Genetic contribution to waist-to-hip ratio in Mexican children and adolescents based on 12 loci validated in European adults.

Date publication

janvier 2019

Journal

International journal of obesity (2005)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MEYRE David

Tous les auteurs :
Turcotte M, Abadi A, Peralta-Romero J, Suarez F, Reddon H, Gomez-Zamudio J, Burguete-Garcia AI, Cruz M, Meyre D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29777226

Résumé

The prevalence of abdominal obesity in Mexican children has risen dramatically in the past decade. Genome-wide association studies (GWAS) for waist-to-hip ratio (WHR) performed predominantly in European descent adult  populations have identified multiple single-nucleotide polymorphisms (SNPs) with larger effects in women. The contribution of these SNPs to WHR in non-European children is unknown.

Mots clés

Adolescent, Adult, Body Mass Index, Child, Cross-Sectional Studies, Europe, Female, Gene Frequency, Genetic Loci, Genome-Wide Association Study, Genotype, Humans, Life Style, Male, Mexico, epidemiology, Obesity, Abdominal, epidemiology, Polymorphism, Single Nucleotide, genetics, Prevalence, Waist-Hip Ratio

Référence

Int J Obes (Lond). 2019 01;43(1):13-22