Fiche publication
Date publication
octobre 2016
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MEYRE David
Tous les auteurs :
Lamri A, Bonnefond A, Meyre D, Balkau B, Roussel R, Marre M, Froguel P, Fumeron F,
Lien Pubmed
Résumé
GPR120 (encoded by FFAR4) is a lipid sensor that plays an important role in the control of energy balance. GPR120 is activated by long chain fatty acids (FAs) including omega-3 FAs. In humans, the loss of function p.R270H variant of the gene FFAR4 has been associated with a lower protein activity, an increased risk of obesity and higher fasting plasma glucose levels. The aim of this study was to investigate whether p.R270H interacts with dietary fat intake to modulate the risk of type 2 diabetes (T2D, 198 incident; 368 prevalent cases) and overweight (787 incident and 2891 prevalent cases) in the prospective D.E.S.I.R. study (n = 5,212, 9 years follow-up).
Mots clés
Dietary fat intake, Free fatty acid receptor 4 (FFAR4), G-protein coupled receptor 120 (GPR120), Gene × diet interaction, Longitudinal, Overweight, Type 2 diabetes (T2D)
Référence
Nutr Metab Cardiovasc Dis. 2016 10;26(10):931-6
