Pr PONS Françoise

Fiche personne

Coordonnées

Laboratoire CBST
Faculté de Pharmacie
74 route du Rhin
BP 60024
67401 ILLKIRCH Cedex

03 68 85 42 03

Territoire

Alsace

Statut

Enseignant-Chercheur

Affiliation

Université de Strasbourg (Unistra)

Laboratoire de chémo-biologie synthétique & thérapeutique - UMR 7199 (CBST)

Équipes/plateformes

UMR 7199 - Equipe "Nanoparticules intelligentes (NPI)"

Projets

Conception de constructions liposomales destinées à la vaccination anti-tumorale par voie nasale

2011 - Porteur du projet : Pr PONS Françoise

Publications

Carbon Dots with Tunable Charge as Mucus-Penetrating Gene Carriers.

Arca S, Witjaksono C, Pons F, Lebeau L

Pharmaceutics. 2025 10 14;17(10):

Involvement of Surface Receptors in the Uptake and Cellular Responses Induced by Cationic Polyamine-Based Carbon Dots in Macrophages.

Cerland A, Harmouch E, Rapp M, Lebeau L, Pons F, Ronzani C

Toxics. 2025 08 30;13(9):

Engineered carbon dots for mucosal gene delivery.

Arca S, Pons F, Lebeau L

Eur J Pharm Sci. 2025 07 30;:107222

The interplay between lysosome, protein corona and biological effects of cationic carbon dots: role of surface charge titratability.

Arezki Y, Harmouch E, Delalande F, Rapp M, Schaeffer-Reiss C, Galli O, Cianférani S, Lebeau L, Pons F, Ronzani C

Int J Pharm. 2023 09 6;:123388

Surface charge influences protein corona, cell uptake and biological effects of carbon dots.

Arezki Y, Delalande F, Schaeffer-Reiss C, Cianférani S, Rapp M, Lebeau L, Pons F, Ronzani C

Nanoscale. 2022 09 28;:

Cationic Carbon Nanoparticles Induce Inflammasome-Dependent Pyroptosis in Macrophages Lysosomal Dysfunction.

Arezki Y, Rapp M, Lebeau L, Ronzani C, Pons F

Front Toxicol. 2022 07 19;4:925399

Mucus-producing epithelial models for investigating the activity of gene delivery systems in the lung.

Sonntag T, Rapp M, Didier P, Lebeau L, Pons F, Casset A

Int J Pharm. 2021 Dec 24;:121423

A Co-Culture Model of the Human Respiratory Tract to Discriminate the Toxicological Profile of Cationic Nanoparticles According to Their Surface Charge Density.

Arezki Y, Cornacchia J, Rapp M, Lebeau L, Pons F, Ronzani C

Toxics. 2021 Aug 31;9(9):

Combined In Vitro and In Vivo Approaches to Propose a Putative Adverse Outcome Pathway for Acute Lung Inflammation Induced by Nanoparticles: A Study on Carbon Dots.

Weiss M, Fan J, Claudel M, Lebeau L, Pons F, Ronzani C

Nanomaterials (Basel). 2021 Jan 13;11(1):

Density of surface charge is a more predictive factor of the toxicity of cationic carbon nanoparticles than zeta potential.

Weiss M, Fan J, Claudel M, Sonntag T, Didier P, Ronzani C, Lebeau L, Pons F

J Nanobiotechnology. 2021 Jan 6;19(1):5

Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs.

Gaillard B, Remy JS, Pons F, Lebeau L

Pharm. Res.. 2020 May 27;37(6):106

rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells.

Meng W, Rey-Rico A, Claudel M, Schmitt G, Speicher-Mentges S, Pons F, Lebeau L, Venkatesan JK, Cucchiarini M

Nanomaterials (Basel). 2020 Apr 28;10(5):

Dual Gene Delivery Reagents From Antiproliferative Alkylphospholipids for Combined Antitumor Therapy.

Gaillard B, Remy JS, Pons F, Lebeau L

Front Chem. 2020 ;8:581260

Erufosine (ErPC3) Cationic Prodrugs as Dual Gene Delivery Reagents for Combined Antitumor Therapy.

Gaillard B, Seguin C, Remy JS, Pons F, Lebeau L

Chemistry. 2019 Sep 24;:

Physicochemical characteristics that affect carbon dot safety: lessons from a comprehensive study on a nanoparticle library.

Fan J, Claudel M, Ronzani C, Arezki Y, Lebeau L, Pons F

Int J Pharm. 2019 Jul 16;:118521

Effects of imidazoline-like drugs on liver and adipose tissues, and their role in preventing obesity and associated cardio-metabolic disorders.

Aubertin G, Weiss M, Traversi F, Benameur D, Choquet P, Dali-Youcef N, Pons F, Sigrist S, Greney H, Monassier L, Bousquet P, Niederhoffer N

Int J Obes (Lond). 2019 Mar 29;:

Macrophage functionality and homeostasis in response to oligoethyleneglycol-coated IONPs: impact of a dendritic architecture.

Casset A, Jouhannaud J, Garofalo A, Spiegelhalter C, Nguyen DV, Felder-Flesch D, Pourroy G, Pons F

Int J Pharm. 2018 Dec 14;:

Liposomal constructs for antitumoral vaccination by the nasal route.

