Détail - canceropole-wordpress

Effects of true to life polyethylene terephthalate and polycaprolactone nanoparticles on macrophages under a repeated exposure mode.

Collin-Faure V, Villacorta A, Diemer H, Cianférani S, Marcos R, Hernandez A, Carrière M, Darrouzet E, Rabilloud T

NanoImpact. 2026 02 21;:100615

Toward site-specific characterization of structural perturbations on glycosylated Fc using NMR at natural abundance.

Vibert B, Nguyen S, Henot F, Doyen C, Hernandez-Alba O, Cianférani S, Clavier S, Frances O, Boisbouvier J

J Biomol NMR. 2026 02 17;80(1):5

An integrative structural biology approach reveals the dynamic organization of the R2SP quaternary chaperone complex.

Santo PE, Chagot ME, Gizardin-Fredon H, Ley M, Chenuel T, Deslignière E, Plassart L, Paiva ACF, Sousa PMF, Bertrand E, Charpentier B, Verheggen C, Quinternet M, Meyer P, Bandeiras TM, Cianférani S, Plisson-Chastang C, Manival X

Nat Commun. 2026 02 10;:

Brownotate, a Comprehensive Solution to Generate Protein Sequence Databases for Any Species.

Brown A, Burel A, Cianférani S, Carapito C, Bertile F

Proteomics. 2026 01 6;:e70094

Photoactivatable, Biomimetic Ligand photoMultiTASQ Traps DNA/RNA G‑Quadruplexes and Their Protein Binding Partners.

Raevens S, Danino YM, Desingle C, Rota Sperti F, Pirrotta M, Mazzucotelli L, Letissier L, Hornstein E, Cianferani S, Hernandez-Alba O, Valverde IE, Monchaud D

ACS Bio Med Chem Au. 2025 12 17;5(6):994-1006

New Frontiers in ADC Analysis: Advances in Chromatography, Electrophoresis, and Mass Spectrometry.

Beck A, D'Atri V, Verhoev O, Alez-Martin L, Letissier L, Delobel A, Fleury-Souverain S, François YN, Cianférani S, Gahoual R, Guillarme D, Hernandez-Alba O

AAPS J. 2025 12 10;28(1):34

Mechanism of Inhibition of the MeTC7 Ligand That Covalently Binds to VDR To Reduce PD-L1 Expression.

Castel J, Peluso-Iltis C, Sanchez Dafun A, Silvestri A, Osz J, Khazan N, Yano N, Kim KK, Rowswell-Turner RB, Guiberteau T, Teramoto Y, Miyamoto H, Moore RG, Singh RK, Cianférani S, Rochel N

J Med Chem. 2025 10 22;:

Stoichiometric Antibody-Polymer-Drug Conjugate for Effective Low-Dose Treatment of Breast Cancer.

Lehot V, Lidický O, Most J, Nothisen M, Erb S, Dovgan I, Osypenko A, Koniev O, Kolodych S, Kotrchová L, Chaubet G, Cianférani S, Etrych T, Wagner A

Biomacromolecules. 2025 10 13;:

Deciphering molecular determinants of GPBAR1-Gs protein interactions by HDX-MS and cryo-EM.

Castel J, Botzanowski T, Brooks I, Frechard A, Bey G, Schroeter M, Del Nero E, Debaene F, Ciesielski F, Zeyer D, Cianferani S, Morales R

Sci Rep. 2025 08 26;15(1):31517

Designing New Natural-Mimetic Phosphatidic Acid: a Versatile and Innovative Synthetic Strategy for Glycerophospholipid Research.

Schlichter A, Wolf A, Ferrand T, Cocq A, Riachy L, Vertueux S, Beauvais B, Courvalet M, Henry PJ, Tanguy E, Gonzales L, Ferlet R, Laguerre F, Decraene C, Pellissier A, Sebban M, Sabot C, Jeandel L, Cianférani S, Strub JM, Bénard M, Flon V, Peulon-Agasse V, Cardinael P, Ory S, Gasman S, Renard PY, Montero-Hadjadje M, Vitale N, Sébastien B

Angew Chem Int Ed Engl. 2025 07 8;:e202510412

Identification of uranyl-binding proteins in Arabidopsis thaliana cells exposed to uranium: Insights from a metalloproteomic analysis and characterization of Glycine-Rich RNA-binding protein 7 (GRP7).

Revel BH, Favier A, Martin-Laffon J, Vallet A, Przybyla-Toscano J, Brugière S, Couté Y, Diemer H, Cianférani S, Rabilloud T, Bourguignon J, Brutscher B, Ravanel S, Alban C

J Hazard Mater. 2025 07 7;495:139163

Synthesis, Molecular Docking and Biological Evaluation of A-Ring-Carborane-Vitamin D Analogues.

Otero R, Seoane S, Fernández-Domínguez X, Bourguet M, Cianférani S, Peluso-Iltis C, Maestro MA, Pérez-Fernández R, Rochel N, Mouriño A

Molecules. 2025 06 18;30(12):

Development of Top-Down Mass Spectrometry Strategies in the Chromatographic Time Scale (LC-TD-MS) for the Extended Characterization of an Anti-EGFR Single-Domain Antibody-Drug Conjugate in Both Reduced and Nonreduced Forms.

Benazza R, Letissier L, Papadakos G, Thom J, Diemer H, Cotton G, Cianférani S, Hernandez-Alba O

Anal Chem. 2025 01 31;:

The ISC machinery assembles [2Fe-2S] clusters by formation and fusion of [1Fe-1S] precursors.

Gervason S, Dutkiewicz R, Want K, Benazza R, Mor-Gautier R, Grabinska-Rogala A, Sizun C, Hernandez-Alba O, Cianferani S, Guigliarelli B, Burlat B, D'Autréaux B

Nat Chem Biol. 2025 01 27;:

Antibody-Vincristine Conjugates as Potent Anticancer Therapeutic Agents.

Boos A, Most J, Cahuzac H, Moreira da Silva L, Daubeuf F, Erb S, Cianférani S, Hernandez-Alba O, Semenchenko C, Dovgan I, Kolodych S, Detappe A, Dantzer F, Wagner A, Zeniou M, Chaubet G

J Med Chem. 2024 12 16;:

Remodelling of Rea1 linker domain drives the removal of assembly factors from pre-ribosomal particles.

Busselez J, Koenig G, Dominique C, Klos T, Velayudhan D, Sosnowski P, Marechal N, Crucifix C, Gizardin-Fredon H, Cianferani S, Albert B, Henry Y, Henras AK, Schmidt H

Nat Commun. 2024 11 27;15(1):10309

Therapeutic Monoclonal Antibody─Antidrug Antibody Affinity Constant Determination Using Capillary Electrophoresis-Tandem Mass Spectrometry.

Reinert T, Houzé P, Mignet N, Naghizade A, Alez-Martin L, Hernandez-Alba O, Leclerc A, Cianferani S, Gahoual R, Francois YN

Anal Chem. 2024 11 27;:

The HSP90/R2TP quaternary chaperone scaffolds assembly of the TSC complex.

Abéza C, Busse P, Paiva ACF, Chagot ME, Schneider J, Robert MC, Vandermoere F, Schaeffer C, Charpentier B, M F Sousa P, Bandeiras TM, Manival X, Cianferani S, Bertrand E, Verheggen C

J Mol Biol. 2024 10 26;:168840

Supramolecular Bioconjugation Strategy for Antibody-Targeted Delivery of siRNA.

Ripoll M, Cahuzac H, Dovgan I, Ursuegui S, Neuberg P, Erb S, Cianférani S, Kichler A, Remy JS, Wagner A

Bioconjug Chem. 2024 09 25;:

Modular Semisynthetic Approach to Generate T Cell-Dependent Bispecific Constructs from Recombinant IgG1 Antibodies.

Shajan I, Rochet LNC, Tracey SR, Benazza R, Jackowska B, Hernandez-Alba O, Cianférani S, Scott CJ, van Delft FL, Chudasama V, Albada B

Bioconjug Chem. 2024 09 16;:

O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts.

Very N, Boulet C, Gheeraert C, Berthier A, Johanns M, Bou Saleh M, Guille L, Bray F, Strub JM, Bobowski-Gerard M, Zummo FP, Vallez E, Molendi-Coste O, Woitrain E, Cianférani S, Montaigne D, Ntandja-Wandji LC, Dubuquoy L, Dubois-Chevalier J, Staels B, Lefebvre P, Eeckhoute J

Cell Death Dis. 2024 06 3;15(6):391

Chemical Production of Cytotoxic Bispecific Antibodies Using the Ugi Multicomponent Reaction.

Vaur V, Koutsopetras I, Erb S, Jackowska B, Benazza R, Cahuzac H, Detappe A, Hernandez-Alba O, Cianférani S, Scott CJ, Chaubet G

Chembiochem. 2024 05 7;:e202400170

Denaturing mass photometry for rapid optimization of chemical protein-protein cross-linking reactions.

Gizardin-Fredon H, Santo PE, Chagot ME, Charpentier B, Bandeiras TM, Manival X, Hernandez-Alba O, Cianférani S

Nat Commun. 2024 04 25;15(1):3516

Proteomic Profiling of Antimalarial Plasmodione Using 3-Benz(o)ylmenadione Affinity-Based Probes.

Iacobucci I, Monaco V, Hovasse A, Dupouy B, Keumoe R, Cichocki B, Elhabiri M, Meunier B, Strub JM, Monti M, Cianférani S, Blandin SA, Schaeffer-Reiss C, Davioud-Charvet E

Chembiochem. 2024 04 19;:e202400187

Regulations of mitoNEET by the key redox homeostasis molecule glutathione.

Mons C, Salameh M, Botzanowski T, Clémancey M, Dorlet P, Vallières C, Erb S, Vernis L, Guittet O, Lepoivre M, Huang ME, Cianferani S, Latour JM, Blondin G, Golinelli-Cohen MP

J Inorg Biochem. 2024 03 20;255:112535

Targeted delivery of immune-stimulating bispecific RNA, inducing apoptosis and anti-tumor immunity in cancer cells.

