Fiche publication
Date publication
août 2016
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MEYRE David
Tous les auteurs :
Ishola AF, Gerstein HC, Engert JC, Mohan V, Diaz R, Anand SS, Meyre D
Lien Pubmed
Résumé
We investigated the relationship between glycemic status and BMI and its interaction with obesity single-nucleotide polymorphisms (SNPs) in a multi-ethnic longitudinal cohort at high-risk for dysglycemia. We studied 17 394 participants from six ethnicities followed-up for 3.3 years. Twenty-three obesity SNPs were genotyped and an unweighted genotype risk score (GRS) was calculated. Glycemic status was defined using an oral glucose tolerance test. Linear regression models were adjusted for age, sex and population stratification. Normal glucose tolerance (NGT) to dysglycemia transition was associated with baseline BMI and BMI change. Impaired fasting glucose/impaired glucose tolerance to type 2 diabetes transition was associated with baseline BMI but not BMI change. No simultaneous significant main genetic effects and interactions between SNPs/GRS and glycemic status or transition on BMI level and BMI change were observed. Our data suggests that the interplay between glycemic status and BMI trajectory may be independent of the effects of obesity genes. This implies that individuals with different glycemic statuses may be combined together in genetic association studies on obesity traits, if appropriate adjustments for glycemic status are performed. Implementation of population-wide weight management programs may be more beneficial towards individuals with NGT than those at a later disease stage.
Mots clés
Adult, Blood Glucose, Body Mass Index, Diabetes Mellitus, Type 2, genetics, Ethnicity, genetics, Female, Genetic Predisposition to Disease, Glucose Tolerance Test, Glycemic Index, Humans, Linear Models, Longitudinal Studies, Male, Middle Aged, Molecular Epidemiology, Obesity, genetics, Observational Studies as Topic, Polymorphism, Single Nucleotide, Prediabetic State, genetics
Référence
Sci Rep. 2016 08 2;6:30744
