Fiche publication
Date publication
mai 2015
Journal
BMC genetics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MEYRE David
Tous les auteurs :
Sohani ZN, Meyre D, de Souza RJ, Joseph PG, Gandhi M, Dennis BB, Norman G, Anand SS
Lien Pubmed
Résumé
Advances in genomics technology have led to a dramatic increase in the number of published genetic association studies. Systematic reviews and meta-analyses are a common method of synthesizing findings and providing reliable estimates of the effect of a genetic variant on a trait of interest. However, summary estimates are subject to bias due to the varying methodological quality of individual studies. We embarked on an effort to develop and evaluate a tool that assesses the quality of published genetic association studies. Performance characteristics (i.e. validity, reliability, and item discrimination) were evaluated using a sample of thirty studies randomly selected from a previously conducted systematic review.
Mots clés
Genetic Association Studies, standards, Humans, Meta-Analysis as Topic, Periodicals as Topic, Reproducibility of Results, Research, standards, Software, Web Browser
Référence
BMC Genet. 2015 05 15;16:50