Rady T, Erb S, Deddouche-Grass S, Morales R, Chaubet G, Cianférani S, Basse N, Wagner A

iScience. 2024 03 15;27(3):109068

Solution and Solvent-Free Stopper Exchange Reactions for the Preparation of Pillar[5]arene-Containing [2] and [3]Rotaxanes.

Becharguia N, Nierengarten I, Strub JM, Cianférani S, Rémy M, Wasielewski E, Abidi R, Nierengarten JF

Chemistry. 2024 01 31;:e202400246

SEC-MS in denaturing conditions (dSEC-MS) for in-depth analysis of rebridged monoclonal antibody-based formats.

Benazza R, Koutsopetras I, Vaur V, Chaubet G, Hernandez-Alba O, Cianférani S

Talanta. 2024 01 29;272:125727

Solution and Solvent-Free Stopper Exchange Reactions for the Preparation of Pillar[5]arene-containing [2] and [3]Rotaxanes.

Becharguia N, Nierengarten I, Strub JM, Cianférani S, Rémy M, Wasielewski E, Abidi R, Nierengarten JF

Chemistry. 2024 01 2;:e202304131

Subcutaneous Administration of a Zwitterionic Chitosan-Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies.

Gréa T, Jacquot G, Durand A, Mathieu C, Gasser A, Zhu C, Banerjee M, Hucteau E, Mallard J, Lopez Navarro P, Popescu BV, Thomas E, Kryza D, Sidi-Boumedine J, Ferrauto G, Gianolio E, Fleith G, Combet J, Brun S, Erb S, Cianferani S, Charbonnière LJ, Fellmann L, Mirjolet C, David L, Tillement O, Lux F, Harlepp S, Pivot X, Detappe A

Adv Mater. 2023 12 17;:e2308738

Influence of pneumatic transportation on the stability of monoclonal antibodies.

Coliat P, Erb S, Diemer H, Karouby D, Martin T, Banerjee M, Zhu C, Demarchi M, Cianférani S, Detappe A, Pivot X

Sci Rep. 2023 12 10;13(1):21875

Site-Selective Protein Conjugation by a Multicomponent Ugi Reaction.

Koutsopetras I, Vaur V, Benazza R, Diemer H, Sornay C, Ersoy Y, Rochet L, Longo C, Hernandez-Alba O, Erb S, Detappe A, Skerra A, Wagner A, Cianferani S, Chaubet G

Chemistry. 2023 12 5;:e202303242

Improved characterization of trastuzumab deruxtecan with PTCR and internal fragments implemented in middle-down MS workflows.

Beaumal C, Deslignière E, Diemer H, Carapito C, Cianférani S, Hernandez-Alba O

Anal Bioanal Chem. 2023 11 27;:

Rapid Access to Potent Bispecific T Cell Engagers Using Biogenic Tyrosine Click Chemistry.

Shajan I, Rochet LNC, Tracey SR, Jackowska B, Benazza R, Hernandez-Alba O, Cianférani S, Scott CJ, van Delft FL, Chudasama V, Albada B

Bioconjug Chem. 2023 11 14;:

Reinvestigation of the Automated Synthesis of Stoichiometrically Conjugated Antibodies to Access High Molecular Weight Payloads and Multiplexed Conjugation via an In-Solution Trans-Tagging Process.

Lehot V, Lidický O, Most J, Erb S, Dovgan I, Osypenko A, Koniev O, Kolodych S, Kotrchová L, Chaubet G, Cianférani S, Etrych T, Wagner A

ACS Omega. 2023 10 31;8(43):40508-40516

Cysteine-Cysteine Cross-Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine-Electrophilic Reagent.

Koutsopetras I, Mishra AK, Benazza R, Hernandez-Alba O, Cianférani S, Chaubet G, Nicolai S, Waser J

Chemistry. 2023 09 15;:e202302689

Recent advances in structural mass spectrometry methods in the context of biosimilarity assessment: from sequence heterogeneities to higher order structures.

Castel J, Delaux S, Hernandez-Alba O, Cianférani S

J Pharm Biomed Anal. 2023 09 9;236:115696

The interplay between lysosome, protein corona and biological effects of cationic carbon dots: role of surface charge titratability.

Arezki Y, Harmouch E, Delalande F, Rapp M, Schaeffer-Reiss C, Galli O, Cianférani S, Lebeau L, Pons F, Ronzani C

Int J Pharm. 2023 09 6;:123388

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling.

Sartre C, Peurois F, Ley M, Kryszke MH, Zhang W, Courilleau D, Fischmeister R, Ambroise Y, Zeghouf M, Cianferani S, Ferrandez Y, Cherfils J

Nat Commun. 2023 07 12;14(1):4157

Targeted Anticancer Agent with Original Mode of Action Prepared by Supramolecular Assembly of Antibody Oligonucleotide Conjugates and Cationic Nanoparticles.

Lehot V, Neuberg P, Ripoll M, Daubeuf F, Erb S, Dovgan I, Ursuegui S, Cianférani S, Kichler A, Chaubet G, Wagner A

Pharmaceutics. 2023 06 2;15(6):

Bioactivated and PEG-Protected Circa 2 nm Gold Nanoparticles for in Cell Labelling and Cryo-Electron Microscopy.

Groysbeck N, Hanss V, Donzeau M, Strub JM, Cianférani S, Spehner D, Bahri M, Ersen O, Eltsov M, Schultz P, Zuber G

Small Methods. 2023 04 10;:e2300098

Interlaboratory Evaluation of a User-Friendly Benchtop Mass Spectrometer for Multiple-Attribute Monitoring Studies of a Monoclonal Antibody.

Butré CI, D'Atri V, Diemer H, Colas O, Wagner E, Beck A, Cianferani S, Guillarme D, Delobel A

Molecules. 2023 03 22;28(6):

Online Collision-Induced Unfolding of Therapeutic Monoclonal Antibody Glyco-Variants through Direct Hyphenation of Cation Exchange Chromatography with Native Ion Mobility-Mass Spectrometry.

van Schaick G, Domínguez-Vega E, Castel J, Wuhrer M, Hernandez-Alba O, Cianférani S

Anal Chem. 2023 02 15;:

Benefits and Limitations of High-Resolution Cyclic IM-MS for Conformational Characterization of Native Therapeutic Monoclonal Antibodies.

Deslignière E, Ollivier S, Beck A, Ropartz D, Rogniaux H, Cianférani S

Anal Chem. 2023 02 13;:

Timed use of digoxin prevents heart ischemia-reperfusion injury through a REV-ERBα-UPS signaling pathway.

Vinod M, Berthier A, Maréchal X, Gheeraert C, Boutry R, Delhaye S, Annicotte JS, Duez H, Hovasse A, Cianférani S, Montaigne D, Eeckhoute J, Staels B, Lefebvre P

Nat Cardiovasc Res. 2022 11 3;1(11):990-1005

A Combination of Native LC-MS Approaches for the Comprehensive Characterization of the Antibody-Drug Conjugate Trastuzumab Deruxtecan.

Deslignière E, Diemer H, Erb S, Coliat P, Pivot X, Detappe A, Hernandez-Alba O, Cianférani S

Front Biosci (Landmark Ed). 2022 10 26;27(10):290

A novel nuclear receptor subfamily enlightens the origin of heterodimerization.

Beinsteiner B, Markov GV, Bourguet M, McEwen AG, Erb S, Patel AKM, El Khaloufi El Khaddar FZ, Lecroisey C, Holzer G, Essabri K, Hazemann I, Hamiche A, Cianférani S, Moras D, Laudet V, Billas IML

BMC Biol. 2022 10 5;20(1):217

Surface charge influences protein corona, cell uptake and biological effects of carbon dots.

Arezki Y, Delalande F, Schaeffer-Reiss C, Cianférani S, Rapp M, Lebeau L, Pons F, Ronzani C

Nanoscale. 2022 09 28;:

A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity.

Rady T, Turelli L, Nothisen M, Tobaldi E, Erb S, Thoreau F, Hernandez-Alba O, Cianferani S, Daubeuf F, Wagner A, Chaubet G

Bioconjug Chem. 2022 09 15;:

Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis.

Bobowski-Gerard M, Boulet C, Zummo FP, Dubois-Chevalier J, Gheeraert C, Bou Saleh M, Strub JM, Farce A, Ploton M, Guille L, Vandel J, Bongiovanni A, Very N, Woitrain E, Deprince A, Lalloyer F, Bauge E, Ferri L, Ntandja-Wandji LC, Cotte AK, Grangette C, Vallez E, Cianférani S, Raverdy V, Caiazzo R, Gnemmi V, Leteurtre E, Pourcet B, Paumelle R, Ravnskjaer K, Lassailly G, Haas JT, Mathurin P, Pattou F, Dubuquoy L, Staels B, Lefebvre P, Eeckhoute J

Nat Commun. 2022 09 10;13(1):5324

Deciphering cellular and molecular determinants of human DPCD protein in complex with RUVBL1/RUVBL2 AAA-ATPases.

Dos Santos Morais R, Santo PE, Ley M, Schelcher C, Abel Y, Plassart L, Deslignière E, Chagot ME, Quinternet M, Paiva ACF, Hessmann S, Morellet N, M F Sousa P, Vandermoere F, Bertrand E, Charpentier B, Bandeiras TM, Plisson-Chastang C, Verheggen C, Cianférani S, Manival X

J Mol Biol. 2022 07 25;:167760

Large-Scale Conformational Changes of FhaC Provide Insights Into the Two-Partner Secretion Mechanism.

Sicoli G, Konijnenberg A, Guérin J, Hessmann S, Del Nero E, Hernandez-Alba O, Lecher S, Rouaut G, Müggenburg L, Vezin H, Cianférani S, Sobott F, Schneider R, Jacob-Dubuisson F

Front Mol Biosci. 2022 07 22;9:950871

Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.

