, Mori M, Mely Y, Improta R

Chemistry. 2019 Mar 18;:

Probing Polarity and Heterogeneity of Lipid Droplets in Live Cells Using a Push-Pull Fluorophore.

Collot M, Bou S, Fam TK, Richert L, Mély Y, Danglot L, Klymchenko AS

Anal. Chem.. 2019 Feb 5;91(3):1928-1935

GUV-AP: multifunctional FIJI-based tool for quantitative image analysis of Giant Unilamellar Vesicles.

Sych T, Schubert T, Vauchelles R, Madl J, Omidvar R, Thuenauer R, Richert L, Mély Y, Römer W

Bioinformatics. 2018 Nov 26;:

Quantifying Release from Lipid Nanocarriers by Fluorescence Correlation Spectroscopy.

Bouchaala R, Richert L, Anton N, Vandamme TF, Djabi S, Mély Y, Klymchenko AS

ACS Omega. 2018 Oct 31;3(10):14333-14340

The NC domain of HIV-1 Gag contributes to the interaction of Gag with TSG101.

El Meshri SE, Boutant E, Mouhand A, Thomas A, Larue V, Richert L, Vivet-Boudou V, Mély Y, Tisné C, Muriaux D, de Rocquigny H

Biochim. Biophys. Acta. 2018 Mar 20;1862(6):1421-1431

Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.

Ashraf W, Bronner C, Zaayter L, Ahmad T, Richert L, Alhosin M, Ibrahim A, Hamiche A, Mely Y, Mousli M

J. Exp. Clin. Cancer Res.. 2017 12 21;36(1):188

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

Platet N, Hinkel I, Richert L, Murdamoothoo D, Moufok-Sadoun A, Vanier M, Lavalle P, Gaiddon C, Vautier D, Freund JN, Gross I

Cancer Lett.. 2017 Feb;386:57-64

Fluorescence correlation spectroscopy as a sensitive and useful tool for revealing potential overlaps between the epitopes of monoclonal antibodies on viral particles.

Richert L, Humbert N, Larquet E, Girerd-Chambaz Y, Manin C, Ronzon F, Mély Y

MAbs. 2016 Oct;8(7):1235-1244

Live cell imaging shows hepatocyte growth factor-induced Met dimerization.

Koschut D, Richert L, Pace G, Niemann HH, Mély Y, Orian-Rousseau V

Biochim. Biophys. Acta. 2016 Jul;1863(7 Pt A):1552-8

Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine.

Greiner VJ, Kovalenko L, Humbert N, Richert L, Birck C, Ruff M, Zaporozhets OA, Dhe-Paganon S, Bronner C, Mely Y

Biochemistry. 2015 Sep 23.

Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6.

Volz Y, Koschut D, Matzke-Ogi A, Dietz MS, Karathanasis C, Richert L, Wagner MG, Mély Y, Heilemann M, Niemann HH, Orian-Rousseau V

Biosci. Rep.. 2015 Jun;35(4):

Fluorescence lifetime imaging of membrane lipid order with a ratiometric fluorescent probe.

Kilin V, Glushonkov O, Herdly L, Klymchenko A, Richert L, Mely Y

Biophys J. 2015 May 19;108(10):2521-31

Role of the nucleocapsid domain in HIV-1 Gag oligomerization and trafficking to the plasma membrane: a fluorescence lifetime imaging microscopy investigation.

El Meshri SE, Dujardin D, Godet J, Richert L, Boudier C, Darlix JL, Didier P, Mely Y, de Rocquigny H

J Mol Biol. 2015 Mar 27;427(6 Pt B):1480-94

Investigating the cellular distribution and interactions of HIV-1 nucleocapsid protein by quantitative fluorescence microscopy.

Anton H, Taha N, Boutant E, Richert L, Khatter H, Klaholz B, Ronde P, Real E, de Rocquigny H, Mely Y

PLoS One. 2015 Feb 27;10(2):e0116921

Fluorogenic Squaraine Dimers with Polarity-Sensitive Folding As Bright Far-Red Probes for Background-Free Bioimaging.

