Pr DUCA Laurent

Assembly and remodeling of collagen and elastic fibers in pathophysiology: Proteases have the final cut.

Haddou S, David A, Lipinski O, Puertas RD, Maroteaux A, Le Goff C, Moali C, Lecaille F, Duca L

FEBS J. 2026 05 29;:

Minoxidil and nebivolol restore aortic elastic fiber homeostasis in diabetic mice via potassium channel activation.

Henry A, Vanalderwiert L, Oszust F, Wahart A, Carvajal Berrio DA, Brauchle EM, Schenke-Layland K, Brinckmann J, Steenbock H, Debelle L, Six I, Faury G, Jaisson S, Gillery P, Durlarch V, Sartelet H, Maurice P, Bennasroune A, Martiny L, Duca L, Romier B, Blaise S

Front Physiol. 2025 09 18;16:1648727

Xanthohumol Sensitizes Melanoma Cells to Vemurafenib by Lowering Membrane Cholesterol and Increasing Membrane Fluidity.

Devinat M, Thevenard-Devy J, Ghilane F, Devy J, Chazee L, Terryn C, Duca L, Devarenne-Charpentier E, El Btaouri H

Int J Mol Sci. 2025 03 4;26(5):

Exploring aortic stiffness in aging mice: a comprehensive methodological overview.

Vanalderwiert L, Henry A, de Souza E Silva JM, Carvajal-Berrio D, Debelle L, Wahart A, Marzi J, Schenke-Layland K, Faury G, Six I, Schmelzer CEH, Brinckmann J, Steenbock H, Almagro S, Delacoux F, Jaisson S, Gillery P, Maurice P, Sartelet H, Bennasroune A, Duca L, Romier B, Blaise S

Aging (Albany NY). 2024 12 2;null:

GLS2 links glutamine metabolism and atherosclerosis by remodeling artery walls.

Murcy F, Borowczyk C, Gourion-Arsiquaud S, Torrino S, Ouahrouche N, Barouillet T, Dussaud S, Couralet M, Vaillant N, Merlin J, Berquand A, Kaikkonen MU, McClelland RL, Tressel W, Stein J, Thorp EB, Bertero T, Barbry P, Bailly-Maitre B, Gautier EL, Karjalainen MK, Kettunen J, Duca L, Shea S, Yvan-Charvet L

Nat Cardiovasc Res. 2024 11 19;:

METABOLIC SYNDROME-ASSOCIATED MURINE AORTIC WALL STIFFENING IS ASSOCIATED WITH PREMATURE ELASTIC FIBERS AGING.

Vanalderwiert L, Henry A, Wahart A, Carvajal Berrio DA, Brauchle EM, El Kaakour L, Schenke-Layland K, Brinckmann J, Steenbock H, Debelle L, Six I, Faury G, Jaisson S, Gillery P, Durlach V, Sartelet H, Maurice P, Bennasroune A, Martiny L, Duca L, Romier B, Blaise S

Am J Physiol Cell Physiol. 2024 07 1;:

Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo.

Toussaint K, Appert-Collin A, Vanalderwiert L, Bour C, Terryn C, Spenlé C, Van Der Heyden M, Roumieux M, Maurice P, Romier-Crouzet B, Sartelet H, Duca L, Blaise S, Bennasroune A

J Biol Chem. 2024 04 23;:107316

Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1.

Guillot A, Toussaint K, Ebersold L, ElBtaouri H, Thiebault E, Issad T, Peiretti F, Maurice P, Sartelet H, Bennasroune A, Martiny L, Dauchez M, Duca L, Durlach V, Romier B, Baud S, Blaise S

J Physiol Biochem. 2024 02 23;:

A Study on Thiol-Michael Addition to Semi-Synthetic Elastin-Hyaluronan Material for Electrospun Scaffolds.

Laezza A, Pepe A, Solimando N, Armiento F, Oszust F, Duca L, Bochicchio B

Chempluschem. 2024 01 15;:e202300662

Dual inhibitory mechanism of the truncated form of adenylyl cyclase 8 in cell signal integration: Structural and functional approaches.

Legueux-Cajgfinger Y, Velusamy M, Fathallah S, Vallin B, Duca L, Dauchez M, Vincent P, Limon I, Blaise R

Biochim Biophys Acta Mol Cell Res. 2023 11 26;:119645

Pharmacological modulation of vascular ageing: a review from VascAgeNet.