Sebastiani M, Behrens C, Dörr S, Gerber HD, Benazza R, Hernandez-Alba O, Cianférani S, Klebe G, Heine A, Reuter K

ACS Chem Biol. 2022 07 11;:

A flexible and original architecture of two unrelated zinc fingers underlies the role of the multitask P1 in RYMV spread.

Poignavent V, Hoh F, Terral G, Yang Y, Gillet FX, Kim JH, Allemand F, Lacombe E, Brugidou C, Cianferani S, Déméné H, Vignols F

J Mol Biol. 2022 07 4;:167715

Upconversion in a d-f [RuYb] Supramolecular Assembly.

Knighton RC, Soro LK, Thor W, Strub JM, Cianférani S, Mély Y, Lenertz M, Wong KL, Platas-Iglesias C, Przybilla F, Charbonnière LJ

J Am Chem Soc. 2022 06 30;:

Insights into the atypical autokinase activity of the Pseudomonas aeruginosa GacS histidine kinase and its interaction with RetS.

Fadel F, Bassim V, Francis VI, Porter SL, Botzanowski T, Legrand P, Perez MM, Bourne Y, Cianférani S, Vincent F

Structure. 2022 06 25;:

Repeated Exposure of Macrophages to Synthetic Amorphous Silica Induces Adaptive Proteome Changes and a Moderate Cell Activation.

Torres A, Collin-Faure V, Diemer H, Moriscot C, Fenel D, Gallet B, Cianférani S, Sergent JA, Rabilloud T

Nanomaterials (Basel). 2022 04 22;12(9):

A Confinement-Driven Nucleation Mechanism of Metal Oxide Nanoparticles Obtained via Thermal Decomposition in Organic Media.

Cotin G, Heinrich B, Perton F, Kiefer C, Francius G, Mertz D, Freis B, Pichon B, Strub JM, Cianférani S, Ortiz Peña N, Ihiawakrim D, Portehault D, Ersen O, Khammari A, Picher M, Banhart F, Sanchez C, Begin-Colin S

Small. 2022 Apr 15;:e2200414

Probing the mechanism of the peroxiredoxin decamer interaction with its reductase sulfiredoxin from the single molecule to the solution scale.

Beaussart A, Canonico F, Mazon H, Hidalgo J, Cianférani S, Le Cordier H, Kriznik A, Rahuel-Clermont S

Nanoscale Horiz. 2022 Mar 2;:

Measuring the NQO2: Melatonin Complex by Native Nano-Electrospray Ionization Mass Spectrometry.

Boutin JA, Stojko J, Ferry G, Cianferani S

Methods Mol Biol. 2022 ;2550:323-328

Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes.

Rady T, Mosser M, Nothisen M, Erb S, Dovgan I, Cianférani S, Wagner A, Chaubet G

RSC Adv. 2021 Nov 10;11(58):36777-36780

Proteomic analysis of Rhodospirillum rubrum after carbon monoxide exposure reveals an important effect on metallic cofactor biosynthesis.

Cavazza C, Collin-Faure V, Pérard J, Diemer H, Cianférani S, Rabilloud T, Darrouzet E

J Proteomics. 2021 Sep 30;:104389

High-Resolution IMS-MS to Assign Additional Disulfide Bridge Pairing in Complementarity-Determining Regions of an IgG4 Monoclonal Antibody.

Deslignière E, Botzanowski T, Diemer H, Cooper-Shepherd DA, Wagner-Rousset E, Colas O, Béchade G, Giles K, Hernandez-Alba O, Beck A, Cianférani S

J Am Soc Mass Spectrom. 2021 Aug 26;:

Catestatin in innate immunity and Cateslytin-derived peptides against superbugs.

Scavello F, Mutschler A, Hellé S, Schneider F, Chasserot-Golaz S, Strub JM, Cianferani S, Haikel Y, Metz-Boutigue MH

Sci Rep. 2021 Aug 2;11(1):15615

Iron Stearate Structures: An Original Tool for Nanoparticles Design.

Perton F, Cotin G, Kiefer C, Strub JM, Cianferani S, Greneche JM, Parizel N, Heinrich B, Pichon B, Mertz D, Begin-Colin S

Inorg Chem. 2021 Aug 2;:

A Class of Valuable (Pro-)Activity-Based Protein Profiling Probes: Application to the Redox-Active Antiplasmodial Agent, Plasmodione.

Cichocki BA, Khobragade V, Donzel M, Cotos L, Blandin S, Schaeffer-Reiss C, Cianférani S, Strub JM, Elhabiri M, Davioud-Charvet E

JACS Au. 2021 May 24;1(5):669-689

State-of-the-Art Native Mass Spectrometry and Ion Mobility Methods to Monitor Homogeneous Site-Specific Antibody-Drug Conjugates Synthesis.

Deslignière E, Ehkirch A, Duivelshof BL, Toftevall H, Sjögren J, Guillarme D, D'Atri V, Beck A, Hernandez-Alba O, Cianférani S

Pharmaceuticals (Basel). 2021 May 24;14(6):

Proteo3Dnet: a web server for the integration of structural information with interactomics data.

Postic G, Andreani J, Marcoux J, Reys V, Guerois R, Rey J, Mouton-Barbosa E, Vandenbrouck Y, Cianferani S, Burlet-Schiltz O, Labesse G, Tufféry P

Nucleic Acids Res. 2021 May 8;:

A structural signature motif enlightens the origin and diversification of nuclear receptors.

Beinsteiner B, Markov GV, Erb S, Chebaro Y, McEwen AG, Cianférani S, Laudet V, Moras D, Billas IML

PLoS Genet. 2021 Apr 21;17(4):e1009492

Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia.

Schleiss C, Carapito R, Fornecker LM, Muller L, Paul N, Tahar O, Pichot A, Tavian M, Nicolae A, Miguet L, Mauvieux L, Herbrecht R, Cianferani S, Freund JN, Carapito C, Maumy-Bertrand M, Bahram S, Bertrand F, Vallat L

Leukemia. 2021 Apr 8;:

The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity.

Bragantini B, Charron C, Bourguet M, Paul A, Tiotiu D, Rothé B, Marty H, Terral G, Hessmann S, Decourty L, Chagot ME, Strub JM, Massenet S, Bertrand E, Quinternet M, Saveanu C, Cianférani S, Labialle S, Manival X, Charpentier B

Nat Commun. 2021 03 25;12(1):1859

Combining label-free and label-based accurate quantifications with SWATH-MS: comparison with SRM and PRM for the evaluation of bovine muscle type effects.

Bons J, Husson G, Chion M, Bonnet M, Maumy-Bertrand M, Delalande F, Cianférani S, Bertrand F, Picard B, Carapito C

Proteomics. 2021 Mar 18;:e2000214

Non-specific interactions of antibody-oligonucleotide conjugates with living cells.

Lehot V, Kuhn I, Nothisen M, Erb S, Kolodych S, Cianférani S, Chaubet G, Wagner A

Sci Rep. 2021 Mar 15;11(1):5881

A proteomic view of cellular responses of macrophages to copper when added as ion or as copper-polyacrylate complex.

Dalzon B, Devcic J, Bons J, Torres A, Diemer H, Ravanel S, Collin-Faure V, Cianférani S, Carapito C, Rabilloud T

J Proteomics. 2021 Mar 1;239:104178

Structural studies of RNase M5 reveal two-metal-ion supported two-step dsRNA cleavage for 5S rRNA maturation.

Oerum S, Catala M, Bourguet M, Gilet L, Barraud P, Cianférani S, Condon C, Tisné C

RNA Biol. 2021 Feb 4;:

Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.

Delfosse V, Huet T, Harrus D, Granell M, Bourguet M, Gardia-Parège C, Chiavarina B, Grimaldi M, Le Mével S, Blanc P, Huang D, Gruszczyk J, Demeneix B, Cianférani S, Fini JB, Balaguer P, Bourguet W

Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):

A proteomic-informed view of the changes induced by loss of cellular adherence: The example of mouse macrophages.

Ramirez Rios S, Torres A, Diemer H, Collin-Faure V, Cianférani S, Lafanechère L, Rabilloud T

PLoS One. 2021 ;16(5):e0252450

Hands on Native Mass Spectrometry Analysis of Multi-protein Complexes.

Erb S, Cianférani S, Marcoux J

Methods Mol Biol. 2021 ;2247:173-191

Rab7-harboring vesicles are carriers of the transferrin receptor through the biosynthetic secretory pathway.

Deffieu MS, Cesonyte I, Delalande F, Boncompain G, Dorobantu C, Song E, Lucansky V, Hirschler A, Cianferani S, Perez F, Carapito C, Gaudin R

Sci Adv. 2021 Jan;7(2):

The Importance of Charge in Perturbing the Aromatic Glue Stabilizing the Protein-Protein Interface of Homodimeric tRNA-Guanine Transglycosylase.

Nguyen A, Nguyen D, Phong Nguyen TX, Sebastiani M, Dörr S, Hernandez-Alba O, Debaene F, Cianférani S, Heine A, Klebe G, Reuter K

ACS Chem Biol. 2020 Nov 9;:

Optimized Sample Preparation and Data Processing of Data-Independent Acquisition Methods for the Robust Quantification of Trace-Level Host Cell Protein Impurities in Antibody Drug Products.

Pythoud N, Bons J, Mijola G, Beck A, Cianférani S, Carapito C

J Proteome Res. 2020 Oct 4;:

How Reversible Are the Effects of Fumed Silica on Macrophages? A Proteomics-Informed View.

Torres A, Dalzon B, Collin-Faure V, Diemer H, Fenel D, Schoehn G, Cianférani S, Carrière M, Rabilloud T

. 2020 Sep 29;10(10):

Molecular determinants of MED1 interaction with the DNA bound VDR-RXR heterodimer.

Belorusova AY, Bourguet M, Hessmann S, Chalhoub S, Kieffer B, Cianférani S, Rochel N

Nucleic Acids Res.. 2020 Sep 29;:

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR.

