Fiche publication
Date publication
mai 2025
Journal
JHEP reports : innovation in hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VERRIER Eloi
Tous les auteurs :
Fouillé R, Verrier ER, De Meyer A, Verhoye L, Michelet M, Barnault R, Pons C, Diaz O, Rivoire M, Passot G, Steinmann E, Wedemeyer H, Salvetti A, Pavio N, Doceul V, Darteil R, Meuleman P, Durantel D, Lucifora J
Lien Pubmed
Résumé
The liver, and more precisely hepatocytes, can be infected by several hepatotropic viruses, including HBV, HDV, HCV and HEV, with chronic infection leading to end-stage liver diseases. Since no model allowing multi-infections with the four viruses is reported, limited data are available on their interplay as well as on the potential cross-reactivity of antivirals in multi-infection cases. The aim of our study was to set up such a model.
Mots clés
Hepatitis B Virus, Hepatitis C Virus, Hepatitis D Virus, Hepatitis E Virus, broad acting antivirals, drug screening, hepatocytes
Référence
JHEP Rep. 2025 05;7(5):101383