Roth L, Dogan S, Tuna BG, Aranyi T, Benitez S, Borrell-Pages M, Bozaykut P, De Meyer GRY, Duca L, Durmus N, Fonseca D, Fraenkel E, Gillery P, Giudici A, Jaisson S, Johansson M, Julve J, Lucas-Herald AK, Martinet W, Maurice P, McDonnell B, Ozbek EN, Pucci G, Pugh CJA, Rochfort KD, Roks AJM, Rotllan N, Shadiow J, Sohrabi Y, Spronck B, Szeri F, Terentes-Printzios D, Aydın ET, Tura-Ceide O, Ucar E, Anacak GY

Ageing Res Rev. 2023 11 11;:102122

The endocytic receptor protein LRP-1 modulate P-glycoprotein mediated drug resistance in MCF-7 cells.

Henry A, Mauperin M, Devy J, Dedieu S, Chazee L, Hachet C, Terryn C, Duca L, Martiny L, Devarenne-Charpentier E, Btaouri HE

PLoS One. 2023 09 28;18(9):e0285834

Neuraminidase-1: A Sialidase Involved in the Development of Cancers and Metabolic Diseases.

Toussaint K, Appert-Collin A, Morjani H, Albrecht C, Sartelet H, Romier-Crouzet B, Maurice P, Duca L, Blaise S, Bennasroune A

Cancers (Basel). 2022 10 5;14(19):

The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases.

Tembely D, Henry A, Vanalderwiert L, Toussaint K, Bennasroune A, Blaise S, Sartelet H, Jaisson S, Galés C, Martiny L, Duca L, Romier-Crouzet B, Maurice P

Front Endocrinol (Lausanne). 2022 ;13:815356

Characterization of novel interactions with membrane NEU1 highlights new regulatory functions for the Elastin Receptor Complex in monocyte interaction with endothelial cells.

Bocquet O, Tembely D, Rioult D, Terryn C, Romier B, Bennasroune A, Blaise S, Sartelet H, Martiny L, Duca L, Maurice P

Cell Biosci. 2021 Dec 13;11(1):206

Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall.

Romier B, Dray C, Vanalderwiert L, Wahart A, Hocine T, Dortignac A, Garbar C, Garbar C, Boulagnon C, Bouland N, Maurice P, Bennasroune A, Sartelet H, Martiny L, Duca L, Valet P, Blaise S

Sci Rep. 2021 Nov 15;11(1):22278

Carbamylation of elastic fibers is a molecular substratum of aortic stiffness.

Doué M, Okwieka A, Berquand A, Gorisse L, Maurice P, Velard F, Terryn C, Molinari M, Duca L, Piétrement C, Gillery P, Jaisson S

Sci Rep. 2021 Sep 8;11(1):17827

Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from L.: A Preliminary Study.

Albrecht C, Akissi ZLE, Yao-Kouassi PA, Alabdul Magid A, Maurice P, Duca L, Voutquenne-Nazabadioko L, Bennasroune A

Biomedicines. 2021 Apr 11;9(4):

A Guide to the Composition and Functions of the Extracellular Matrix.

Karamanos NK, Theocharis AD, Piperigkou Z, Manou D, Passi A, Skandalis SS, Vynios DH, Orian-Rousseau V, Ricard-Blum S, Schmelzer CEH, Duca L, Durbee M, Afratis NA, Troeberg L, Franchi M, Masola V, Onisto M

FEBS J. 2021 Feb 19;:

Revealing the elasticity of an individual aortic fiber during ageing at nanoscale by atomic force microscopy.

Berquand A, Wahart A, Henry A, Gorisse L, Maurice P, Blaise S, Romier-Crouzet B, Pietrement C, Bennasroune A, Sartelet H, Jaisson S, Gillery P, Martiny L, Touré F, Duca L, Molinari M

Nanoscale. 2021 Jan 5;:

Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation.

Hocine T, Blaise S, Hachet C, Guillot A, Sartelet H, Maurice P, Bennasroune A, Martiny L, Duca L, Romier-Crouzet B, El Btaouri H

J. Physiol. Biochem.. 2020 Jun 26;:

Thrombospondin-1 Receptor CD47 Overexpression Contributes to P-Glycoprotein-Mediated Multidrug Resistance Against Doxorubicin in Thyroid Carcinoma FTC-133 Cells.