Osz J, McEwen AG, Bourguet M, Przybilla F, Peluso-Iltis C, Poussin-Courmontagne P, Mély Y, Cianférani S, Jeffries CM, Svergun DI, Rochel N

Nucleic Acids Res.. 2020 Sep 25;48(17):9969-9985

Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs.

Oerum S, Dendooven T, Catala M, Gilet L, Dégut C, Trinquier A, Bourguet M, Barraud P, Cianferani S, Luisi BF, Condon C, Tisné C

Mol. Cell. 2020 Sep 23;:

Towards automation of Collision Induced Unfolding experiments through online Size Exclusion Chromatography coupled to native Mass Spectrometry.

Deslignière E, Ehkirch A, Botzanowski T, Beck A, Hernandez-Alba O, Cianférani S

Anal. Chem.. 2020 Sep 4;:

Computational strategies and challenges for using native ion mobility mass spectrometry in biophysics and structural biology.

Allison TM, Barran PE, Cianférani S, Degiacomi MT, Gabelica V, Grandori R, Marklund EG, Menneteau T, Migas LG, Politis A, Sharon M, Sobott F, Thalassinos K, Benesch JLP

Anal. Chem.. 2020 Jul 15;:

Software requirements for the analysis and interpretation of native ion mobility mass spectrometry data.

Allison TM, Barran PE, Benesch JLP, Cianférani S, Degiacomi MT, Gabelica V, Grandori R, Marklund EG, Menneteau T, Migas LG, Politis A, Sharon M, Sobott F, Thalassinos K

Anal. Chem.. 2020 Jul 10;:

Investigating Ugi / Passerini multicomponent reactions for the Site-Selective Conjugation of Native Trastuzumab.

Sornay C, Hessmann S, Erb S, Dovgan I, Ehkirch A, Botzanowski T, Cianférani S, Wagner A, Chaubet G

Chemistry. 2020 Jun 26;:

Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage.

Ciudad S, Puig E, Botzanowski T, Meigooni M, Arango AS, Do J, Mayzel M, Bayoumi M, Chaignepain S, Maglia G, Cianferani S, Orekhov V, Tajkhorshid E, Bardiaux B, Carulla N

Nat Commun. 2020 Jun 15;11(1):3014

Middle level IM-MS and CIU experiments for improved therapeutic immunoglobulin subclass fingerprinting.

Botzanowski T, Hernandez-Alba O, Malissard M, Wagner-Rousset E, Deslignière E, Colas O, Haeuw JF, Beck A, Cianférani S

Anal. Chem.. 2020 May 26;:

Glycan-mediated technology for obtaining homogeneous site-specific conjugated antibody-drug conjugates: synthesis and analytical characterization by using complementary middle-up LC/HRMS analysis.

Duivelshof BL, Deslignière E, Hernandez-Alba O, Ehkirch A, Toftevall H, Sjögren J, Cianférani S, Beck A, Guillarme D, D'Atri V

Anal. Chem.. 2020 May 14;:

On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency.

Dovgan I, Ehkirch A, Lehot V, Kuhn I, Koniev O, Kolodych S, Hentz A, Ripoll M, Ursuegui S, Nothisen M, Cianférani S, Wagner A

Sci Rep. 2020 May 6;10(1):7691

Probing protein interaction networks by combining MS-based proteomics and structural data integration.

Postic G, Marcoux J, Reys V, Andreani J, VandenBrouck Y, Bousquet MP, Mouton-Barbosa E, Cianférani S, Burlet-Schiltz O, Guerois R, Labesse G, Tuffery P

J. Proteome Res.. 2020 Apr 27;:

Ethynylation of Cysteines from Peptides to Proteins in Living Cells.

Tessier R, Nandi RK, Dwyer BG, Abegg D, Sornay C, Ceballos J, Erb S, Cianferani S, Wagner A, Chaubet G, Adibekian A, Waser J

Angew. Chem. Int. Ed. Engl.. 2020 Mar 31;:

Proline: an efficient and user-friendly software suite for large-scale proteomics.

Bouyssié D, Hesse AM, Mouton-Barbosa E, Rompais M, Macron C, Carapito C, de Peredo AG, Couté Y, Dupierris V, Burel A, Menetrey JP, Kalaitzakis A, Poisat J, Romdhani A, Burlet-Schiltz O, Cianférani S, Garin J, Bruley C

Bioinformatics. 2020 Feb 25;:

(Thia)calixarenephosphonic acids as potent inhibitors of the nucleic acid chaperone activity of the HIV-1 nucleocapsid protein with a new binding mode and multi-target antiviral activity.

Humbert N, Kovalenko L, Saladini F, Giannini A, Pires M, Botzanowski T, Cherenok S, Boudier C, Sharma KK, Real E, Zaporozhets OA, Cianférani S, Seguin-Devaux C, Poggialini F, Botta M, Zazzi M, Kalchenko VI, Mori M, Mély Y

ACS Infect Dis. 2020 Feb 11;:

Determination of size variants by CE-SDS for approved therapeutic antibodies: Key implications of subclasses and light chain specificities.

Wagner E, Colas O, Chenu S, Goyon A, Murisier A, Cianferani S, François Y, Fekete S, Guillarme D, D'Atri V, Beck A

J Pharm Biomed Anal. 2020 Feb 10;184:113166

Automated linkage of proteins and payloads producing monodisperse conjugates.

Dovgan I, Hentz A, Koniev O, Ehkirch A, Hessmann S, Ursuegui S, Delacroix S, Riomet M, Taran F, Cianférani S, Kolodych S, Wagner A

Chem Sci. 2020 Jan 2;11(5):1210-1215

Analysis of ADCs by Native Mass Spectrometry.

Hernandez-Alba O, Ehkirch A, Beck A, Cianférani S

Methods Mol. Biol.. 2020 ;2078:197-211

Drug Loading and Distribution of ADCs After Reduction or IdeS Digestion and Reduction.

Wagner-Rousset E, Colas O, François YN, Heinisch S, Guillarme D, Cianférani S, Beck A

Methods Mol. Biol.. 2020 ;2078:187-195

A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry.

Hernandez-Alba O, Houel S, Hessmann S, Erb S, Rabuka D, Huguet R, Josephs J, Beck A, Drake PM, Cianférani S

J. Am. Soc. Mass Spectrom.. 2019 Nov 1;30(11):2419-2429

VHH characterization.Recombinant VHHs: Production, characterization and affinity.

Chabrol E, Stojko J, Nicolas A, Botzanowski T, Fould B, Antoine M, Cianférani S, Ferry G, Boutin JA

Anal. Biochem.. 2019 Oct 29;:113491

Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells.

Ayala-Nunez NV, Follain G, Delalande F, Hirschler A, Partiot E, Hale GL, Bollweg BC, Roels J, Chazal M, Bakoa F, Carocci M, Bourdoulous S, Faklaris O, Zaki SR, Eckly A, Uring-Lambert B, Doussau F, Cianferani S, Carapito C, Jacobs FMJ, Jouvenet N, Goetz JG, Gaudin R

Nat Commun. 2019 Sep 27;10(1):4430

Toxoplasma gondii ROP16 kinase silences the cyclin B1 gene promoter by hijacking host cell UHRF1-dependent epigenetic pathways.

Sabou M, Doderer-Lang C, Leyer C, Konjic A, Kubina S, Lennon S, Rohr O, Viville S, Cianférani S, Candolfi E, Pfaff AW, Brunet J

Cell. Mol. Life Sci.. 2019 Sep 6;:

A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry.

Hernandez-Alba O, Houel S, Hessmann S, Erb S, Rabuka D, Huguet R, Josephs J, Beck A, Drake PM, Cianférani S

J. Am. Soc. Mass Spectrom.. 2019 Aug 19;:

VHH characterization. Comparison of recombinant and the chemically synthesized anti-HER2 VHH.

Hartmann L, Botzanowski T, Galibert M, Jullian M, Chabrol E, Zeder-Lutz G, Kugler V, Stojko J, Strub JM, Ferry G, Frankiewicz L, Puget K, Wagner R, Cianférani S, Boutin JA

Protein Sci.. 2019 Aug 19;:

Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin.

Gervason S, Larkem D, Mansour AB, Botzanowski T, Müller CS, Pecqueur L, Le Pavec G, Delaunay-Moisan A, Brun O, Agramunt J, Grandas A, Fontecave M, Schünemann V, Cianférani S, Sizun C, Tolédano MB, D'Autréaux B

Nat Commun. 2019 Aug 8;10(1):3566

A Proteomic View of Cellular Responses to Anticancer Quinoline-Copper Complexes.

Dalzon B, Bons J, Diemer H, Collin-Faure V, Marie-Desvergne C, Dubosson M, Cianferani S, Carapito C, Rabilloud T

Proteomes. 2019 Jun 24;7(2):

A Combined N-terminomics and Shotgun Proteomics Approach to Investigate the Responses of Human Cells to Rapamycin and Zinc at the Mitochondrial Level.

Bons J, Macron C, Aude-Garcia C, Alvaro Vaca-Jacome S, Rompais M, Cianférani S, Carapito C, Rabilloud T

Mol. Cell Proteomics. 2019 Jun;18(6):1085-1095

A Combined N-terminomics and Shotgun Proteomics Approach to Investigate the Responses of Human Cells to Rapamycin and Zinc at the Mitochondrial Level.

Bons J, Macron C, Aude-Garcia C, Vaca-Jacome SA, Rompais M, Cianférani S, Carapito C, Rabilloud T

Mol Cell Proteomics. 2019 Jun;18(6):1085-1095

A Combined N-terminomics and Shotgun Proteomics Approach to Investigate the Responses of Human Cells to Rapamycin and Zinc at the Mitochondrial Level.

Bons J, Macron C, Aude-Garcia C, Vaca-Jacome SA, Rompais M, Cianférani S, Carapito C, Rabilloud T

Mol Cell Proteomics. 2019 Jun;18(6):1085-1095

Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and future.

