Dr ENNIFAR Eric

Fiche personne

Coordonnées

IBMC
2 allée Conrad Roentgen
67084 STRASBOURG

03 88 41 70 01

Territoire

Alsace

Statut

Chercheur

Affiliation

IBMC - Institut de biologie moléculaire et cellulaire (IBMC)

Équipes/plateformes

CNRS UPR 9002 - Equipe "Architecture et réactivité de l'ARN / Structure, dynamique et ciblage des machines biomoléculaires"

Molecular Biophysics Facility Strasbourg

Recherche

Mots clés : Biologie moléculaire, Biologie structurale, Biophysique

Thématique de recherche :

Structure et dynamique des machines biomoléculaires

Publications

Tailored Watson-Crick Pairing Partners for Xanthosine in RNA.

Micura R, Mair S, Rázková A, Brillet K, Gasser C, Ennifar E

Chemistry. 2025 06 18;:e202501860

A structural element within the 5'UTR of β-catenin mRNA modulates its translation under hypoxia.

D'Agostino M, Rol-Moreno J, Bec G, Kuhn L, Ennifar E, Simonetti A

Nucleic Acids Res. 2025 04 22;53(8):

Principles of ion binding to RNA inferred from the analysis of a 1.55 Å resolution bacterial ribosome structure - Part I: Mg2.

Leonarski F, Henning-Knechtel A, Kirmizialtin S, Ennifar E, Auffinger P

Nucleic Acids Res. 2024 12 5;53(1):

RNA-Puzzles Round V: blind predictions of 23 RNA structures.

Bu F, Adam Y, Adamiak RW, Antczak M, de Aquino BRH, Badepally NG, Batey RT, Baulin EF, Boinski P, Boniecki MJ, Bujnicki JM, Carpenter KA, Chacon J, Chen SJ, Chiu W, Cordero P, Das NK, Das R, Dawson WK, DiMaio F, Ding F, Dock-Bregeon AC, Dokholyan NV, Dror RO, Dunin-Horkawicz S, Eismann S, Ennifar E, Esmaeeli R, Farsani MA, Ferré-D'Amaré AR, Geniesse C, Ghanim GE, Guzman HV, Hood IV, Huang L, Jain DS, Jaryani F, Jin L, Joshi A, Karelina M, Kieft JS, Kladwang W, Kmiecik S, Koirala D, Kollmann M, Kretsch RC, Kurciński M, Li J, Li S, Magnus M, Masquida B, Moafinejad SN, Mondal A, Mukherjee S, Nguyen THD, Nikolaev G, Nithin C, Nye G, Pandaranadar Jeyeram IPN, Perez A, Pham P, Piccirilli JA, Pilla SP, Pluta R, Poblete S, Ponce-Salvatierra A, Popenda M, Popenda L, Pucci F, Rangan R, Ray A, Ren A, Sarzynska J, Sha CM, Stefaniak F, Su Z, Suddala KC, Szachniuk M, Townshend R, Trachman RJ, Wang J, Wang W, Watkins A, Wirecki TK, Xiao Y, Xiong P, Xiong Y, Yang J, Yesselman JD, Zhang J, Zhang Y, Zhang Z, Zhou Y, Zok T, Zhang D, Zhang S, Żyła A, Westhof E, Miao Z

Nat Methods. 2024 12 2;:

The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains.

Vitoria Gomes M, Landwerlin P, Diebold-Durand ML, Shaik TB, Durand A, Troesch E, Weber C, Brillet K, Lemée MV, Decroos C, Dulac L, Antony P, Watrin E, Ennifar E, Golzio C, Romier C

Cell Rep. 2024 09 5;43(9):114656

Structural analysis of neomycin B and kanamycin A binding Aminoglycosides Modifying Enzymes (AME) and bacterial ribosomal RNA.

Revillo Imbernon J, Weibel JM, Ennifar E, Prévost G, Kellenberger E

Mol Inform. 2024 06 10;:e202300339

Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism.