Courageot MP, Duca L, Martiny L, Devarenne-Charpentier E, Morjani H, El Btaouri H

Front Oncol. 2020 ;10:551228

Transmembrane Peptides as a New Strategy to Inhibit Neuraminidase-1 Activation.

Albrecht C, Kuznetsov AS, Appert-Collin A, Dhaideh Z, Callewaert M, Bershatsky YV, Urban AS, Bocharov EV, Bagnard D, Baud S, Blaise S, Romier-Crouzet B, Efremov RG, Dauchez M, Duca L, Gueroult M, Maurice P, Bennasroune A

Front Cell Dev Biol. 2020 ;8:611121

Transmembrane Peptides as Inhibitors of Protein-Protein Interactions: An Efficient Strategy to Target Cancer Cells?

Albrecht C, Appert-Collin A, Bagnard D, Blaise S, Romier-Crouzet B, Efremov RG, Sartelet H, Duca L, Maurice P, Bennasroune A

Front Oncol. 2020 ;10:519

Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage.

Bennasroune A, Romier-Crouzet B, Blaise S, Laffargue M, Efremov RG, Martiny L, Maurice P, Duca L

Matrix Biol.. 2019 Jun 18;:

Role of Elastin Peptides and Elastin Receptor Complex in metabolic and cardiovascular diseases.

Wahart A, Hocine T, Albrecht C, Henry A, Sarazin T, Martiny L, Btaouri HE, Maurice P, Bennasroune A, Romier-Crouzet B, Blaise S, Duca L

FEBS J.. 2019 Apr 4;:

Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex.

Kawecki C, Bocquet O, Schmelzer CEH, Heinz A, Ihling C, Wahart A, Romier B, Bennasroune A, Blaise S, Terryn C, Linton KJ, Martiny L, Duca L, Maurice P

Cell. Mol. Life Sci.. 2018 Nov 29;:

Elastin molecular aging promotes MDA-MB-231 breast cancer cell invasiveness.

Salesse S, Odoul L, Chazée L, Garbar C, Duca L, Martiny L, Mahmoudi R, Debelle L

FEBS Open Bio. 2018 Sep;8(9):1395-1404

Novel short isoforms of adenylyl cyclase as negative regulators of cAMP production.

Vallin B, Legueux-Cajgfinger Y, Clément N, Glorian M, Duca L, Vincent P, Limon I, Blaise R

Biochim. Biophys. Acta. 2018 Jun 22;:

Production of Elastin-Derived Peptides Contribute to the Development of Non-Alcoholic Steatohepatitis.

Romier B, Ivaldi C, Sartelet H, Heinz A, Schmelzer CEH, Garnotel R, Guillot A, Jonquet J, Bertin E, Guéant JL, Alberto JM, Bronowicki JP, Amoyel J, Hocine T, Duca L, Maurice P, Bennasroune A, Martiny L, Debelle L, Durlach V, Blaise S

Diabetes. 2018 May 25;:

Biological activities of triterpenoids from Poraqueiba sericea stems.

Zebiri I, Haddad M, Duca L, Sauvain M, Paloque L, Cabanillas B, Rengifo E, Behr JB, Voutquenne-Nazabadioko L

Nat. Prod. Res.. 2017 Jun;31(11):1333-1338

New Insights into Molecular Organization of Human Neuraminidase-1: Transmembrane Topology and Dimerization Ability.

Maurice P, Baud S, Bocharova OV, Bocharov EV, Kuznetsov AS, Kawecki C, Bocquet O, Romier B, Gorisse L, Ghirardi M, Duca L, Blaise S, Martiny L, Dauchez M, Efremov RG, Debelle L

Sci Rep. 2016 Dec;6:38363

Impact of sialic acids on the molecular dynamic of bi-antennary and tri-antennary glycans.

Guillot A, Dauchez M, Belloy N, Jonquet J, Duca L, Romier B, Maurice P, Debelle L, Martiny L, Durlach V, Baud S, Blaise S

Sci Rep. 2016 Oct;6:35666

Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana.

