Fine-mapping of 98 obesity loci in Mexican children.

Date publication

janvier 2019

Journal

International journal of obesity (2005)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MEYRE David

Tous les auteurs :
Liu HY, Alyass A, Abadi A, Peralta-Romero J, Suarez F, Gomez-Zamudio J, Audirac A, Parra EJ, Cruz M, Meyre D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29769702

Résumé

Mexico has one of the highest prevalence of childhood obesity in the world. Genome-wide association studies (GWAS) for obesity have identified multiple single-nucleotide polymorphisms (SNPs) in populations of European, East Asian, and African descent. The contribution of these loci to obesity in Mexican children is unclear. We assessed the transferability of 98 obesity loci in Mexican children and fine-mapped the association signals.

Mots clés

Adolescent, Child, Fasting, blood, Female, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, epidemiology, Genome-Wide Association Study, Humans, Life Style, Male, Mexico, epidemiology, Obesity, blood, Polymorphism, Single Nucleotide, genetics, Socioeconomic Factors

Référence

Int J Obes (Lond). 2019 01;43(1):23-32