Beck A, D'Atri V, Ehkirch A, Fekete S, Hernandez-Alba O, Gahoual R, Leize-Wagner E, François Y, Guillarme D, Cianférani S

Expert Rev Proteomics. 2019 Feb 1;:

Multi-omics dataset to decipher the complexity of drug resistance in diffuse large B-cell lymphoma.

Fornecker LM, Muller L, Bertrand F, Paul N, Pichot A, Herbrecht R, Chenard MP, Mauvieux L, Vallat L, Bahram S, Cianférani S, Carapito R, Carapito C

Sci Rep. 2019 Jan 29;9(1):895

Recurrent activating mutations of PPARγ associated with luminal bladder tumors.

Rochel N, Krucker C, Coutos-Thévenot L, Osz J, Zhang R, Guyon E, Zita W, Vanthong S, Hernandez OA, Bourguet M, Badawy KA, Dufour F, Peluso-Iltis C, Heckler-Beji S, Dejaegere A, Kamoun A, de Reyniès A, Neuzillet Y, Rebouissou S, Béraud C, Lang H, Massfelder T, Allory Y, Cianférani S, Stote RH, Radvanyi F, Bernard-Pierrot I

Nat Commun. 2019 Jan 16;10(1):253

Synthesis and biological evaluation of 2.4 nm thiolate-protected gold nanoparticles conjugated to Cetuximab for targeting glioblastoma cancer cells via the EGFR.

Groysbeck N, Stoessel A, Donzeau M, Cruz da Silva E, Lehmann M, Strub JM, Cianferani S, Dembélé K, Zuber G

Nanotechnology. 2019 Jan 16;:

Tube-Gel: A Fast and Effective Sample Preparation Method for High-Throughput Quantitative Proteomics.

Muller L, Fornecker L, Cianferani S, Carapito C

Methods Mol. Biol.. 2019 ;1959:123-127

Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex.

Berthier A, Vinod M, Porez G, Steenackers A, Alexandre J, Yamakawa N, Gheeraert C, Ploton M, Maréchal X, Dubois-Chevalier J, Hovasse A, Schaeffer-Reiss C, Cianférani S, Rolando C, Bray F, Duez H, Eeckhoute J, Lefebvre T, Staels B, Lefebvre P

Proc. Natl. Acad. Sci. U.S.A.. 2018 Nov 5;:

A novel online four-dimensional SECxSEC-IMxMS methodology for characterization of monoclonal antibody size variants.

Ehkirch A, Goyon A, Hernandez-Alba O, Rouviere F, D'Atri V, Dreyfus C, Haeuw JF, Diemer H, Beck A, Heinisch S, Guillarme D, Cianférani S

Anal. Chem.. 2018 Oct 29;:

The HO-Resistant Fe-S Redox Switch MitoNEET Acts as a pH Sensor To Repair Stress-Damaged Fe-S Protein.

Mons C, Botzanowski T, Nikolaev A, Hellwig P, Cianférani S, Lescop E, Bouton C, Golinelli-Cohen MP

Biochemistry. 2018 Sep 11;:

Stable Isotope-Labelled Morphine to Study in vivo Central and Peripheral Morphine Glucuronidation and Brain Transport in Tolerant Mice.

Weinsanto I, Laux-Biehlmann A, Mouheiche J, Maduna T, Delalande F, Chavant V, Gabel F, Darbon P, Charlet A, Poisbeau P, Lamshöft M, Van Dorsselaer A, Cianferani S, Parat MO, Goumon Y

Br. J. Pharmacol.. 2018 Jul 26;:

The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles.

Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA

Cell Rep. 2018 Jul 24;24(4):973-986.e8

Multi-OMICS analyses unveil as a potential modifier gene in mevalonate kinase deficiency.

Carapito R, Carapito C, Morlon A, Paul N, Vaca Jacome AS, Alsaleh G, Rolli V, Tahar O, Aouadi I, Rompais M, Delalande F, Pichot A, Georgel P, Messer L, Sibilia J, Cianferani S, Van Dorsselaer A, Bahram S

Ann. Rheum. Dis.. 2018 Jul 20;:

Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex.

Henri J, Chagot ME, Bourguet M, Abel Y, Terral G, Maurizy C, Aigueperse C, Georgescauld F, Vandermoere F, Saint-Fort R, Behm-Ansmant I, Charpentier B, Pradet-Balade B, Verheggen C, Bertrand E, Meyer P, Cianférani S, Manival X, Quinternet M

Structure. 2018 Jul 18;:

Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes.

van Tran N, Muller L, Ross RL, Lestini R, Létoquart J, Ulryck N, Limbach PA, de Crécy-Lagard V, Cianférani S, Graille M

Nucleic Acids Res.. 2018 Jul 13;:

The Nuclear Bile Acid Receptor FXR is a PKA- and FOXA2-Sensitive Activator of Fasting Hepatic Gluconeogenesis.

Ploton M, Mazuy C, Gheeraert C, Dubois V, Berthier A, Dubois-Chevalier J, Maréchal X, Bantubungi-Blum K, Diemer H, Cianférani S, Strub JM, Helleboid-Chapman A, Eeckhoute J, Staels B, Lefebvre P

J. Hepatol.. 2018 Jul 4;:

Native Mass Spectrometry, Ion Mobility and Collision Induced Unfolding for Conformational Characterization of IgG4 Monoclonal Antibodies.

Hernandez-Alba O, Wagner-Rousset E, Beck A, Cianférani S

Anal. Chem.. 2018 Jun 29;:

Swapping Interface Contacts in the Homodimeric tRNA-Guanine Transglycosylase: An Option for Functional Regulation.

Ehrmann FR, Kalim J, Pfaffeneder T, Bernet B, Hohn C, Schäfer E, Botzanowski T, Cianférani S, Heine A, Reuter K, Diederich F, Klebe G

Angew. Chem. Int. Ed. Engl.. 2018 Jun 21;:

D-Cateslytin: a new antifungal agent for the treatment of oral Candida albicans associated infections.

Dartevelle P, Ehlinger C, Zaet A, Boehler C, Rabineau M, Westermann B, Strub JM, Cianferani S, Haïkel Y, Metz-Boutigue MH, Marban C

Sci Rep. 2018 Jun 18;8(1):9235

Homodimer architecture of QTRT2, the noncatalytic subunit of the eukaryotic tRNA-guanine transglycosylase.

Behrens C, Biela I, Petiot-Bécard S, Botzanowski T, Cianférani S, Sager CP, Klebe G, Heine A, Reuter K

Biochemistry. 2018 Jun 4;:

Hyphenation of size exclusion chromatography to native ion mobility mass spectrometry for the analytical characterization of therapeutic antibodies and related products.

Ehkirch A, Hernandez-Alba O, Colas O, Beck A, Guillarme D, Cianférani S

J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.. 2018 Jun 1;1086:176-183

Extended investigation of tube-gel sample preparation: a versatile and simple choice for high throughput quantitative proteomics.

Muller L, Fornecker L, Chion M, Van Dorsselaer A, Cianférani S, Rabilloud T, Carapito C

Sci Rep. 2018 May 29;8(1):8260

The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones.

Maurizy C, Quinternet M, Abel Y, Verheggen C, Santo PE, Bourguet M, C F Paiva A, Bragantini B, Chagot ME, Robert MC, Abeza C, Fabre P, Fort P, Vandermoere F, M F Sousa P, Rain JC, Charpentier B, Cianférani S, Bandeiras TM, Pradet-Balade B, Manival X, Bertrand E

Nat Commun. 2018 May 29;9(1):2093

Formation of Mono- and Polynuclear Luminescent Lanthanide Complexes based on the Coordination of Preorganized Phosphonated Pyridines.

Salaam J, Tabti L, Bahamyirou S, Lecointre A, Hernandez Alba O, Jeannin O, Camerel F, Cianférani S, Bentouhami E, Nonat AM, Charbonnière LJ

Inorg Chem. 2018 May 10;:

Reduction-rebridging strategy for the preparation of ADPN-based antibody-drug conjugates.

Koniev O, Dovgan I, Renoux B, Ehkirch A, Eberova J, Cianférani S, Kolodych S, Papot S, Wagner A

Medchemcomm. 2018 May 1;9(5):827-830

Arginine-selective bioconjugation with 4-azidophenyl glyoxal: application to the single and dual functionalisation of native antibodies.

Dovgan I, Erb S, Hessmann S, Ursuegui S, Michel C, Muller C, Chaubet G, Cianférani S, Wagner A

Org. Biomol. Chem.. 2018 Feb 21;16(8):1305-1311

An Online Four-Dimensional HIC×SEC-IM×MS Methodology for Proof-of-Concept Characterization of Antibody Drug Conjugates.

Ehkirch A, D'Atri V, Rouviere F, Hernandez-Alba O, Goyon A, Colas O, Sarrut M, Beck A, Guillarme D, Heinisch S, Cianferani S

Anal. Chem.. 2018 Feb 6;90(3):1578-1586

Peptide deformylases from Vibrio parahaemolyticus phage and bacteria display similar deformylase activity and inhibitor binding clefts.

Grzela R, Nusbaum J, Fieulaine S, Lavecchia F, Desmadril M, Nhiri N, Van Dorsselaer A, Cianferani S, Jacquet E, Meinnel T, Giglione C

Biochim. Biophys. Acta. 2018 02;1866(2):348-355

Structure-Based Identification of HIV-1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV-1 Strains.

Mori M, Kovalenko L, Malancona S, Saladini F, De Forni D, Pires M, Humbert N, Real E, Botzanowski T, Cianférani S, Giannini A, Dasso Lang MC, Cugia G, Poddesu B, Lori F, Zazzi M, Harper S, Summa V, Mely Y, Botta M

ACS Chem. Biol.. 2018 01 19;13(1):253-266

Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities during Bioprocess Development.

Husson G, Delangle A, O'Hara J, Cianferani S, Gervais A, Van Dorsselaer A, Bracewell D, Carapito C

Anal. Chem.. 2018 Jan 16;90(2):1241-1247

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1.

