AGT rs4762 is associated with diastolic blood pressure in Mexicans with diabetic nephropathy.

Fiche publication

Date publication

mars 2021

Journal

Journal of diabetes and its complications

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MEYRE David

Tous les auteurs :
Vázquez-Moreno M, Locia-Morales D, Peralta-Romero J, Sharma T, Meyre D, Cruz M, Flores-Alfaro E, Valladares-Salgado A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33423909

Résumé

Since angiotensinogen has a pivotal role in the renin-angiotensin-aldosterone system, the analysis of polymorphisms of the angiotensinogen (AGT) gene could help explain its potential involvement in hypertension and diabetic nephropathy (DN) pathogenesis. For that reason, we investigated 1) the association of AGT rs4762 with blood pressure (BP) and kidney function-related traits and 2) the interaction effect of AGT rs4762 with DN on BP and kidney function-related traits in 546 Mexican adults with type 2 diabetes (T2D).