Dr SPENLÉ Caroline

Fiche personne

Coordonnées

UMR7242 Biotechnologie et Signalisation Cellulaire - ESBS
300 bd Sébastien Brant
CS 10413
67412 ILLKIRCH Cedex

03 68 85 71 54

Territoire

Alsace

Statut

Enseignant-Chercheur

Affiliation

Ecole Supérieure de Biotechnologie de Strasbourg / Biotechnologie et signalisation cellulaire UMR 7242 (ESBS-BSC)

Université de Strasbourg (Unistra)

Équipes/plateformes

UMR 7242 - Equipe "Peptides thérapeutiques"

Publications

Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity.

Li C, Kaur A, Pavlidaki A, Spenlé C, Rajnpreht I, Donnadieu E, Salomé N, Molitor A, Carapito R, Wack F, Erne W, Lefebvre O, Averous G, Mitrentsi I, Loustau T, Orend G

Proc Natl Acad Sci U S A. 2024 10 15;121(42):e2404485121

Complementary strategies to be used in conjunction with animal models for multiple sclerosis drug discovery: adapting preclinical validation of drug candidates to the need of remyelinating strategies.

Charmarke-Askar I, Spenlé C, Bagnard D

Expert Opin Drug Discov. 2024 07 22;:1-10

Fluorinated apelin-13 mediates neuroprotective effects in multiple sclerosis models.

Birmpili D, Charmarké-Askar I, Spenlé C, Riché S, Pham-Van LD, Kuntzel T, Xhurxhi T, Riou A, Bonnet D, Bagnard D

Neurobiol Dis. 2024 06 4;198:106552

Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo.

Toussaint K, Appert-Collin A, Vanalderwiert L, Bour C, Terryn C, Spenlé C, Van Der Heyden M, Roumieux M, Maurice P, Romier-Crouzet B, Sartelet H, Duca L, Blaise S, Bennasroune A

J Biol Chem. 2024 04 23;:107316

Implication of the Transmembrane Domain in the Interleukin 10 Receptor Platform Oligomerisation.

Kuntzel T, Spenlé C, Pham-Van LD, Birmpili D, Riou A, Loeuillet A, Charmarke-Askar I, Bagnard D

Cells. 2023 05 10;12(10):

Toward a Combination of Biomarkers for Molecular Characterization of Multiple Sclerosis.

Birmpili D, Charmarke Askar I, Pham-Van LD, Kuntzel T, Spenlé C, Riou A, Bagnard D

Int J Mol Sci. 2022 11 13;23(22):

Monitoring subcutaneous tumors using Mueller polarimetry: study on two types of tumors.

Varin B, Rehbinder J, Dellinger J, Heinrich C, Torzynski M, Spenlé C, Bagnard D, Zallat J

Biomed Opt Express. 2021 Oct 1;12(10):6055-6065

Impact of Tenascin-C on Radiotherapy in a Novel Syngeneic Oral Squamous Cell Carcinoma Model With Spontaneous Dissemination to the Lymph Nodes.

Spenlé C, Loustau T, Burckel H, Riegel G, Abou Faycal C, Li C, Yilmaz A, Petti L, Steinbach F, Ahowesso C, Jost C, Paul N, Carapito R, Noël G, Anjuère F, Salomé N, Orend G

Front Immunol. 2021 ;12:636108

Tenascin-C orchestrates an immune suppressive tumor microenvironment in oral squamous cell carcinoma.

Spenlé C, Loustau T, Murdamoothoo D, Erne W, Beghelli-de la Forest Divonne S, Veber R, Petti L, Bourdely P, Mörgelin M, Brauchle EM, Crémel G, Randrianarisoa V, Camara A, Rekima S, Schaub S, Nouhen K, Imhof T, Hansen U, Paul N, Carapito R, Pythoud N, Hirschler A, Carapito C, Dumortier H, Mueller CG, Koch M, Schenke-Layland K, Kon S, Sudaka A, Anjuere F, Van Obberghen-Schilling E, Orend G

Cancer Immunol Res. 2020 Jul 14;:

Functionalized Coat Protein Monomers and Oligomers as Nanocarriers for Anti-Cancer Peptides.

Gamper C, Spenlé C, Boscá S, van der Heyden M, Erhardt M, Orend G, Bagnard D, Heinlein M

Cancers (Basel). 2019 Oct 22;11(10):

Disruption of Sema3A/Plexin-A1 inhibitory signalling in oligodendrocytes as a therapeutic strategy to promote remyelination.

Binamé F, Pham-Van LD, Spenlé C, Jolivel V, Birmpili D, Meyer LA, Jacob L, Meyer L, Mensah-Nyagan AG, Po C, Van der Heyden M, Roussel G, Bagnard D

EMBO Mol Med. 2019 Sep 30;:e10378

Tenascin-C increases lung metastasis by impacting blood vessel invasions.

