Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study.

Date publication

mars 2017

Journal

Scientific reports

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MEYRE David

Tous les auteurs :
Christie S, Robiou-du-Pont S, Anand SS, Morrison KM, McDonald SD, Paré G, Atkinson SA, Teo KK, Meyre D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28250428

Résumé

The contribution of polymorphisms associated with adult lipids in early life is unknown. We studied 158 adult lipid polymorphisms in 1440 participants (544 children, 544 mothers and 324 fathers) of the Family Atherosclerosis Monitoring In early life (FAMILY) birth cohort. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) measurements were collected at birth, 3 and 5 years of age. Polymorphisms were genotyped using the Illumina Cardio-Metabochip array. Genotype scores (GS) were calculated for TC, HDL-C, LDL-C and TG. Linear and mixed-effects regressions adjusted for sex, age and population stratification were performed. The GS was associated with LDL-C level at 3 and 5 years (β = 0.017 ± 0.003, P = 2.9 × 10; β = 0.020 ± 0.003, P = 5.7 × 10) and from birth to 5 years (β = 0.013 ± 0.003, P = 2.6 × 10). The GS was associated with TC level at 3 and 5 years (β = 0.009 ± 0.002, P = 9.1 × 10; β = 0.009 ± 0.002, P = 7.7 × 10). CETP rs3764261 was associated with the HDL-C level from birth to 5 years (β = 0.064 ± 0.014, P =  7.4 × 10). AMPD3 rs2923084 was associated with the HDL-C level at 5 years (β = 0.096 ± 0.024, P = 9.7 × 10). Known loci associated with blood lipids in adults are associated with TC, LDL-C and HDL-C, but not TG in early life. Genetically predisposed children may benefit from early lipid lowering preventative strategies.

Mots clés

AMP Deaminase, genetics, Adult, Child, Preschool, Cholesterol Ester Transfer Proteins, genetics, Cholesterol, HDL, blood, Cholesterol, LDL, blood, Fathers, Female, Genetic Association Studies, Genotyping Techniques, methods, Humans, Infant, Newborn, Linkage Disequilibrium, Male, Polymorphism, Genetic, Triglycerides, blood

Référence

Sci Rep. 2017 03 6;7(1):68