Prudent R, Demoncheaux N, Diemer H, Collin-Faure V, Kapur R, Paublant F, Lafanechère L, Cianférani S, Rabilloud T

PLoS ONE. 2018 ;13(12):e0208979

Morphine Binds Creatine Kinase B and Inhibits Its Activity.

Weinsanto I, Mouheiche J, Laux-Biehlmann A, Delalande F, Marquette A, Chavant V, Gabel F, Cianferani S, Charlet A, Parat MO, Goumon Y

Front Cell Neurosci. 2018 ;12:464

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

Bouguenina H, Salaun D, Mangon A, Muller L, Baudelet E, Camoin L, Tachibana T, Cianférani S, Audebert S, Verdier-Pinard P, Badache A

Proc. Natl. Acad. Sci. U.S.A.. 2017 Dec 12;114(50):E10687-E10696

Adding a new separation dimension to MS and LC-MS: What is the utility of ion mobility spectrometry?

D'Atri V, Causon T, Hernandez-Alba O, Mutabazi A, Veuthey JL, Cianferani S, Guillarme D

J Sep Sci. 2017 Oct;:

Distinct roles of Pcf11 zinc-binding domains in pre-mRNA 3'-end processing.

Guéguéniat J, Dupin AF, Stojko J, Beaurepaire L, Cianférani S, Mackereth CD, Minvielle-Sébastia L, Fribourg S

Nucleic Acids Res.. 2017 Sep;45(17):10115-10131

Epitope characterization of anti-JAM-A antibodies using orthogonal mass spectrometry and surface plasmon resonance approaches.

Terral G, Champion T, Debaene F, Colas O, Bourguet M, Wagner-Rousset E, Corvaia N, Beck A, Cianferani S

MAbs. 2017 Sep;:0

Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates.

Kolodych S, Michel C, Delacroix S, Koniev O, Ehkirch A, Eberova J, Cianférani S, Renoux B, Krezel W, Poinot P, Muller CD, Papot S, Wagner A

Eur J Med Chem. 2017 Aug;:

The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.

Radu L, Schoenwetter E, Braun C, Marcoux J, Koelmel W, Schmitt DR, Kuper J, Cianférani S, Egly JM, Poterszman A, Kisker C

Nucleic Acids Res.. 2017 Aug;:

Differential proteomics highlights macrophage-specific responses to amorphous silica nanoparticles.

Dalzon B, Aude-Garcia C, Collin-Faure V, Diemer H, Béal D, Dussert F, Fenel D, Schoehn G, Cianférani S, Carrière M, Rabilloud T

Nanoscale. 2017 Jul;:

Development of a fast workflow to screen the charge variants of therapeutic antibodies.

Wagner-Rousset E, Fekete S, Morel-Chevillet L, Colas O, Corvaïa N, Cianférani S, Guillarme D, Beck A

J Chromatogr A. 2017 May;1498:147-154

Acyl Fluorides: Fast, Efficient, and Versatile Lysine-Based Protein Conjugation via Plug-and-Play Strategy.

Dovgan I, Ursuegui S, Erb S, Michel C, Kolodych S, Cianférani S, Wagner A

Bioconjug. Chem.. 2017 Apr;:

Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates.

Botzanowski T, Erb S, Hernandez-Alba O, Ehkirch A, Colas O, Wagner-Rousset E, Rabuka D, Beck A, Drake PM, Cianferani S

MAbs. 2017 Apr;:0

Generic Hybrid Ligand Binding Assay Liquid Chromatography High-Resolution Mass Spectrometry-Based Workflow for Multiplexed Human Immunoglobulin G1 Quantification at the Intact Protein Level: Application to Preclinical Pharmacokinetic Studies.

Lanshoeft C, Cianférani S, Heudi O

Anal. Chem.. 2017 Feb;89(4):2628-2635

A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin.

Licona C, Spaety ME, Capuozzo A, Ali M, Santamaria R, Armant O, Delalande F, Van Dorsselaer A, Cianferani S, Spencer J, Pfeffer M, Mellitzer G, Gaiddon C

Oncotarget. 2017 Jan;8(2):2568-2584

Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor.

Mohideen-Abdul K, Tazibt K, Bourguet M, Hazemann I, Lebars I, Takacs M, Cianférani S, Klaholz BP, Moras D, Billas IML

Front Endocrinol (Lausanne). 2017 ;8:140

Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.

Ehrmann FR, Stojko J, Metz A, Debaene F, Barandun LJ, Heine A, Diederich F, Cianférani S, Reuter K, Klebe G

PLoS ONE. 2017 ;12(4):e0175723

Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.

Cura V, Marechal N, Troffer-Charlier N, Strub JM, van Haren MJ, Martin NI, Cianférani S, Bonnefond L, Cavarelli J

FEBS J.. 2017 Jan;284(1):77-96

Activation mode of the eukaryotic m2G10 tRNA methyltransferase Trm11 by its partner protein Trm112.

Bourgeois G, Marcoux J, Saliou JM, Cianférani S, Graille M

Nucleic Acids Res.. 2016 Dec;:

Benchmarking sample preparation/digestion protocols reveals tube-gel being a fast and repeatable method for quantitative proteomics.

Muller L, Fornecker L, Van Dorsselaer A, Cianférani S, Carapito C

Proteomics. 2016 Dec;16(23):2953-2961

Step by Step Assembly of Polynuclear Lanthanide Complexes with a Phosphonated Bipyridine Ligand.

Souri N, Tian P, Lecointre A, Lemaire Z, Chafaa S, Strub JM, Cianférani S, Elhabiri M, Platas-Iglesias C, Charbonnière LJ

Inorg Chem. 2016 Dec;55(24):12962-12974

VISLISI trial, a prospective clinical study allowing identification of a new metalloprotease and putative virulence factor from Staphylococcus lugdunensis.

Argemi X, Prévost G, Riegel P, Keller D, Meyer N, Baldeyrou M, Douiri N, Lefebvre N, Meghit K, Ronde Oustau C, Christmann D, Cianférani S, Strub JM, Hansmann Y

Clin. Microbiol. Infect.. 2016 Dec;:

Culture medium associated changes in the core proteome of macrophages and in their responses to copper oxide nanoparticles.

Dalzon B, Diemer H, Collin-Faure V, Cianférani S, Rabilloud T, Aude-Garcia C

Proteomics. 2016 Nov;16(22):2864-2877

Looking for Missing Proteins in the Proteome of Human Spermatozoa: An Update.

Vandenbrouck Y, Lane L, Carapito C, Duek P, Rondel K, Bruley C, Macron C, Gonzalez de Peredo A, Couté Y, Chaoui K, Com E, Gateau A, Hesse AM, Marcellin M, Méar L, Mouton-Barbosa E, Robin T, Burlet-Schiltz O, Cianferani S, Ferro M, Fréour T, Lindskog C, Garin J, Pineau C

J. Proteome Res.. 2016 Nov;15(11):3998-4019

Maltaricin CPN, a new class IIa bacteriocin produced by Carnobacterium maltaromaticum CPN isolated from mould-ripened cheese.

Hammi I, Delalande F, Belkhou R, Marchioni E, Cianferani S, Ennahar S

J. Appl. Microbiol.. 2016 Nov;121(5):1268-1274

The flexibility of a generic LC-MS/MS method for the quantitative analysis of therapeutic proteins based on human immunoglobulin G and related constructs in animal studies.

Lanshoeft C, Wolf T, Walles M, Barteau S, Picard F, Kretz O, Cianférani S, Heudi O

J Pharm Biomed Anal. 2016 Nov;131:214-222

Insights from native mass spectrometry and ion mobility-mass spectrometry for antibody and antibody-based product characterization.

Terral G, Beck A, Cianférani S

J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.. 2016 Oct;1032:79-90

MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.

Frottin F, Bienvenut WV, Bignon J, Jacquet E, Vaca Jacome AS, Van Dorsselaer A, Cianferani S, Carapito C, Meinnel T, Giglione C

Oncotarget. 2016 Sep;7(39):63306-63323

Palladium-Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine-Containing Molecules at Room Temperature.

Al-Shuaeeb RA, Kolodych S, Koniev O, Delacroix S, Erb S, Nicolaÿ S, Cintrat JC, Brion JD, Cianférani S, Alami M, Wagner A, Messaoudi S

Chemistry. 2016 Aug;22(32):11365-70

Functional and Structural Insights of the Zinc-Finger HIT protein family members Involved in Box C/D snoRNP Biogenesis.

Bragantini B, Tiotiu D, Rothé B, Saliou JM, Marty H, Cianférani S, Charpentier B, Quinternet M, Manival X

J. Mol. Biol.. 2016 Jun;428(11):2488-506

Quantitative analysis of hIgG1 in monkey serum by LC-MS/MS using mass spectrometric immunoassay.

Lanshoeft C, Heudi O, Cianférani S, Warren AP, Picard F, Kretz O

Bioanalysis. 2016 May;8(10):1035-49

SMART Digest™ compared with pellet digestion for analysis of human immunoglobulin G1 in rat serum by liquid chromatography tandem mass spectrometry.

Lanshoeft C, Heudi O, Cianférani S

Anal. Biochem.. 2016 May;501:23-5

Greatwall dephosphorylation and inactivation upon mitotic exit is triggered by PP1.

Ma S, Vigneron S, Robert P, Strub JM, Cianferani S, Castro A, Lorca T

J. Cell. Sci.. 2016 Apr;129(7):1329-39

Spiked proteomic standard dataset for testing label-free quantitative software and statistical methods.

Ramus C, Hovasse A, Marcellin M, Hesse AM, Mouton-Barbosa E, Bouyssié D, Vaca S, Carapito C, Chaoui K, Bruley C, Garin J, Cianférani S, Ferro M, Dorssaeler AV, Burlet-Schiltz O, Schaeffer C, Couté Y, Gonzalez de Peredo A

Data Brief. 2016 Mar;6:286-94

A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages.