D'Agostino M, Simonetti A, Motta S, Wolff P, Romagnoli A, Piccinini A, Spinozzi F, Di Marino D, La Teana A, Ennifar E

Structure. 2024 03 27;:

Characterization of SLA RNA promoter from dengue virus and its interaction with the viral non-structural NS5 protein.

Brillet K, Janczuk-Richter M, Poon A, Laukart-Bradley J, Ennifar E, Lebars I

Biochimie. 2024 02 24;:

Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA.

Patel AKM, Vilela P, Shaik TB, McEwen AG, Hazemann I, Brillet K, Ennifar E, Hamiche A, Markov GV, Laudet V, Moras D, Klaholz BP, Billas IML

Nucleic Acids Res. 2023 07 28;:

CspA stimulates translation in the cold of its own mRNA by promoting ribosome progression.

Giuliodori AM, Belardinelli R, Duval M, Garofalo R, Schenckbecher E, Hauryliuk V, Ennifar E, Marzi S

Front Microbiol. 2023 02 9;14:1118329

Efficient production of protein complexes in mammalian cells using a poxvirus vector.

Drillien R, Pradeau-Aubreton K, Batisse J, Mezher J, Schenckbecher E, Marguin J, Ennifar E, Ruff M

PLoS One. 2022 12 15;17(12):e0279038

Safe and easy in vitro evaluation of tmRNA-SmpB-mediated trans-translation from ESKAPE pathogenic bacteria.

Thepaut M, Campos-Silva R, Renard E, Barloy-Hubler F, Ennifar E, Boujard D, Gillet R

RNA. 2021 Aug 5;:

The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.

Ramos-Morales E, Bayam E, Del-Pozo-Rodríguez J, Salinas-Giegé T, Marek M, Tilly P, Wolff P, Troesch E, Ennifar E, Drouard L, Godin JD, Romier C

Nucleic Acids Res. 2021 May 31;:

Impact of 3-deazapurine nucleobases on RNA properties.

Bereiter R, Himmelstoß M, Renard E, Mairhofer E, Egger M, Breuker K, Kreutz C, Ennifar E, Micura R

Nucleic Acids Res. 2021 Apr 15;:

Biophysical Studies of the Binding of Viral RNA with the 80S Ribosome Using switchSENSE.

Schenckbecher E, Bec G, Sakamoto T, Meyer B, Ennifar E

Methods Mol Biol. 2021 ;2263:341-350

switchSENSE Technology for Analysis of DNA Polymerase Kinetics.

Bec G, Ennifar E

Methods Mol Biol. 2021 ;2247:145-153

Deflating the RNA Mg bubble. Stereochemistry to the rescue!

Auffinger P, Ennifar E, D'Ascenzo L

RNA. 2020 Dec 2;:

2'--Trifluoromethylated RNA - a powerful modification for RNA chemistry and NMR spectroscopy.

Himmelstoß M, Erharter K, Renard E, Ennifar E, Kreutz C, Micura R

Chem Sci. 2020 Sep 24;11(41):11322-11330

Different views of the dynamic landscape covered by the 5'-hairpin of the 7SK small nuclear RNA.

Brillet K, Martinez-Zapien D, Bec G, Ennifar E, Dock-Bregeon AC, Lebars I

RNA. 2020 May 19;:

Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes.

Werner S, Schmidt L, Marchand V, Kemmer T, Falschlunger C, Sednev MV, Bec G, Ennifar E, Höbartner C, Micura R, Motorin Y, Hildebrandt A, Helm M

Nucleic Acids Res.. 2020 Feb 25;:

Thioguanosine conversion enables mRNA life-time evaluation by RNA sequencing via double metabolic labeling.

Gasser C, Delazer I, Neuner E, Pascher K, Brillet K, Klotz S, Trixl L, Himmelstoß M, Ennifar E, Rieder D, Lusser A, Micura R

Angew. Chem. Int. Ed. Engl.. 2020 Jan 30;:

Analysis of the HIV-1 Genomic RNA Dimerization Initiation Site Binding to Aminoglycoside Antibiotics Using Isothermal Titration Calorimetry.

