Dr BARRETO Guillermo

Fiche personne

Coordonnées

UMR 7365 CNRS-UL IMoPA
Biopôle de l’Université de Lorraine
Campus Biologie Santé
9 Avenue de la Forêt de Haye
CS 50184
54505 VANDOEUVRE-LES-NANCY

Territoire

Lorraine

Statut

Chercheur

Affiliation

Université de Lorraine (UL)

Équipes/plateformes

UMR 7365 IMoPA - Equipe "Ingénierie Moléculaire, Cellulaire, Thérapeutique & Glycosyltransférases (MolCelTEG)"

Publications

Endothelial RNF20 suppresses endothelial-to-mesenchymal transition and safeguards physiological angiocrine signaling to prevent congenital heart disease.

Dou Y, Tetik-Elsherbiny N, Gao R, Ren Y, Chen YW, Merbecks M, Setya A, Lityagina O, Wang Y, Chichelnitskiy E, Abouissa A, Wu CC, Barreto G, Potente M, Wieland T, Ola R, Grieshaber P, Loukanov T, Gorenflo M, Heineke J, Cordero J, Dobreva G

Nat Commun. 2025 10 27;16(1):9480

Targeting Inflammation and Fibrosis in Cardiovascular Disease: Emerging Mechanisms and Therapies.

Cabrera-Fuentes HA, Barreto G, Perez-Campos E, Nivon-Torres GF, Garcia González AA, Al-Suhaim EA, Liehn EA

FASEB J. 2025 09 15;39(17):e71008

Extracellular RNA Drives TNF-α/TNF-Receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1.

Cabrera-Fuentes HA, Ruiz-Meana M, Barreto G, Serebruany VL, Sánchez-Vega JT, Perez-Campos E, Kostin S, Böning A, González EEJ, Al-Suhaimi EA, Rodriguez-Montesinos J, Inserte J, Pedretti S, Yap J, Irei J, Sedding DG, Lecour S, Liehn EA, Garcia-Dorado D, Hausenloy DJ, Boisvert WA, Preissner KT

Pharmacol Res. 2025 09 12;:107944

B3GALT6 mutations lead to compromised connective tissue biomechanics in Ehlers-Danlos syndrome.

Diana RM, Jolivet B, Vincourt JB, Hergalant S, Francius G, Karami Y, Khakzad H, Wild R, Bourgeais M, Robert A, Wurtz A, Barreto G, Ramalanjaona N, Helle D, Onifarasoaniaina R, Front S, Lopin-Bon C, Syx D, Malfait F, Fournel-Gigleux S, Gulberti S, Bui C

JCI Insight. 2025 08 22;10(16):

RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α.

Liu H, Tang Y, Singh A, Vong J, Cordero J, Mathes A, Gao R, Jia Y, Garvalov BK, Acker T, Poschet G, Hell R, Schneider MA, Heineke J, Wieland T, Barreto G, Cerwenka A, Potente M, Bibli SI, Savai R, Dobreva G

Nat Commun. 2025 05 28;16(1):4929

HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity.

Dobersch S, Yamamoto N, Schutter A, Cavender SM, Robertson TM, Kartha N, Samraj AN, Doron B, Poole LA, Wladyka CL, Zhang A, Jang GH, Mahalingam AH, Barreto G, Raghavan S, Narla G, Notta F, Eisenman RN, Hsieh AC, Kugel S

Nat Commun. 2025 05 26;16(1):4866

Fibroblast plasticity in pulmonary and cardiovascular fibrosis: Mechanistic insights and emerging therapeutic targets.

Cabrera-Fuentes HA, Barreto G, Al-Suhaimi EA, Liehn EA

Arch Med Res. 2025 01 7;56(4):103173

Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-β-induced transcription.

Cordero J, Swaminathan G, Rogel-Ayala DG, Rubio K, Elsherbiny A, Mahmood S, Szymanski W, Graumann J, Braun T, Günther S, Dobreva G, Barreto G

Nat Commun. 2024 12 20;15(1):10711

Genetic variability in proteoglycan biosynthetic genes reveals new facets of heparan sulfate diversity.

Ouidja MO, Biard DSF, Huynh MB, Laffray X, Gomez-Henao W, Chantepie S, Le Douaron G, Rebergue N, Maïza A, Merrick H, De Lichy A, Dady A, González-Velasco O, Rubio K, Barreto G, Baranger K, Cormier-Daire V, De Las Rivas J, Fernig DG, Papy-Garcia D

Essays Biochem. 2024 12 4;68(4):555-578

Implications in Cancer of Nuclear Micro RNAs, Long Non-Coding RNAs, and Circular RNAs Bound by PRC2 and FUS.