Aude-Garcia C, Dalzon B, Ravanat JL, Collin-Faure V, Diemer H, Strub JM, Cianferani S, Van Dorsselaer A, Carrière M, Rabilloud T

J Proteomics. 2016 Feb;134:174-85

Molecular responses of alveolar epithelial A549 cells to chronic exposure to titanium dioxide nanoparticles: A proteomic view.

Armand L, Biola-Clier M, Bobyk L, Collin-Faure V, Diemer H, Strub JM, Cianferani S, Van Dorsselaer A, Herlin-Boime N, Rabilloud T, Carriere M

J Proteomics. 2016 Feb;134:163-73

Probing Supramolecular Interactions between a Crown Ether Appended Zinc Phthalocyanine and an Ammonium Group Appended to a C60 Derivative.

Lederer M, Hahn U, Strub JM, Cianférani S, Van Dorsselaer A, Nierengarten JF, Torres T, Guldi DM

Chemistry. 2016 Feb;22(6):2051-2059

The use of generic surrogate peptides for the quantitative analysis of human immunoglobulin G1 in pre-clinical species with high-resolution mass spectrometry.

Lanshoeft C, Wolf T, Heudi O, Cianférani S, Barteau S, Walles M, Picard F, Kretz O

Anal Bioanal Chem. 2016 Feb;408(6):1687-99

Benchmarking quantitative label-free LC-MS data processing workflows using a complex spiked proteomic standard dataset.

Ramus C, Hovasse A, Marcellin M, Hesse AM, Mouton-Barbosa E, Bouyssié D, Vaca S, Carapito C, Chaoui K, Bruley C, Garin J, Cianférani S, Ferro M, Van Dorssaeler A, Burlet-Schiltz O, Schaeffer C, Couté Y, Gonzalez de Peredo A

J Proteomics. 2016 Jan;132:51-62

Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates.

Beck A, Terral G, Debaene F, Wagner-Rousset E, Marcoux J, Janin-Bussat MC, Colas O, Van Dorsselaer A, Cianférani S

Expert Rev Proteomics. 2016 ;13(2):157-83

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.

Thébault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honoré J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianférani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J

Sci Rep. 2016 Jan;6:19725

Ion mobility coupled to native mass spectrometry as a relevant tool to investigate extremely small ligand-induced conformational changes.

Stojko J, Fieulaine S, Petiot-Becard S, Van Dorsselaer A, Meinnel T, Giglione C, Cianferani S

Analyst. 2015 Nov 7;140(21):7234-45

MAPN: First-in-Class Reagent for Kinetically Resolved Thiol-to-Thiol Conjugation.

Koniev O, Kolodych S, Baatarkhuu Z, Stojko J, Eberova J, Bonnefoy JY, Cianferani S, Van Dorsselaer A, Wagner A

Bioconjug Chem. 2015 Sep 3.

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis.

Marcoux J, Mangione PP, Porcari R, Degiacomi MT, Verona G, Taylor GW, Giorgetti S, Raimondi S, Sanglier-Cianferani S, Benesch JL, Cecconi C, Naqvi MM, Gillmore JD, Hawkins PN, Stoppini M, Robinson CV, Pepys MB, Bellotti V

EMBO Mol Med. 2015 Aug 18. pii: e201505357

Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly.

Quinternet M, Rothe B, Barbier M, Bobo C, Saliou JM, Jacquemin C, Back R, Chagot ME, Cianferani S, Meyer P, Branlant C, Charpentier B, Manival X

J Mol Biol. 2015 Aug 28;427(17):2816-39

What Glues a Homodimer Together: Systematic Analysis of the Stabilizing Effect of an Aromatic Hot Spot in the Protein-Protein Interface of the tRNA-Modifying Enzyme Tgt.

Jakobi S, Nguyen PT, Debaene F, Cianférani S, Reuter K, Klebe G

ACS Chem. Biol.. 2015 Aug;10(8):1897-907

Computational and mass spectrometry-based workflow for the discovery and validation of missing human proteins: application to chromosomes 2 and 14.

Carapito C, Lane L, Benama M, Opsomer A, Mouton-Barbosa E, Garrigues L, Gonzalez de Peredo A, Burel A, Bruley C, Gateau A, Bouyssie D, Jaquinod M, Cianferani S, Burlet-Schiltz O, Van Dorsselaer A, Garin J, Vandenbrouck Y

J Proteome Res. 2015 Jul 1.

Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.

Bonnefond L, Stojko J, Mailliot J, Troffer-Charlier N, Cura V, Wurtz JM, Cianferani S, Cavarelli J

J Struct Biol. 2015 Jun 18. pii: S1047-8477(15)30021-6

Towards integrative structural mass spectrometry: Benefits from hybrid approaches.

Marcoux J, Cianferani S

Methods. 2015 May 29. pii: S1046-2023(15)00230-3

Characterization of the N-terminal heterogeneities of monoclonal antibodies using in-gel charge derivatization of alpha-amines and LC-MS/MS.

Ayoub D, Bertaccini D, Diemer H, Wagner-Rousset E, Colas O, Cianferani S, Van Dorsselaer A, Beck A, Schaeffer-Reiss C

Anal Chem. 2015 Apr 7;87(7):3784-90

Intermolecular recognition of the non-coding RNA 7SK and HEXIM protein in perspective.

Martinez-Zapien D, Saliou JM, Xiao H, Atmanene C, Proux F, Cianferani S, Dock-Bregeon AC

Biochimie. 2015 Apr 8. pii: S0300-9084(15)00089-9

Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist.

Simonneau C, Bérénice Leclercq,Mougel A, Adriaenssens E, Paquet C, Raibaut L, Ollivier N, Drobecq H, Marcoux J, Cianférani S, Tulasne D, de Jonge H, Melnyk O, Vicogne J

Chem Sci. 2015 Mar;6(3):2110-2121

CBTF: new amine-to-thiol coupling reagent for preparation of antibody conjugates with increased plasma stability.

Kolodych S, Koniev O, Baatarkhuu Z, Bonnefoy JY, Debaene F, Cianferani S, Van Dorsselaer A, Wagner A

Bioconjug Chem. 2015 Feb 18;26(2):197-200

Combining native MS approaches to decipher archaeal box H/ACA ribonucleoprotein particle structure and activity.

Saliou JM, Manival X, Tillault AS, Atmanene C, Bobo C, Branlant C, Van Dorsselaer A, Charpentier B, Cianferani S

Proteomics. 2015 Feb 27

Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies.

Beck A, Debaene F, Diemer H, Wagner-Rousset E, Colas O, Van Dorsselaer A, Cianferani S

J Mass Spectrom. 2015 Feb;50(2):285-97

Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies.

Beck A, Debaene F, Diemer H, Wagner-Rousset E, Colas O, Van Dorsselaer A, Cianferani S

J Mass Spectrom. 2015 Feb;50(2):ii

Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate.

Marcoux J, Champion T, Colas O, Wagner-Rousset E, Corvaia N, Van Dorsselaer A, Beck A, Cianferani S

Protein Sci. 2015 Feb 18

Innovative native MS methodologies for antibody drug conjugate characterization: High resolution native MS and IM-MS for average DAR and DAR distribution assessment.

Debaene F, Boeuf A, Wagner-Rousset E, Colas O, Ayoub D, Corvaia N, Van Dorsselaer A, Beck A, Cianferani S

Anal Chem. 2014 Nov 4;86(21):10674-83

Hot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzyme.

Jakobi S, Nguyen TX, Debaene F, Metz A, Sanglier-Cianferani S, Reuter K, Klebe G

Proteins. 2014 Oct;82(10):2713-32

In vivo tmRNA protection by SmpB and pre-ribosome binding conformation in solution.

Ranaei-Siadat E, Merigoux C, Seijo B, Ponchon L, Saliou JM, Bernauer J, Sanglier-Cianferani S, Dardel F, Vachette P, Nonin-Lecomte S

RNA. 2014 Oct;20(10):1607-20

Functional and structural characterization of 2-amino-4-phenylthiazole inhibitors of the HIV-1 nucleocapsid protein with antiviral activity.

Mori M, Nucci A, Lang MC, Humbert N, Boudier C, Debaene F, Sanglier-Cianferani S, Catala M, Schult-Dietrich P, Dietrich U, Tisne C, Mely Y, Botta M

ACS Chem Biol. 2014 Sep 19;9(9):1950-5

Comparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets.

Feve M, Saliou JM, Zeniou M, Lennon S, Carapito C, Dong J, Van Dorsselaer A, Junier MP, Chneiweiss H, Cianferani S, Haiech J, Kilhoffer MC

PLoS One. 2014 Mar 24;9(3):e91519

Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction.

Rothe B, Saliou JM, Quinternet M, Back R, Tiotiu D, Jacquemin C, Loegler C, Schlotter F, Pena V, Eckert K, Morera S, Dorsselaer AV, Branlant C, Massenet S, Sanglier-Cianferani S, Manival X, Charpentier B

Nucleic Acids Res. 2014;42(16):10731-47

Time resolved native ion-mobility mass spectrometry to monitor dynamics of IgG4 Fab arm exchange and "bispecific" monoclonal antibody formation.

Debaene F, Wagner-Rousset E, Colas O, Ayoub D, Corvaia N, Van Dorsselaer A, Beck A, Cianferani S

Anal Chem. 2013 Oct 15;85(20):9785-92

Cell-surface expression of the TLR homolog CD180 in circulating cells from splenic and nodal marginal zone lymphomas.

Miguet L, Lennon S, Baseggio L, Traverse-Glehen A, Berger F, Perrusson N, Chenard MP, Galoisy AC, Eischen A, Mayeur-Rousse C, Maar A, Fornecker L, Herbrecht R, Felman P, Van Dorsselaer A, Carapito C, Cianférani S, Mauvieux L

Leukemia. 2013 Aug;27(8):1748-50

Analytical characterization of biosimilar antibodies and Fc-fusion proteins.

