Fiche publication
Date publication
août 2025
Journal
American journal of epidemiology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BOUVIER Anne-Marie
,
Dr JOOSTE Valérie
,
Pr LEPAGE Côme
Tous les auteurs :
Botta L, Capocaccia R, Bernasconi A, Rossi S, Galceran J, Maso LD, Lepage C, Molinié F, Bouvier AM, Marcos-Gragera R, Vener C, Guevara M, Murray D, Ragusa R, Gatta G, Jooste V, Wg TE
Lien Pubmed
Résumé
Relative survival with the general population as the reference (RS) is commonly used to estimate net survival (NS). However, cancer patients may face an increased risk of non-cancer death compared to cancer-free individuals. We evaluate the impact of considering this relative risk (RR) on NS estimation. First, we compared selected NS values to generated RS under various theoretical scenarios, considering different RR, NS, age at diagnosis, time since diagnosis, and sex. Then, differences between NS and RS for three cancers were analyzed from cure model based estimates using EUROCARE-6 data. We observed differences between RS and the true value of NS, larger for longer time since diagnosis, older patients and higher NS. For head and neck cancer, the smallest differences were for young female patients at 5 years from diagnosis (4%) and the highest (32%) for older patients. For colorectal cancer, differences were <7% for all ages, both sexes, and times since diagnosis and for breast cancer, differences were <5% except for older patients after 5 years. If RR>1, RS underestimates NS. Our findings aim to correctly interpret the differences between RS and NS, and contextualise the possible biases of assuming RS as a proxy for cancer-specific survival.
Mots clés
net survival, population-based cancer registry, relative risk of non-cancer death for cancer patients compared to general population, relative survival
Référence
Am J Epidemiol. 2025 08 19;:
