Fiche publication
Date publication
janvier 2016
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MEYRE David
Tous les auteurs :
Reddon H, Gerstein HC, Engert JC, Mohan V, Bosch J, Desai D, Bailey SD, Diaz R, Yusuf S, Anand SS, Meyre D
Lien Pubmed
Résumé
Physical activity (PA) has been shown to reduce the impact of FTO variation and obesity genetic risk scores (GRS) on BMI. We examined this interaction using a quantitative measure of PA and two adiposity indexes in a longitudinal multi-ethnic study. We analyzed the impact of PA on the association between 14 obesity predisposing variants (analyzed independently and as a GRS) and baseline/follow-up obesity measures in the multi-ethnic prospective cohort EpiDREAM (17423 participants from six ethnic groups). PA was analyzed using basic (low-moderate-high) and quantitative measures (metabolic equivalents (METS)), while BMI and the body adiposity index (BAI) were used to measure obesity. Increased PA was associated with decreased BMI/BAI at baseline/follow-up. FTO rs1421085, CDKAL1 rs2206734, TNNl3K rs1514176, GIPR rs11671664 and the GRS were associated with obesity measures at baseline and/or follow-up. Risk alleles of three SNPs displayed nominal associations with increased (NTRK2 rs1211166, BDNF rs1401635) or decreased (NPC1 rs1805081) basic PA score independently of BMI/BAI. Both basic and quantitative PA measures attenuated the association between FTO rs1421085 risk allele and BMI/BAI at baseline and follow-up. Our results show that physical activity can blunt the genetic effect of FTO rs1421085 on adiposity by 36-75% in a longitudinal multi-ethnic cohort.
Mots clés
Adult, Alleles, Body Mass Index, Ethnicity, genetics, Female, Follow-Up Studies, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Longitudinal Studies, Male, Middle Aged, Motor Activity, Obesity, epidemiology, Patient Outcome Assessment, Polymorphism, Single Nucleotide, Risk
Référence
Sci Rep. 2016 01 4;6:18672
