Impact of the 2018 French National College of Gynecologists and Obstetricians recommendations for clinical practice on maternal and neonatal morbidity and mortality in cases of premature rupture of membranes before 32 weeks of amenorrhea at the University

Fiche publication

Date publication

août 2025

Journal

European journal of obstetrics, gynecology, and reproductive biology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr AKLADIOS Chérif

Tous les auteurs :
Collin-Bund V, Vibert F, Pontvianne M, Boudier E, Minella C, Bel S, Lecointre L, Akladios C, Kuhn P, Langer B, Deruelle P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40885129

Résumé

Spontaneous rupture of membranes before 37 weeks of amenorrhea (preterm premature rupture of membranes [pPROM]) is associated with two main complications: prematurity and fetal infection. Biological parameters, particularly C-reactive protein (CRP) levels, were monitored during a continued pregnancy. Group A represented our previous practice, that is, regular CRP monitoring with induced birth or cesarean section after two consecutive levels above 20 mg/L. Group B represented our practice after the publication of the national recommendations and the absence of induced delivery based on an isolated CRP level with no sign of intrauterine infection. This study aimed to assess the effect of these recommendations on neonatal morbidity and mortality rates.