Zebiri I, Haddad M, Duca L, Harakat D, Cabanillas B, Paloque L, Scandolera A, Sauvain M, Rengifo E, Voutquenne-Nazabadioko L

Phytochemistry. 2016 Oct;130:262-72

Matrix ageing and vascular impacts: focus on elastin fragmentation.

Duca L, Blaise S, Romier B, Laffargue M, Gayral S, El Btaouri H, Kawecki C, Guillot A, Martiny L, Debelle L, Maurice P

Cardiovasc. Res.. 2016 06;110(3):298-308

A second-generation ferrocene-iminosugar hybrid with improved fucosidase binding properties.

Hottin A, Scandolera A, Duca L, Wright DW, Davies GJ, Behr JB

Bioorg. Med. Chem. Lett.. 2016 Mar;26(6):1546-9

Protein carbamylation is a hallmark of aging.

Gorisse L, Pietrement C, Vuiblet V, Schmelzer CE, Köhler M, Duca L, Debelle L, Fornès P, Jaisson S, Gillery P

Proc. Natl. Acad. Sci. U.S.A.. 2016 Feb;113(5):1191-6

Editorial: Matricellular Receptors As Potential Targets in Anti-Cancer Therapeutic Strategies.

Emonard H, Duca L, Dedieu S

Front Pharmacol. 2016 ;7:95

Saffron extracts alleviate cardiomyocytes injury induced by doxorubicin and ischemia-reperfusion in vitro.

Chahine N, Nader M, Duca L, Martiny L, Chahine R

Drug Chem Toxicol. 2016 ;39(1):87-96

The Elastin Receptor Complex: A Unique Matricellular Receptor with High Anti-tumoral Potential.

Scandolera A, Odoul L, Salesse S, Guillot A, Blaise S, Kawecki C, Maurice P, El Btaouri H, Romier-Crouzet B, Martiny L, Debelle L, Duca L

Front Pharmacol. 2016 ;7:32

The elastin peptide (VGVAPG)3 induces the 3D reorganisation of PML-NBs and SC35 speckles architecture, and accelerates proliferation of fibroblasts and melanoma cells.

Chatron-Colliet A, Lalun N, Terryn C, Kurdykowski S, Lorenzato M, Rusciani A, Ploton D, Duca L, Bobichon H

Histochem. Cell Biol.. 2015 Mar;143(3):245-58

Uncoupling of Elastin Complex Receptor during In Vitro Aging Is Related to Modifications in Its Intrinsic Sialidase Activity and the Subsequent Lactosylceramide Production.

Scandolera A, Rabenoelina F, Chaintreuil C, Rusciani A, Maurice P, Blaise S, Romier-Crouzet B, El Btaouri H, Martiny L, Debelle L, Duca L

PLoS One. 2015 Jun 18;10(6):e0129994

Elastin-derived peptides are new regulators of thrombosis.

Kawecki C, Hezard N, Bocquet O, Poitevin G, Rabenoelina F, Kauskot A, Duca L, Blaise S, Romier B, Martiny L, Nguyen P, Debelle L, Maurice P

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2570-8

Cardioprotective effect of saffron extracts against acute doxorubicin toxicity in isolated rabbit hearts submitted to ischemia-reperfusion injury.

Chahine N, Makhlouf H, Duca L, Martiny L, Chahine R

Z Naturforsch C. 2014 Nov-Dec;69(11-12):459-70

Elastin peptides activate extracellular signal-regulated kinase 1/2 via a Ras-independent mechanism requiring both p110gamma/Raf-1 and protein kinase A/B-Raf signaling in human skin fibroblasts.

Duca L, Lambert E, Debret R, Rothhut B, Blanchevoye C, Delacoux F, Hornebeck W, Martiny L, Debelle L

Mol Pharmacol. 2005 Apr;67(4):1315-24

Elastin as a matrikine.

Duca L, Floquet N, Alix AJ, Haye B, Debelle L

Crit Rev Oncol Hematol. 2004 Mar;49(3):235-44.

Annexin A1 processing is associated with caspase-dependent apoptosis in BZR cells.

Debret R, El Btaouri H, Duca L, Rahman I, Radke S, Haye B, Sallenave JM, Antonicelli F

FEBS Lett.. 2003 Jul;546(2-3):195-202

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