Evaluation of waning of IgG antibody responses after rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccines: a modelling study from the PREVAC randomized trial.

Fiche publication

Date publication

décembre 2025

Journal

Emerging microbes & infections

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DABAKUYO-YONLI Sandrine

Tous les auteurs :
Valayer S, Alexandre M, Prague M, Beavogui AH, Doumbia S, Kieh M, Greenwood B, Leigh B, Poupelin M, Schwimmer C, Sow SO, Berry IM, Kuhn JH, Fusco D, Cauwelaert ND, Watson-Jones D, Thiébaut R, Lévy Y, Yazdanpanah Y, Richert L, Lhomme E, ,Aboulhab J, Aguirre-MacKenzie M, Akoo P, Akpa E, Akpata R, Albert S, Ale BM, Alimamy-Bangura S, Andong P, Andrews BC, Anoma S, Atri N, Augier A, Awuondo K, Ayouba A, Badio M, Bagayoko A, Balde A, Balssa J, Bangura LM, Barrington K, Barte de Saint Fare E, Baseler B, Bauder A, Bauduin C, Bawo L, Beavogui AH, Belson M, Ben-Farhat S, Bererd M, Bernaud N, Beyslow T, Biai N, Billioux J, Billouin-Frazier S, Binachon B, Blie J, Bockstal V, Boison P, Bolay F, Boly A, Bonawitz RE, Borg AG, Bosompem S, Bozman C, Brady T, Browne S, Bullis R, Cagniard B, Cahill K, Cai Y, Camara AA, Camara AK, Camara AM, Campagne A, Campion C, Cantan A, Cash J, Chai SP, Chambelin F, Chea M, Chêne G, Choi E, Chouinard M, Chung F, Chung L, Ciancia S, Cisse PN, Cline-Cole E, Colin C, Coller BA, Conde DS, Cone K, Cone K, Connor L, Connor N, Cooper JB, Couffin-Cardiergues S, Coulibaly F, Coulibaly M, Crew P, Dabakuyo-Yonli S, Dabitao D, Damerval T, Davis B, Deen GF, Dekeyster E, Delfraissy JF, Delmas C, Diakite M, Diallo A, Diallo FA, Diallo MS, Diarra A, Diarra S, Diawara O, Dighero-Kemp B, Diop S, Diouf W, Dixit S, Djenabou B, Doepel L, D’Ortenzio E, Doumbia S, Doumbia MM, Douoguih M, Dozier N, Cauwelaert ND, DuChêne A, Duvenhage M, Eckes R, Elliott E, Enria L, Espérou H, Etienne C, Eyler A, Fakoli L, Fallah M, Fauvel MA, Faye S, Fayiah J, Fleck S, Fofana V, Tchos KF, Franklin K, Fusco D, Gaddah A, Gaignet M, Gallagher K, Gardner J, Gichini H, Gozalbes JG, Grandits G, Gray M, Greenwood B, Grobler N, Gross R, Grue L, Grund B, Guindo O, Gupta S, Haidara F, Hamz B, Hancox E, Hébert JC, Hendriks J, Hensley P, Hensley LE, Herpin B, Higgs E, Hilton T, Hneino M, Höeltermann TA, Holley HP, Hoover M, Howard N, Hughes M, Ilo D, Irvine S, Ishola D, Jato Y, Joe M, Johnson M, Kaba AS, Kagan J, Kallon K, Kamara M, Kante M, Katoudi J, Keita CM, Keita S, Keita S, Kennedy SB, Keshinro B, Kiawu H, Kieh M, Killinger B, Kinda M, Kirchoff M, Kocher G, Kodio M, Kohn B, Koivogui L, Kojan R, Koli CF, Koli JS, Kollie D, Kopka S, Koroma B, Kowuor D, Kpayieli-Freeman C, Kwast L, Lacabaratz C, Lacarra B, Lambert L, Lambeth C, Lancrey-javal S, Lane HC, Langba S, Lawal B, Lee AW, Lee S, Lees S, Lefevre A, Leigh B, Lemarcis F, Lévy Y, Levy-Marchal C, Leyssen M, Lhomme E, Liang J, Linga M, Liu K, Lowe B, Lysander J, Mahamadou I, Maljkovic-Berry I, Mambiah M, Manno D, Marchand J, Marron L, Massaquoi MB, Masson L, Matard C, Mazur S, McCullough J, McFadyen K, McLean C, Mercier N, Michavila P, Miller T, Millimouno NP, Miranda A, Mohamed S, Mooney T, Muamba D, Mulbah J, Ndamenyaa RL, Neaton J, Neboua D, Nelson M, Newell K, Nguyen VK, Njie Y, Njoh W, Novotney-Barry A, Onorato M, Onwuchekwa U, Orsega S, Ortega-Perez I, Osborne C, Otieno T, Oulaï D, Patel S, Peart D, Peeters M, Pettitt J, Peiffer-Smadja N, Phillips R, Pierson J, Piot P, Piziali M, Pong S, Postnikova E, Proffitt C, Quach A, Quigley S, Randunu N, Richert L, Rivière P, Robinson C, Roy C, Russell AF, Sahr P, Saliba K, Samai M, Samake S, Sandrus J, Sanogo I, Sarro YS, Sawadogo S, Sayadi S, Schvartz M, Schwimmer C, Secka F, Sharma H, Shelley D, Shobayo B, Siddiqui S, Simon J, Simpson S, Sivahera BM, Slater K, Smolskis M, Smout E, Snowden E, Soutthiphong AA, Sow A, Sow SO, Sow Y, Stirratt M, Stoop J, Subramaniam G, Surugue L, Swales N, Tamba S, Tang C, Tangara C, Tapia MD, Teahton J, Tegli J, Termote M, Thaurignac G, Thiebaut R, Thompson G, Tierney J, Tindanbil D, Tour A, Towalid E, Traina S, Traore A, Tyee T, Vallée D, Vatrinet R, Vincent C, Vogel S, Wallet C, Warren T, Watson-Jones D, Weaver W, Wentworth D, Wesseh C, Whitworth H, Whitworth J, Wiedemann A, Willems W, Wilson B, Wolf J, Wurie A, Yamadjako D, Yaradouno M, Yarmie Q, Yazdanpanah Y, Yu S, Zeggani Z, Zhou H