Swaminathan G, Rogel-Ayala DG, Armich A, Barreto G

Cancers (Basel). 2024 02 21;16(5):

Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score.

Rubio K, Müller JM, Mehta A, Watermann I, Olchers T, Koch I, Wessels S, Schneider MA, Araujo-Ramos T, Singh I, Kugler C, Stoleriu MG, Kriegsmann M, Eichhorn M, Muley T, Merkel OM, Braun T, Ammerpohl O, Reck M, Tresch A, Barreto G

Discov Oncol. 2023 10 3;14(1):181

F-actin nanostructures rearrangements and regulation are essential for SARS-CoV-2 particle production in host pulmonary cells.

Swain J, Merida P, Rubio K, Bracquemond D, Neyret A, Aguilar-Ordoñez I, Günther S, Barreto G, Muriaux D

iScience. 2023 08 18;26(8):107384

Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer.

Rubio K, Romero-Olmedo AJ, Sarvari P, Swaminathan G, Ranvir VP, Rogel-Ayala DG, Cordero J, Günther S, Mehta A, Bassaly B, Braubach P, Wygrecka M, Gattenlöhner S, Tresch A, Braun T, Dobreva G, Rivera MN, Singh I, Graumann J, Barreto G

Theranostics. 2023 04 17;13(8):2384-2407

Nutriepigenomics in Environmental-Associated Oxidative Stress.

Rubio K, Hernández-Cruz EY, Rogel-Ayala DG, Sarvari P, Isidoro C, Barreto G, Pedraza-Chaverri J

Antioxidants (Basel). 2023 03 21;12(3):

Editorial: Molecular basis of epigenetic regulation in cancer therapies.

Carlos-Reyes A, Romero-Garcia S, López-Camarillo C, Barreto G, Prado-Garcia H

Front Genet. 2023 01 10;13:1115353

Circulating hyaluronic acid signature in CAP and ARDS - the role of pneumolysin in hyaluronic acid shedding.

Sauer A, Seeliger B, Jandl K, Erfinanda L, Wilhelm J, Alexopoulos I, Baal N, Birnhuber A, David S, Welte T, Barreto G, Gaertner U, Kwapiszewska G, Seeger W, Kuebler WM, Schaefer L, Wygrecka M,

Matrix Biol. 2022 12;114:67-83

ADAR1 Isoforms Regulate Processing in Idiopathic Pulmonary Fibrosis.

Díaz-Piña G, Rubio K, Ordoñez-Razo RM, Barreto G, Montes E, Becerril C, Salgado A, Cabrera-Fuentes H, Aquino-Galvez A, Carlos-Reyes A, Ruiz V

Int J Mol Sci. 2022 08 12;23(16):

Impact of the Exposome on the Epigenome in Inflammatory Bowel Disease Patients and Animal Models.

Vieujean S, Caron B, Haghnejad V, Jouzeau JY, Netter P, Heba AC, Ndiaye NC, Moulin D, Barreto G, Danese S, Peyrin-Biroulet L

Int J Mol Sci. 2022 07 9;23(14):

Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs.

Olmedo-Suárez MÁ, Ramírez-Díaz I, Pérez-González A, Molina-Herrera A, Coral-García MÁ, Lobato S, Sarvari P, Barreto G, Rubio K

Biomolecules. 2022 Mar 28;12(4):

Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19.

Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander L, Witzenrath M, Kuebler W, Kwapiszewska G, Preissner KT

Blood Adv. 2021 Dec 3;:

Lymphoid-specific helicase in epigenetics, DNA repair and cancer.

Chen X, Li Y, Rubio K, Deng B, Li Y, Tang Q, Mao C, Liu S, Xiao D, Barreto G, Tao Y

Br J Cancer. 2021 Sep 7;:

Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community acquired pneumonia.

Ehrlich K, Wilhelm J, Markart P, Weisser H, Wolff JC, Bein G, Pak O, Barreto G, Weissmann N, Schramm F, Seeger W, Schaefer L, Kuebler WM, Wygrecka M,

Am J Physiol Lung Cell Mol Physiol. 2021 07 28;:

Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation.

Dobersch S, Rubio K, Singh I, Günther S, Graumann J, Cordero J, Castillo-Negrete R, Huynh MB, Mehta A, Braubach P, Cabrera-Fuentes H, Bernhagen J, Chao CM, Bellusci S, Günther A, Preissner KT, Kugel S, Dobreva G, Wygrecka M, Braun T, Papy-Garcia D, Barreto G

Nat Commun. 2021 02 16;12(1):1072

Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation.