Sun Z, Velázquez-Quesada I, Murdamoothoo D, Ahowesso C, Yilmaz A, Spenlé C, Averous G, Erne W, Oberndorfer F, Oszwald A, Kain R, Bourdon C, Mangin P, Deligne C, Midwood K, Abou-Faycal C, Lefebvre O, Klein A, van der Heyden M, Chenard MP, Christofori G, Mathelin C, Loustau T, Hussenet T, Orend G

Matrix Biol.. 2019 Jul 6;:

Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma.

Mammadova-Bach E, Rupp T, Spenlé C, Jivkov I, Shankaranarayanan P, Klein A, Pisarsky L, Méchine-Neuville A, Cremel G, Kedinger M, De Wever O, Ambartsumian N, Robine S, Pencreach E, Guenot D, Simon-Assmann P, Goetz JG, Orend G, Lefebvre O

Biol. Cell. 2018 Jun 15;:

Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack.

Lee KZ, Lestradet M, Socha C, Schirmeier S, Schmitz A, Spenlé C, Lefebvre O, Keime C, Yamba WM, Bou Aoun R, Liegeois S, Schwab Y, Simon-Assmann P, Dalle F, Ferrandon D

Cell Host Microbe. 2016 Dec;20(6):716-730

Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide.

Jacob L, Sawma P, Garnier N, Meyer LA, Fritz J, Hussenet T, Spenlé C, Goetz J, Vermot J, Fernandez A, Baumlin N, Aci-Sèche S, Orend G, Roussel G, Crémel G, Genest M, Hubert P, Bagnard D

Oncotarget. 2016 09;7(36):57851-57865

Inhibition of primary breast tumor growth and metastasis using a neuropilin-1 transmembrane domain interfering peptide.

Arpel A, Gamper C, Spenlé C, Fernandez A, Jacob L, Baumlin N, Laquerriere P, Orend G, Crémel G, Bagnard D

Oncotarget. 2016 Aug;7(34):54723-54732

Autonomous Extracellular Matrix Remodeling Controls a Progressive Adaptation in Muscle Stem Cell Regenerative Capacity during Development.

Tierney MT, Gromova A, Sesillo FB, Sala D, Spenlé C, Orend G, Sacco A

Cell Rep. 2016 Mar;14(8):1940-52

Generating and characterizing the mechanical properties of cell-derived matrices using atomic force microscopy.

Tello M, Spenlé C, Hemmerlé J, Mercier L, Fabre R, Allio G, Simon-Assmann P, Goetz JG

Methods. 2016 Feb 1;94:85-100

Spatial organization of the tenascin-C microenvironment in experimental and human cancer.

Spenle C, Gasser I, Saupe F, Janssen KP, Arnold C, Klein A, van der Heyden M, Mutterer J, Neuville-Mechine A, Chenard MP, Guenot D, Esposito I, Slotta-Huspenina J, Ambartsumian N, Simon-Assmann P, Orend G

Cell Adh Migr. 2015 Jan 22:0.

Tenascin-C: exploitation and collateral damage in cancer management.

Spenle C, Saupe F, Midwood K, Burkel H, Noel G, Orend G

Cell Adh Migr. 2015 Jan 8:0.

Transmembrane domain targeting peptide antagonizing ErbB2/Neu inhibits breast tumor growth and metastasis.

Arpel A, Sawma P, Spenle C, Fritz J, Meyer L, Garnier N, Velazquez-Quesada I, Hussenet T, Aci-Seche S, Baumlin N, Genest M, Brasse D, Hubert P, Cremel G, Orend G, Laquerriere P, Bagnard D

Cell Rep. 2014 Sep 25;8(6):1714-21

The laminin response in inflammatory bowel disease: protection or malignancy?

Spenle C, Lefebvre O, Lacroute J, Mechine-Neuville A, Barreau F, Blottiere HM, Duclos B, Arnold C, Hussenet T, Hemmerle J, Gullberg D, Kedinger M, Sorokin L, Orend G, Simon-Assmann P

PLoS One. 2014 Oct 27;9(10):e111336

Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model.

Saupe F, Schwenzer A, Jia Y, Gasser I, Spenle C, Langlois B, Kammerer M, Lefebvre O, Hlushchuk R, Rupp T, Marko M, van der Heyden M, Cremel G, Arnold C, Klein A, Simon-Assmann P, Djonov V, Neuville-Mechine A, Esposito I, Slotta-Huspenina J, Janssen KP, de Wever O, Christofori G, Hussenet T, Orend G

Cell Rep. 2013 Oct 31;5(2):482-92

Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development.

Beucher A, Martin M, Spenle C, Poulet M, Collin C, Gradwohl G

Dev Biol. 2012 Jan 15;361(2):277-85

Role of laminins in physiological and pathological angiogenesis.

Simon-Assmann P, Orend G, Mammadova-Bach E, Spenle C, Lefebvre O

Int J Dev Biol. 2011;55(4-5):455-65.

The role of the basement membrane as a modulator of intestinal epithelial-mesenchymal interactions.

Simon-Assmann P, Spenle C, Lefebvre O, Kedinger M

Prog Mol Biol Transl Sci. 2010;96:175-206.

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