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39559990

Résumé

rVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination. Data from a large phase 2 randomized double-blind clinical trial (PREVAC) were used to evaluate waning of anti-Ebola virus (EBOV) glycoprotein (GP) antibody concentrations after rVSVΔG-ZEBOV-GP or Ad26.ZEBOV, MVA-BN-Filo vaccination with linear mixed-effect regression models. After a post-vaccination peak, each vaccination strategy was associated with a decrease of anti-EBOV GP antibody concentrations with distinct kinetics, highlighting a less-rapid decline in antibody levels after vaccination by rVSVΔG-ZEBOV-GP. One year after administration of the vaccine, antibody concentrations were higher in children compared to adults for both vaccines, although with different effect sizes: 1.74-fold higher concentrations (95% confidence interval [CI] [1.48; 2.02]) for children 12-17 years old to 3.10-fold higher concentrations (95% CI [2.58; 3.69]) for those 1-4 years old compared to adults for Ad26.ZEBOV, MVA-BN-Filo versus 1.36-fold (95% CI [1.12; 1.61]) to 1.41-fold (95% CI [1.21; 1.62]) higher than these values for adults, with relatively small changes from one age category of children to another, for rVSVΔG-ZEBOV-GP. Antibody concentrations also differed according to geographical location, pre-vaccination antibody concentration, and sex. In combination with knowledge on memory response, characterization of the major determinants of immune response durability of both vaccinations may guide future EVD control protocols. ClinicalTrials.gov identifier: NCT02876328.