Farag MR, Guedeney N, Schwalen F, Zadorovnyj A, Barczyk A, Giret M, Antraygues K, Wang A, Cornu M, Suzanne P, Since M, Voisin-Chiret AS, Dubrez L, Leleu-Chavain N, Kieffer C, Sopkova-de Oliveira Santos J

ChemMedChem. 2024 10 4;:e202400567

From the design of innovative Ti-Pt heterometallic complexes to the development of highly anti-proliferative water-soluble cationic titanocenes.

Trommenschlager A, Mabrouk N, Racoeur C, Godard A, Balan C, Dubrez L, Bettaieb A, Husson J, Le Gendre P, Paul C, Bodio E

Chembiochem. 2024 05 15;:e202400099

Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.

Tencer AH, Yu Y, Causse SZ, Campbell GR, Klein BJ, Xuan H, Cartier J, Miles MA, Gaurav N, Zadoroznyj A, Holt TA, Wen H, Hawkins CJ, Spector SA, Dubrez L, Shi X, Kutateladze TG

Nat Struct Mol Biol. 2023 07 31;:

cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3.

Dumétier B, Zadoroznyj A, Berthelet J, Causse S, Allègre J, Bourgeois P, Cattin F, Racoeur C, Paul C, Garrido C, Dubrez L

Oncogene. 2022 11 18;:

Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network.

Ichim G, Gibert B, Adriouch S, Brenner C, Davoust N, Desagher S, Devos D, Dokudovskaya S, Dubrez L, Estaquier J, Gillet G, Guénal I, Juin PP, Kroemer G, Legembre P, Levayer R, Manon S, Mehlen P, Meurette O, Micheau O, Mignotte B, Nguyen-Khac F, Popgeorgiev N, Poyet JL, Priault M, Ricci JE, Riquet FB, Susin SA, Suzanne M, Vacher P, Walter L, Mollereau B

Biomolecules. 2022 06 28;12(7):

Cytoplasmic and Nuclear Functions of cIAP1.

Zadoroznyj A, Dubrez L

Biomolecules. 2022 Feb 17;12(2):

Endoplasmic Reticulum Chaperones in Viral Infection: Therapeutic Perspectives.

Kohli E, Causse S, Baverel V, Dubrez L, Borges-Bonan N, Demidov O, Garrido C

Microbiol Mol Biol Rev. 2021 Oct 13;:e0003521

IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling.

Dumétier B, Zadoroznyj A, Dubrez L

Cells. 2020 Apr 30;9(5):

Cross Kingdom Immunity: The Role of Immune Receptors and Downstream Signaling in Animal and Plant Cell Death.

Roudaire T, Héloir MC, Wendehenne D, Zadoroznyj A, Dubrez L, Poinssot B

Front Immunol. 2020 ;11:612452

Heat-shock proteins: chaperoning DNA repair.

Dubrez L, Causse S, Borges Bonan N, Dumétier B, Garrido C

Oncogene. 2019 Sep 20;:

Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy.

Gozzi GJ, Gonzalez D, Boudesco C, Dias AMM, Gotthard G, Uyanik B, Dondaine L, Marcion G, Hermetet F, Denis C, Hardy L, Suzanne P, Douhard R, Jego G, Dubrez L, Demidov ON, Neiers F, Briand L, Sopková-de Oliveira Santos J, Voisin-Chiret AS, Garrido C

Cell Death Differ.. 2019 May 8;:

[Unexpected role of IAPs in transcriptional regulation].

Dumétier B, Glorian V, Allègre J, Dubrez L

Med Sci (Paris). 2019 May;35(5):405-407

Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia.

Duplomb L, Rivière J, Jego G, Da Costa R, Hammann A, Racine J, Schmitt A, Droin N, Capron C, Gougerot-Pocidalo MA, Dubrez L, Aral B, Lafon A, Edery P, Ghoumid J, Blair E, El Chehadeh-Djebbar S, Carmignac V, Thevenon J, Guy J, Girodon F, Bastie JN, Delva L, Faivre L, Thauvin-Robinet C, Solary E

J. Mol. Med.. 2019 Mar 7;:

HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells.

Causse SZ, Marcion G, Chanteloup G, Uyanik B, Boudesco C, Grigorash BB, Douhard R, Dias AMM, Dumetier B, Dondaine L, Gozzi GJ, Moussay E, Paggetti J, Mirjolet C, de Thonel A, Dubrez L, Demidov ON, Gobbo J, Garrido C

Oncogene. 2018 Dec 12;:

E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death.

Vuillier C, Lohard S, Fétiveau A, Allègre J, Kayaci C, King LE, Braun F, Barillé-Nion S, Gautier F, Dubrez L, Gilmore AP, Juin PP, Maillet L

EMBO Rep.. 2018 Feb;19(2):234-243

E2F1 binds to the peptide-binding groove within the BIR3 domain of cIAP1 and requires cIAP1 for chromatin binding.

Allègre J, Cartier J, Glorian V, Droin N, Dumetier B, Kayaci C, Berthelet J, Gemble S, Vuillier C, Maillet L, Garrido C, Dubrez L

PLoS ONE. 2018 ;13(10):e0206253

Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation.

Dubrez L

Int J Mol Sci. 2017 Oct 19;18(10):

DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.

Glorian V, Allègre J, Berthelet J, Dumetier B, Boutanquoi PM, Droin N, Kayaci C, Cartier J, Gemble S, Marcion G, Gonzalez D, Boidot R, Garrido C, Michaud O, Solary E, Dubrez L

Cell Death Dis. 2017 May;8(5):e2816