Kakhi Z, Frisch B, Heurtault B, Pons F

Biochimie. 2016 Nov;130:14-22

Cationic DOPC-Detergent Conjugates for Safe and Efficient in Vitro and in Vivo Nucleic Acid Delivery.

Pierrat P, Casset A, Didier P, Kereselidze D, Lux M, Pons F, Lebeau L

Chembiochem. 2016 Sep;17(18):1771-83

Enhanced gene delivery to the lung using biodegradable polyunsaturated cationic phosphatidylcholine-detergent conjugates.

Pierrat P, Kereselidze D, Lux M, Lebeau L, Pons F

Int J Pharm. 2016 Sep;511(1):205-18

DOPC-Detergent Conjugates: Fusogenic Carriers for Improved In Vitro and In Vivo Gene Delivery.

Pierrat P, Casset A, Kereselidze D, Lux M, Pons F, Lebeau L

Macromol Biosci. 2016 Jul;16(7):984-9

Airway administration of a highly versatile peptide-based liposomal construct for local and distant antitumoral vaccination.

Kakhi Z, Frisch B, Bourel-Bonnet L, Hemmerlé J, Pons F, Heurtault B

Int J Pharm. 2015 Dec;496(2):1047-56

Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers.

Pierrat P, Wang R, Kereselidze D, Lux M, Didier P, Kichler A, Pons F, Lebeau L

Biomaterials. 2015 May;51:290-302

Bioresponsive deciduous-charge amphiphiles for liposomal delivery of DNA and siRNA.

Pierrat P, Kereselidze D, Wehrung P, Zuber G, Pons F, Lebeau L

Pharm Res. 2013 May;30(5):1362-79

Immunomodulatory properties of multi-walled carbon nanotubes in peripheral blood mononuclear cells from healthy subjects and allergic patients.

Laverny G, Casset A, Purohit A, Schaeffer E, Spiegelhalter C, de Blay F, Pons F

Toxicol. Lett.. 2013 Feb 27;217(2):91-101

Phospholipid-detergent conjugates as novel tools for siRNA delivery.

Pierrat P, Laverny G, Creusat G, Wehrung P, Strub JM, VanDorsselaer A, Pons F, Zuber G, Lebeau L

Chemistry. 2013 Feb 11;19(7):2344-55

A cationic phospholipid-detergent conjugate as a new efficient carrier for siRNA delivery.

Pierrat P, Creusat G, Laverny G, Pons F, Zuber G, Lebeau L

Chemistry. 2012 Mar 26;18(13):3835-9

Lung deposition and toxicological responses evoked by multi-walled carbon nanotubes dispersed in a synthetic lung surfactant in the mouse.

Ronzani C, Spiegelhalter C, Vonesch JL, Lebeau L, Pons F

Arch Toxicol. 2012 Jan;86(1):137-49

Liposomes as delivery systems for nasal vaccination: strategies and outcomes.

Heurtault B, Frisch B, Pons F

Expert Opin Drug Deliv. 2010 Jul;7(7):829-44.

Nucleic acid transfer with hemifluorinated polycationic lipids.

Klein E, Leborgne C, Ciobanu M, Klein J, Frisch B, Pons F, Zuber G, Scherman D, Kichler A, Lebeau L

Biomaterials. 2010 Jun;31(17):4781-8

"HFP" fluorinated cationic lipids for enhanced lipoplex stability and gene delivery.

Klein E, Ciobanu M, Klein J, Machi V, Leborgne C, Vandamme T, Frisch B, Pons F, Kichler A, Zuber G, Lebeau L

Bioconjug Chem. 2010 Feb 17;21(2):360-71.

Design of a liposomal candidate vaccine against Pseudomonas aeruginosa and its evaluation in triggering systemic and lung mucosal immunity.

Heurtault B, Gentine P, Thomann JS, Baehr C, Frisch B, Pons F

Pharm Res. 2009 Feb;26(2):276-85

Small neutralizing molecules to inhibit actions of the chemokine CXCL12.

Hachet-Haas M, Balabanian K, Rohmer F, Pons F, Franchet C, Lecat S, Chow KY, Dagher R, Gizzi P, Didier B, Lagane B, Kellenberger E, Bonnet D, Baleux F, Haiech J, Parmentier M, Frossard N, Arenzana-Seisdedos F, Hibert M, Galzi JL

J Biol Chem. 2008 Aug 22;283(34):23189-99

In vivo evaluation of a reverse water-in-fluorocarbon emulsion stabilized with a semifluorinated amphiphile as a drug delivery system through the pulmonary route.

Courrier HM, Pons F, Lessinger JM, Frossard N, Krafft MP, Vandamme TF

Int J Pharm. 2004 Sep;282(1-2):131-40

Evaluation of cytotoxicity of new semi-fluorinated amphiphiles derived from dimorpholinophosphate.

Courrier HM, Krafft MP, Butz N, Porté C, Frossard N, Rémy-Kristensen A, Mély Y, Pons F, Vandamme TF

Biomaterials. 2003 Feb;24(4):689-96

Triiodothyronine influences quail myoblast proliferation and differentiation.

Marchal S, Cassar-Malek I, Pons F, Wrutniak C, Cabello G

Biol. Cell. 1993 ;78(3):191-7

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