El-Nikhely N, Karger A, Sarode P, Singh I, Weigert A, Wietelmann A, Stiewe T, Dammann R, Fink L, Grimminger F, Barreto G, Seeger W, Pullamsetti SS, Rapp UR, Savai R

Cancer Res. 2020 10 1;80(19):4199-4211

Recognition of breathprints of lung cancer and chronic obstructive pulmonary disease using the Aeonose electronic nose.

Krauss E, Haberer J, Barreto G, Degen M, Seeger W, Guenther A

J Breath Res. 2020 07 24;14(4):046004

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores.

Schnieder J, Mamazhakypov A, Birnhuber A, Wilhelm J, Kwapiszewska G, Ruppert C, Markart P, Wujak L, Rubio K, Barreto G, Schaefer L, Wygrecka M

Matrix Biol. 2020 06;88:69-88

Non-coding RNAs and nuclear architecture during epithelial-mesenchymal transition in lung cancer and idiopathic pulmonary fibrosis.

Rubio K, Castillo-Negrete R, Barreto G

Cell Signal. 2020 06;70:109593

Failure to Down-Regulate Expression in Early Postnatal Mouse Lung Epithelium Suppresses Alveologenesis, with Changes in Tgf-β Signaling Similar to those Induced by Exposure to Hyperoxia.

Chao CM, Carraro G, Rako ZA, Kolck J, Sedighi J, Zimmermann V, Moiseenko A, Wilhelm J, Young BM, Chong L, Wu J, Contreras A, Minoo P, Barreto G, Warburton D, Bellusci S

Cells. 2020 04 2;9(4):

Exploring the Ability of Electronic Nose Technology to Recognize Interstitial Lung Diseases (ILD) by Non-Invasive Breath Screening of Exhaled Volatile Compounds (VOC): A Pilot Study from the European IPF Registry (eurIPFreg) and Biobank.

Krauss E, Haberer J, Maurer O, Barreto G, Drakopanagiotakis F, Degen M, Seeger W, Guenther A

J Clin Med. 2019 Oct 16;8(10):

A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development.

Shrestha A, Carraro G, Nottet N, Vazquez-Armendariz AI, Herold S, Cordero J, Singh I, Wilhelm J, Barreto G, Morty R, El Agha E, Mari B, Chen C, Zhang JS, Chao CM, Bellusci S

Cell Mol Life Sci. 2019 Jul;76(14):2817-2832

Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET.

Jia Y, Vong JS, Asafova A, Garvalov BK, Caputo L, Cordero J, Singh A, Boettger T, Günther S, Fink L, Acker T, Barreto G, Seeger W, Braun T, Savai R, Dobreva G

J Exp Med. 2019 06 3;216(6):1377-1395

Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate.

Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G

Cell Res. 2019 06;29(6):486-501

Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis.

Rubio K, Singh I, Dobersch S, Sarvari P, Günther S, Cordero J, Mehta A, Wujak L, Cabrera-Fuentes H, Chao CM, Braubach P, Bellusci S, Seeger W, Günther A, Preissner KT, Wygrecka M, Savai R, Papy-Garcia D, Dobreva G, Heikenwalder M, Savai-Pullamsetti S, Braun T, Barreto G

Nat Commun. 2019 05 20;10(1):2229

Functional interactions between scaffold proteins, noncoding RNAs, and genome loci induce liquid-liquid phase separation as organizing principle for 3-dimensional nuclear architecture: implications in cancer.

Rubio K, Dobersch S, Barreto G

FASEB J. 2019 05;33(5):5814-5822

Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.

Chao CM, Moiseenko A, Kosanovic D, Rivetti S, El Agha E, Wilhelm J, Kampschulte M, Yahya F, Ehrhardt H, Zimmer KP, Barreto G, Rizvanov AA, Schermuly RT, Reiss I, Morty RE, Rottier RJ, Bellusci S, Zhang JS

Hum Mol Genet. 2019 05 1;28(9):1429-1444

Pioneer Factors and Architectural Proteins Mediating Embryonic Expression Signatures in Cancer.

Dobersch S, Rubio K, Barreto G

Trends Mol Med. 2019 04;25(4):287-302

MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization.

Singh I, Contreras A, Cordero J, Rubio K, Dobersch S, Günther S, Jeratsch S, Mehta A, Krüger M, Graumann J, Seeger W, Dobreva G, Braun T, Barreto G

Nat Genet. 2018 07;50(7):990-1001

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.

Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS, Minoo P, Bellusci S

J Pathol. 2017 Jan;241(1):91-103