Beck A, Diemer H, Ayoub D, Debaene F, Wagner-Rousset E, Carapito C, Van Dorsselaer A, Sanglier-Cianferani S

Trac-trends Anal Chem. 2013 Jul-aug;48:81-95.

The RYMV-encoded viral suppressor of RNA silencing P1 is a zinc-binding protein with redox-dependent flexibility.

Gillet FX, Cattoni DI, Petiot-Becard S, Delalande F, Poignavent V, Brizard JP, Bessin Y, Dorsselaer AV, Declerck N, Sanglier-Cianferani S, Brugidou C, Vignols F

J Mol Biol. 2013 Jul 24;425(14):2423-35

Launching Spiking Ligands into a Protein Protein Interface: A Promising Strategy To Destabilize and Break Interface Formation in a tRNA Modifying Enzyme.

Immekus F, Barandun LJ, Betz M, Debaene F, Petiot S, Sanglier-Cianferani S, Reuter K, Diederich F, Klebe G

Acs Chem Biol. 2013 Jun;8(6):1163-78.

Noncovalent mass spectrometry for the characterization of antibody/antigen complexes.

Atmanene C, Wagner-Rousset E, Corvaia N, Van Dorsselaer A, Beck A, Sanglier-Cianferani S

Methods Mol Biol. 2013;988:243-68

Crystal packing modifies ligand binding affinity: the case of aldose reductase.

Cousido-Siah A, Petrova T, Hazemann I, Mitschler A, Ruiz FX, Howard E, Ginell S, Atmanene C, Van Dorsselaer A, Sanglier-Cianferani S, Joachimiak A, Podjarny A

Proteins. 2012 Nov;80(11):2552-61

Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein.

Mori M, Schult-Dietrich P, Szafarowicz B, Humbert N, Debaene F, Sanglier-Cianferani S, Dietrich U, Mely Y, Botta M

Virus Res. 2012 Nov;169(2):377-87

Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger.

Cousido-Siah A, Ayoub D, Berberian G, Bollo M, Van Dorsselaer A, Debaene F, DiPolo R, Petrova T, Schulze-Briese C, Olieric V, Esteves A, Mitschler A, Sanglier-Cianferani S, Beauge L, Podjarny A

Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1098-107

A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions.

Vercruysse T, Basta B, Dehaen W, Humbert N, Balzarini J, Debaene F, Sanglier-Cianferani S, Pannecouque C, Mely Y, Daelemans D

Retrovirology. 2012 Nov 12;9:95

Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma.

Herquel B, Ouararhni K, Khetchoumian K, Ignat M, Teletin M, Mark M, Bechade G, Van Dorsselaer A, Sanglier-Cianferani S, Hamiche A, Cammas F, Davidson I, Losson R

Proc Natl Acad Sci U S A. 2011 May 17;108(20):8212-7

Identification of protein partners of the human immunodeficiency virus 1 tat/rev exon 3 leads to the discovery of a new HIV-1 splicing regulator, protein hnRNP K.

Marchand V, Santerre M, Aigueperse C, Fouillen L, Saliou JM, Van Dorsselaer A, Sanglier-Cianferani S, Branlant C, Motorin Y

RNA Biol. 2011 Mar-Apr;8(2):325-42

Monitoring the dynamics of monomer exchange using electrospray mass spectrometry: the case of the dimeric glucosamine-6-phosphate synthase.

Chevreux G, Atmanene C, Lopez P, Ouazzani J, Van Dorsselaer A, Badet B, Badet-Denisot MA, Sanglier-Cianferani S

J Am Soc Mass Spectrom. 2011 Mar;22(3):431-9

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.

Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2783-8

Analysis of recombinant phosphoprotein complexes with complementary mass spectrometry approaches.

Fouillen L, Abdulrahman W, Moras D, Dorsselaer AV, Poterszman A, Sanglier-Cianferani S

Anal Biochem. 2010 Dec 1;407(1):34-43

Nondenaturing chemical proteomics for protein complex isolation and identification.

Budin G, Moune-Dimala M, Leriche G, Saliou JM, Papillon J, Sanglier-Cianferani S, Van Dorsselaer A, Lamour V, Brino L, Wagner A

Chembiochem. 2010 Nov 22;11(17):2359-61.

The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity.

Eckert K, Saliou JM, Monlezun L, Vigouroux A, Atmane N, Caillat C, Quevillon-Cheruel S, Madiona K, Nicaise M, Lazereg S, Van Dorsselaer A, Sanglier-Cianferani S, Meyer P, Morera S

J Biol Chem. 2010 Oct 8;285(41):31304-12

Physical basis of the inducer-dependent cooperativity of the Central glycolytic genes Repressor/DNA complex.

Chaix D, Ferguson ML, Atmanene C, Van Dorsselaer A, Sanglier-Cianferani S, Royer CA, Declerck N

Nucleic Acids Res. 2010 Sep 1;38(17):5944-57

Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter.

Zimmermann M, Atmanene C, Xu Q, Fouillen L, Van Dorsselaer A, Bonnet D, Marsol C, Hibert M, Sanglier-Cianferani S, Pigault C, McNamara LK, Watterson DM, Haiech J, Kilhoffer MC

PLoS One. 2010 Nov 30;5(11):e14120.

An integrative approach combining noncovalent mass spectrometry, enzyme kinetics and X-ray crystallography to decipher Tgt protein-protein and protein-RNA interaction.

Ritschel T, Atmanene C, Reuter K, Van Dorsselaer A, Sanglier-Cianferani S, Klebe G

J Mol Biol. 2009 Nov 6;393(4):833-47

Extending Mass Spectrometry Contribution to Therapeutic Monoclonal Antibody Lead Optimization: Characterization of Immune Complexes Using Noncovalent ESI-MS

Atmanene C, Wagner-Rousset E, Malissard M, Chol B, Robert A, Corvaia N, Van Dorsselaer A, Beck A, Sanglier-Cianferani S

Anal Chem. 2009 Aug 1;81(15):6364-73.

Characterization of human and bovine phosphatidylethanolamine-binding protein (PEBP/RKIP) interactions with morphine and morphine-glucuronides determined by noncovalent mass spectrometry.

Atmanene C, Laux A, Glattard E, Muller A, Schoentgen F, Metz-Boutigue MH, Aunis D, Van Dorsselaer A, Stefano GB, Sanglier-Cianferani S, Goumon Y

Med Sci Monit. 2009 Jul;15(7):BR178-87.

Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid protein.

Shvadchak V, Sanglier S, Rocle S, Villa P, Haiech J, Hibert M, Van Dorsselaer A, Mely Y, de Rocquigny H

Biochimie. 2009 Jul;91(7):916-23

Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis.

Miguet L, Bechade G, Fornecker L, Zink E, Felden C, Gervais C, Herbrecht R, van Dorsselaer A, Mauvieux L, Sanglier-Cianferani S

J Proteome Res. 2009 Jul;8(7):3346-54.

Detection and structural features of the betaB2-B3-crystallin heterodimer by radical probe mass spectrometry (RP-MS).

Diemer H, Atmanene C, Sanglier S, Morrissey B, Van Dorsselaer A, Downard KM

J Mass Spectrom. 2009 May;44(5):803-12.

Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists.

Germain P, Gaudon C, Pogenberg V, Sanglier S, Van Dorsselaer A, Royer CA, Lazar MA, Bourguet W, Gronemeyer H

Chem Biol. 2009 May 29;16(5):479-89.

Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus.

Tocchini-Valentini GD, Rochel N, Escriva H, Germain P, Peluso-Iltis C, Paris M, Sanglier-Cianferani S, Van Dorsselaer A, Moras D, Laudet V

J Biol Chem. 2009 Jan 16;284(3):1938-48

An optimized MALDI mass spectrometry method for improved detection of lysine/arginine/histidine free peptides.

Argentini M, Strub JM, Carapito C, Sanglier S, Van-Dorsselaer A

J Proteome Res. 2008 Nov;7(11):5062-9

The histone subcode: poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 control cell differentiation by regulating the transcriptional intermediary factor TIF1beta and the heterochromatin protein HP1alpha.

Quenet D, Gasser V, Fouillen L, Cammas F, Sanglier-Cianferani S, Losson R, Dantzer F

FASEB J. 2008 Nov;22(11):3853-65

Evidence for the formation of a covalent thiosulfinate intermediate with peroxiredoxin in the catalytic mechanism of sulfiredoxin.

Roussel X, Bechade G, Kriznik A, Van Dorsselaer A, Sanglier-Cianferani S, Branlant G, Rahuel-Clermont S

J Biol Chem. 2008 Aug 15;283(33):22371-82

Modulation of E-cadherin monomer folding by cooperative binding of calcium ions.

Courjean O, Chevreux G, Perret E, Morel A, Sanglier S, Potier N, Engel J, van Dorsselaer A, Feracci H

Biochemistry. 2008 Feb 26;47(8):2339-49

Nondenaturing mass spectrometry to study noncovalent protein/protein and protein/ligand complexes: technical aspects and application to the determination of binding stoichiometries.

Sanglier S, Atmanene C, Chevreux G, Dorsselaer AV

Methods Mol Biol. 2008;484:217-43.

Endogenous plasma Peptide detection and identification in the rat by a combination of fractionation methods and mass spectrometry.

Bertile F, Robert F, Delval-Dubois V, Sanglier S, Schaeffer C, Van Dorsselaer A

Biomark Insights. 2007 Oct 9;2:385-401.

Unfolding of rabbit muscle creatine kinase induced by acid. A study using electrospray ionization mass spectrometry, isothermal titration calorimetry, and fluorescence spectroscopy.

Liang Y, Du F, Sanglier S, Zhou BR, Xia Y, Van Dorsselaer A, Maechling C, Kilhoffer MC, Haiech J

J Biol Chem. 2003 Aug 8;278(32):30098-105

Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3.

Greschik H, Wurtz JM, Sanglier S, Bourguet W, van Dorsselaer A, Moras D, Renaud JP

Mol Cell. 2002 Feb;9(2):303-13.

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