Obesity genes and risk of major depressive disorder in a multiethnic population: a cross-sectional study.

Date publication

décembre 2015

Journal

The Journal of clinical psychiatry

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MEYRE David

Tous les auteurs :
Samaan Z, Lee YK, Gerstein HC, Engert JC, Bosch J, Mohan V, Diaz R, Yusuf S, Anand SS, Meyre D,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26717541

Résumé

Observational studies have shown a positive association between obesity (body mass index [BMI] ≥ 30 kg/m2) and depression. Around 120 obesity-associated loci have been identified, but genetic variants associated with depression remain elusive. Recently, our team reported that the fat mass and obesity-associated (FTO) gene rs9939609 obesity-risk variant is paradoxically inversely associated with the risk of depression. This finding raises the question as to whether other obesity-associated genetic variants are also associated with depression.

Mots clés

Adult, Aged, American Indian or Alaska Native, genetics, Asian People, genetics, Black People, genetics, Body Mass Index, Comorbidity, Cross-Sectional Studies, Depressive Disorder, Major, epidemiology, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Obesity, epidemiology, Polymorphism, Single Nucleotide, Risk, White People, genetics

Référence

J Clin Psychiatry. 2015 12;76(12):e1611-8