A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical trials using the French national healthcare database.

Fiche publication

Date publication

février 2025

Journal

EClinicalMedicine

Auteurs

Membres identifiés du Cancéropôle Est :
Pr AKLADIOS Chérif

Tous les auteurs :
Jochum F, Doll M, Hamy AS, Donval L, Gougis P, Dumas É, Lecointre L, Gaillard T, Reyal F, Lecuru F, Akladios C, Laas E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39867969

Résumé

Randomized clinical trials (RCTs) are fundamental to evidence-based medicine, but their real-world impact on clinical practice often remains unmonitored. Leveraging large-scale real-world data can enable systematic monitoring of RCT effects. We aimed to develop a reproducible framework using real-world data to assess how major RCTs influence medical practice, using two pivotal surgical RCTs in gynaecologic oncology as an example-the LACC (Laparoscopic Approach to Cervical Cancer) and LION (Lymphadenectomy in Ovarian Neoplasms) trials.