Karpenko IA, Collot M, Richert L, Valencia C, Villa P, Mely Y, Hibert M, Bonnet D, Klymchenko AS

J Am Chem Soc. 2014 Dec 29.

Role of the nucleocapsid region in HIV-1 Gag assembly as investigated by quantitative fluorescence-based microscopy.

de Rocquigny H, El Meshri SE, Richert L, Didier P, Darlix JL, Mely Y

Virus Res. 2014 Nov 26;193:78-88

Fluorescent Amino Acid Undergoing Excited State Intramolecular Proton Transfer for Site-Specific Probing and Imaging of Peptide Interactions.

Sholokh M, Zamotaiev OM, Das R, Postupalenko VY, Richert L, Dujardin D, Zaporozhets OA, Pivovarenko VG, Klymchenko AS, Mely Y

J Phys Chem B. 2014 Oct 22.

Collective fluorescence switching of counterion-assembled dyes in polymer nanoparticles.

Reisch A, Didier P, Richert L, Oncul S, Arntz Y, Mely Y, Klymchenko AS

Nat Commun. 2014 Jun 9;5:4089

Osteogenetic properties of electrospun nanofibrous PCL scaffolds equipped with chitosan-based nanoreservoirs of growth factors.

Ferrand A, Eap S, Richert L, Lemoine S, Kalaskar D, Demoustier-Champagne S, Atmani H, Mely Y, Fioretti F, Schlatter G, Kuhn L, Ladam G, Benkirane-Jessel N

Macromol Biosci. 2014 Jan;14(1):45-55

Tuning excited-state proton transfer dynamics of a 3-hydroxychromone dye in supramolecular complexes via host-guest steric compatibility.

Das R, Duportail G, Ghose A, Richert L, Klymchenko A, Chakraborty S, Yesylevskyy S, Mely Y

Phys Chem Chem Phys. 2014 Jan 14;16(2):776-84

APOBEC3G impairs the multimerization of the HIV-1 Vif protein in living cells.

Batisse J, Guerrero SX, Bernacchi S, Richert L, Godet J, Goldschmidt V, Mely Y, Marquet R, de Rocquigny H, Paillart JC

J Virol. 2013 Jun;87(11):6492-506

Site-selective probing of cTAR destabilization highlights the necessary plasticity of the HIV-1 nucleocapsid protein to chaperone the first strand transfer.

Godet J, Kenfack C, Przybilla F, Richert L, Duportail G, Mely Y

Nucleic Acids Res. 2013 May;41(9):5036-48

Detection of apoptosis through the lipid order of the outer plasma membrane leaflet.

Darwich Z, Klymchenko AS, Kucherak OA, Richert L, Mely Y

Biochim Biophys Acta. 2012 Dec;1818(12):3048-54

Protein-protein and protein-membrane associations in the lignin pathway.

Bassard JE, Richert L, Geerinck J, Renault H, Duval F, Ullmann P, Schmitt M, Meyer E, Mutterer J, Boerjan W, De Jaeger G, Mely Y, Goossens A, Werck-Reichhart D

Plant Cell. 2012 Nov;24(11):4465-82

Sensing micelle hydration by proton-transfer dynamics of a 3-hydroxychromone dye: role of the surfactant headgroup and chain length.

Das R, Duportail G, Richert L, Klymchenko A, Mely Y

Langmuir. 2012 May 8;28(18):7147-59

Dipolar 3-methoxychromones as bright and highly solvatochromic fluorescent dyes.

Kucherak OA, Richert L, Mely Y, Klymchenko AS

Phys Chem Chem Phys. 2012 Feb 21;14(7):2292-300

Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer.

Godet J, Ramalanjaona N, Sharma KK, Richert L, de Rocquigny H, Darlix JL, Duportail G, Mely Y

Nucleic Acids Res. 2011 Aug;39(15):6633-45

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