Fiche publication
Date publication
décembre 2016
Journal
The journal of physical chemistry letters
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NICOLAI Adrien
,
Dr DELARUE Patrice
,
Pr SENET Patrick
Tous les auteurs :
Nicolaï A, Delarue P, Senet P
Lien Pubmed
Résumé
Proteins are an important class of nanobioparticles with acoustical modes in the sub-THz frequency range. There is considerable interest to measure and establish the role of these acoustical vibrations for biological function. So far, the technique providing the most detailed information about the acoustical modes of proteins is the very recent Extraordinary Acoustic Raman (EAR) spectroscopy. In this technique, proteins are trapped in nanoholes and excited by two optical lasers of slightly different wavelengths producing an electric field at low frequency (<100 GHz). We demonstrate that the acoustical modes of proteins studied by EAR spectroscopy are both infrared- and Raman-active modes, and we provided interpretation of the spectroscopic fingerprints measured at the single-molecule level. A combination of the present calculations with techniques based on the excitation of a single nanobioparticle by an electric field, such as EAR spectroscopy, should provide a wealth of information on the role of molecular dynamics for biological function.
Référence
J Phys Chem Lett. 2016 12 15;7(24):5128-5136