Bernacchi S, Ennifar E

Methods Mol. Biol.. 2020 ;2113:237-250

Native Electrospray Ionization Mass Spectrometry of RNA-Ligand Complexes.

Wolff P, Ennifar E

Methods Mol. Biol.. 2020 ;2113:111-118

AFFINImeter: A software to analyze molecular recognition processes from experimental data.

Piñeiro Á, Muñoz E, Sabín J, Costas M, Bastos M, Velázquez-Campoy A, Garrido PF, Dumas P, Ennifar E, García-Río L, Rial J, Pérez D, Fraga P, Rodríguez A, Cotelo C

Anal. Biochem.. 2019 Mar 5;:

ITC Studies of Ribosome/Antibiotics Interactions.

Schenckbecher E, Meyer B, Ennifar E

Methods Mol. Biol.. 2019 ;1964:89-98

Thermodynamic and Kinetic Analysis of Isothermal Titration Calorimetry Experiments by Using KinITC in AFFINImeter.

Muñoz E, Sabín J, Rial J, Pérez D, Ennifar E, Dumas P, Piñeiro Á

Methods Mol. Biol.. 2019 ;1964:225-239

Thermodynamics of Molecular Machines Using Incremental ITC.

Meyer B, da Veiga C, Dumas P, Ennifar E

Methods Mol. Biol.. 2019 ;1964:129-140

Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants.

Marek M, Shaik TB, Heimburg T, Chakrabarti A, Lancelot J, Ramos Morales E, Da Veiga C, Kalinin DV, Melesina J, Robaa D, Schmidtkunz K, Suzuki T, Holl R, Ennifar E, Pierce R, Jung M, Sippl W, Romier C

J. Med. Chem.. 2018 Oct 22;:

Thermodynamic study of aptamers binding to their target proteins.

Sakamoto T, Ennifar E, Nakamura Y

Biochimie. 2018 Feb;145:91-97

Crystal structure and fluorescence properties of the iSpinach aptamer in complex with DFHBI.

Fernandez-Millan P, Autour A, Ennifar E, Westhof E, Ryckelynck M

RNA. 2017 12;23(12):1788-1795

Nucleic acid nanomaterials: Silver-wired DNA.

Auffinger P, Ennifar E

Nat Chem. 2017 Sep 22;9(10):932-934

Synthesis, Thermodynamic Properties, and Crystal Structure of RNA Oligonucleotides Containing 5-Hydroxymethylcytosine.

Riml C, Lusser A, Ennifar E, Micura R

J. Org. Chem.. 2017 Aug 4;82(15):7939-7945

Native ESI Mass Spectrometry Can Help to Avoid Wrong Interpretations from Isothermal Titration Calorimetry in Difficult Situations.

Wolff P, Da Veiga C, Ennifar E, Bec G, Guichard G, Burnouf D, Dumas P

J. Am. Soc. Mass Spectrom.. 2017 Feb;28(2):347-357

Multianalytical Study of the Binding between a Small Chiral Molecule and a DNA Aptamer: Evidence for Asymmetric Steric Effect upon 3'- versus 5'-End Sequence Modification.

Challier L, Miranda-Castro R, Barbe B, Fave C, Limoges B, Peyrin E, Ravelet C, Fiore E, Labbé P, Coche-Guérente L, Ennifar E, Bec G, Dumas P, Mavré F, Noël V

Anal. Chem.. 2016 Dec 6;88(23):11963-11971

Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants.

Radi M, Maga G, Alongi M, Angeli L, Samuele A, Zanoli S, Bellucci L, Tafi A, Casaluce G, Giorgi G, Armand-Ugon M, Gonzalez E, Esté JA, Baltzinger M, Bec G, Dumas P, Ennifar E, Botta M

J. Med. Chem.. 2009 Feb 12;52(3):840-51

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