Dr DELARUE Patrice

Fiche personne

Coordonnées

Laboratoire interdisciplinaire Carnot de Bourgogne
9 avenue Alain Savary
BP 47870
21078 DIJON Cedex

03 80 39 59 48

Territoire

Bourgogne

Statut

Enseignant-Chercheur

Affiliation

Université Bourgogne Europe (UBE)

Laboratoire interdisciplinaire Carnot de Bourgogne - UMR 6303 (ICB)

Équipes/plateformes

Equipe "Nanosciences"

Recherche

Mots clés : Biomarqueurs, protéines chaperons, protéines intrinsèquement désordonnées, enzymes, modélisation moléculaire et simulations numériques, design de novo de protéines par IA, repliement des protéines, interactions protéines/ligands, séquençage de biomarqueurs

Thématique de recherche :

Physique appliquée aux protéines

Expertises :
- Recherche:Chimie
- Recherche:Physique

Publications

Local entropy in proteins.

Senet P, Guzzo A, Delarue P, Laforge C, Maisuradze GG, Heydel JM, Neiers F, Nicolaï A

Chem Sci. 2025 12 16;:

Structural Analysis of the GSTome.

Petiot N, Schwartz M, Delarue P, Senet P, Neiers F, Nicolaï A

Biomolecules. 2024 06 26;14(7):

Significant influence of four highly conserved amino-acids in lipochaperon-active sHsps on the structure and functions of the Lo18 protein.

Bellanger T, da Silva Barreira D, Wien F, Delarue P, Senet P, Rieu A, Neiers F, Varela PF, Combet S, Weidmann S

Sci Rep. 2023 11 3;13(1):19036

Wild-Type -Synuclein and Variants Occur in Different Disordered Dimers and Pre-Fibrillar Conformations in Early Stage of Aggregation.

Guzzo A, Delarue P, Rojas A, Nicolaï A, Maisuradze GG, Senet P

Front Mol Biosci. 2022 06 28;9:910104

Missense Mutations Modify the Conformational Ensemble of the -Synuclein Monomer Which Exhibits a Two-Phase Characteristic.

Guzzo A, Delarue P, Rojas A, Nicolaï A, Maisuradze GG, Senet P

Front Mol Biosci. 2021 11 29;8:786123

Nanopore sensing of single-biomolecules: a new procedure to identify protein sequence motifs from molecular dynamics.

Nicolaï A, Rath A, Delarue P, Senet P

Nanoscale. 2020 11 19;12(44):22743-22753

Curvature and Torsion of Protein Main Chain as Local Order Parameters of Protein Unfolding.

Grassein P, Delarue P, Nicolaï A, Neiers F, Scheraga HA, Maisuradze GG, Senet P

J Phys Chem B. 2020 06 4;124(22):4391-4398

Molecular Dynamics Investigation of Polylysine Peptide Translocation through MoS Nanopores.

Nicolaï A, Barrios Pérez MD, Delarue P, Meunier V, Drndić M, Senet P

J Phys Chem B. 2019 03 14;123(10):2342-2353

Data on the expression of and in Drosophila chemosensory organs after isothiocyanate exposure.

Fraichard S, Gonzalez D, Grassein P, Delarue P, Senet P, Nicolaï A, Chavanne E, Mucher E, Artur Y, Ferveur JF, Heydel JM, Briand L, Neiers F

Data Brief. 2018 10;20:254-257

From a Highly Disordered to a Metastable State: Uncovering Insights of α-Synuclein.

Cote Y, Delarue P, Scheraga HA, Senet P, Maisuradze GG

ACS Chem Neurosci. 2018 05 16;9(5):1051-1065

Statistical Model To Decipher Protein Folding/Unfolding at a Local Scale.

Grassein P, Delarue P, Scheraga HA, Maisuradze GG, Senet P

J Phys Chem B. 2018 04 5;122(13):3540-3549

Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification.

Gonzalez D, Fraichard S, Grassein P, Delarue P, Senet P, Nicolaï A, Chavanne E, Mucher E, Artur Y, Ferveur JF, Heydel JM, Briand L, Neiers F

Insect Biochem Mol Biol. 2018 04;95:33-43

Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease.

Seignez A, Joly AL, Chaumonnot K, Hazoumé A, Sanka M, Marcion G, Boudesco C, Hammann A, Seigneuric R, Jégo G, Ducoroy P, Delarue P, Senet P, Castilla-Llorente C, Solary E, Durey MA, Rubio MT, Hermine O, Kohli E, Garrido C

JCI Insight. 2017 Mar;2(6):e90531

Fingerprints of Conformational States of Human Hsp70 at Sub-THz Frequencies.

Nicolaï A, Barakat F, Delarue P, Senet P

ACS Omega. 2016 12 31;1(6):1067-1074

Theoretical Insights into Sub-Terahertz Acoustic Vibrations of Proteins Measured in Single-Molecule Experiments.

Nicolaï A, Delarue P, Senet P

J Phys Chem Lett. 2016 12 15;7(24):5128-5136

Intrinsic Localized Modes in Proteins.

Nicolaï A, Delarue P, Senet P

Sci Rep. 2015 12 11;5:18128

New Insights into Protein (Un)Folding Dynamics.

Cote Y, Maisuradze GG, Delarue P, Scheraga HA, Senet P

J Phys Chem Lett. 2015 03 19;6(6):1082-6

Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil-based chemotherapy.

Collura A, Lagrange A, Svrcek M, Marisa L, Buhard O, Guilloux A, Wanherdrick K, Dorard C, Taieb A, Saget A, Loh M, Soong R, Zeps N, Platell C, Mews A, Iacopetta B, De Thonel A, Seigneuric R, Marcion G, Chapusot C, Lepage C, Bouvier AM, Gaub MP, Milano G, Selves J, Senet P, Delarue P, Arzouk H, Lacoste C, Coquelle A, Bengrine-Lefevre L, Tournigand C, Lefevre JH, Parc Y, Biard DS, Flejou JF, Garrido C, Duval A

Gastroenterology. 2014 Feb;146(2):401-11.e1.

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