Fiche publication
Date publication
septembre 2014
Journal
Physical chemistry chemical physics : PCCP
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PICAUD Fabien
Tous les auteurs :
Cabello-Aguilar S, Abou Chaaya A, Picaud F, Bechelany M, Pochat-Bohatier C, Yesylevskyy S, Kraszewski S, Bechelany MC, Rossignol F, Balanzat E, Janot JM, Miele P, Dejardin P, Balme S
Lien Pubmed
Résumé
Detection of a single macromolecule based on the use of artificial nanopores is an attractive and promising field of research. In this work, we report a device based on a 5 nm single nanopore with a high length/diameter ratio, tailored by the track etching and atomic layer deposition techniques. The translocation of neutral polyethylene glycol (PEG) and charged polyethylene glycol-carboxylate (PEG-carboxylate) molecules of low molar masses (200 and 600 g mol(-1)) through this nanodevice was studied. It was shown that charged PEG-carboxylate molecules, which permeate through the pore, promote an unusual blockade of ionic current whereas the neutral PEG molecules do not show such behaviour. The molecular dynamics simulation shows that both neutral and charged PEGs permeate through the nanopore close to its inner surface. The main difference between the two macromolecules is the existence of a structured shell of cations around the charged PEG, which is likely to cause the observed unusual current blockade.
Mots clés
Computer Simulation, Electric Conductivity, Electromagnetic Fields, Materials Testing, Models, Chemical, Models, Molecular, Molecular Weight, Nanopores, ultrastructure, Oxidation-Reduction, radiation effects, Polyethylene Glycols, chemistry
Référence
Phys Chem Chem Phys. 2014 Sep 7;16(33):17883-92
