Eating Behavior, Low-Frequency Functional Mutations in the Melanocortin-4 Receptor (MC4R) Gene, and Outcomes of Bariatric Operations: A 6-Year Prospective Study.

Date publication

août 2016

Journal

Diabetes care

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MEYRE David

Tous les auteurs :
Bonnefond A, Keller R, Meyre D, Stutzmann F, Thuillier D, Stefanov DG, Froguel P, Horber FF, Kral JG

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/27222505

Résumé

Data on the effects of eating behavior and genetics on outcomes of gastrointestinal surgery for diabesity have been sparse, often flawed, and controversial. We aimed to assess long-term outcomes of bariatric operations in patients characterized for eating behavior and rare mutations in the melanocortin-4 receptor (MC4R) gene, which is strongly implicated in energy balance.

Mots clés

Adolescent, Adult, Aged, Bariatric Surgery, adverse effects, Binge-Eating Disorder, etiology, Body Mass Index, Feeding Behavior, Female, Follow-Up Studies, Gene Expression Regulation, Humans, Logistic Models, Male, Middle Aged, Mutation, Obesity, surgery, Prospective Studies, Receptor, Melanocortin, Type 4, genetics, Sequence Analysis, DNA, Weight Loss, genetics, Young Adult

Référence

Diabetes Care. 2016 08;39(8):1384-92