Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?

Date publication

novembre 2014

Journal

Diabetologia

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MEYRE David

Tous les auteurs :
Sohani ZN, Deng WQ, Pare G, Meyre D, Gerstein HC, Anand SS

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25145545

Résumé

South Asians are up to four times more likely to develop type 2 diabetes than white Europeans. It is postulated that the higher prevalence results from greater genetic risk. To evaluate this hypothesis, we: (1) systematically reviewed the literature for single nucleotide polymorphisms (SNPs) predisposing to type 2 diabetes in South Asians; (2) compared risk estimates, risk alleles and risk allele frequencies of predisposing SNPs between South Asians and white Europeans; and (3) tested the association of novel SNPs discovered from South Asians in white Europeans.

Mots clés

Asian People, Diabetes Mellitus, Type 2, epidemiology, Europe, Genetic Heterogeneity, Genetic Predisposition to Disease, genetics, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, genetics, White People, genetics

Référence

Diabetologia. 2014 11;57(11):2270-81