Fiche publication
Date publication
août 2025
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VENKATASAMY Aina
,
Dr NICOLAE Alina
,
Pr AKLADIOS Chérif
Tous les auteurs :
Pavone M, Rebiere L, Lecointre L, Carles E, Tondon C, Van Quyen PL, Seeliger B, Giannarelli D, Lampert T, Bizzarri N, Scambia G, Akladios C, Nicolae A, Querleu D, Venkatasamy A
Lien Pubmed
Résumé
Accurate assessment of lymph node (LN) status is critical in cancer management, particularly in gynecological malignancies. However, preoperative identification of pathological LNs remains a significant challenge with current imaging modalities. Full-field optical coherence tomography (FF-OCT) is a non-invasive microscopic technique based on tissue reflectivity and light interference, providing real-time, high-resolution images in < 10 min, with no tissue preparation or alteration required. Our aim was to evaluate the diagnostic accuracy of FF-OCT in identifying LN metastatic foci measuring ≥ 0.2 mm in gynecological cancers, in an intraoperative setting. Comparative analysis of 80 fresh ex vivo LNs with FF-OCT versus gold standard pathology showed high accuracy (97.6%), sensitivity (92.3%), and specificity (98.2%) of FF-OCT. These results support the suitability of FF-OCT integration into clinical practice for real-time assessment of LN status, thereby improving intraoperative decision making while enabling subsequent routine histological analysis.
Mots clés
Humans, Female, Tomography, Optical Coherence, methods, Lymph Nodes, pathology, Lymphatic Metastasis, diagnostic imaging, Genital Neoplasms, Female, pathology, Middle Aged, Aged, Adult, Microscopy, methods
Référence
Sci Rep. 2025 08 21;15(1):30821
