Dr PERRUCHE Sylvain

Fiche personne

Coordonnées

EFS Bourgogne Franche Comte
8 rue du docteur Jean Francois Xavier Girod
25020 BESANCON Cedex

03 81 61 85 26

Territoire

Franche-Comté

Statut

Chercheur

Affiliation

Inserm UMR 1098 "Interaction Hôte-Greffon-Tumeur, Ingénierie Cellulaire et Génique" (Inserm UMR1098 RIGHT)

Équipes/plateformes

UMR 1098 - Equipe "Autoimmunité, Transplantation, et Inflammation (ATI) / Modulation des réponses immunes"

Recherche

Mots clés : Immunology, Inflammation, Transplantation, Innate Immunity

Expertises :
- Recherche:Immunologie

Projets

Résolution de l'inflammation en allogreffe de cellules hématopoïétiques par l'utilisation de cellules apoptotiques et dérivés

2013 - Porteur du projet : Dr PERRUCHE Sylvain

Publications

Metformin dual-targets metabolism and survival pathways in BPDCN.

Mekkaoui Z, Dal Zuffo L, Vetter M, Fredon M, Poussard M, Biichle S, Mougey V, Mercier-Letondal P, Rolin G, Godet Y, Perruche S, Garnache-Ottou F, Saas P, Aribi M

iScience. 2026 07 17;29(7):116323

Macrophages Are Critical Inducers of Bleomycin-Induced Fibrosis in a Systemic Scleroderma Model.

Baffert B, Schneider K, Wetzel A, Dal Zuffo L, Chagué C, Mitifiot E, Bonnefoy F, Kuzniewska A, Saas P, Bamoulid J, Rolin G, Perruche S, Arandjelovic S

Am J Pathol. 2026 02;196(2):460-478

International Society of Cell and Gene Therapy 2025 exosomes signature series: a thematic synthesis for advancing mesenchymal stromal cell-derived extracellular vesicle therapies.

Tertel T, Giebel B, Lee RH, Muraca M, Ortiz LA, Parolini O, Perruche S, Robbins PD, Rohde E, Strader SR, Terai S, Toh WS, Yarani R, Weiss DJ, Wiest EF, Lim SK

Cytotherapy. 2025 11 28;28(3):102016

Fever-range temperature alters continual efferocytosis mediated by mouse pro-inflammatory macrophages.

Vetter M, Maraux M, Bonnefoy F, Dal Zuffo L, Lamarthée B, Rolin G, Wetzel A, Perruche S, Peixoto P, Saas P

J Leukoc Biol. 2025 05 14;:

Clinically relevant cell culture model of inflammatory bowel diseases for identification of new therapeutic approaches.

Antoine T, Béduneau A, Chrétien C, Cornu R, Bonnefoy F, Moulari B, Perruche S, Pellequer Y

Int J Pharm. 2024 12 7;:125062

Macrophage phenotype is determinant for fibrosis development in keloid disease.

Dirand Z, Maraux M, Tissot M, Chatelain B, Supp D, Viennet C, Perruche S, Rolin G

Matrix Biol. 2024 03 12;:

Amelioration of experimental autoimmune encephalomyelitis by in vivo reprogramming of macrophages using pro-resolving factors.

Gauthier T, Martin-Rodriguez O, Chagué C, Daoui A, Ceroi A, Varin A, Bonnefoy F, Valmary-Degano S, Couturier M, Behlke S, Saas P, Cartron PF, Perruche S

J Neuroinflammation. 2023 12 20;20(1):307

Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation.

Saas P, Vetter M, Maraux M, Bonnefoy F, Perruche S

Front Immunol. 2022 10 28;13:1021413

Mini-Review: The Administration of Apoptotic Cells for Treating Rheumatoid Arthritis: Current Knowledge and Clinical Perspectives.

Toussirot E, Bonnefoy F, Vauchy C, Perruche S, Saas P

Front Immunol. 2021 ;12:630170

Pro-Resolving Factor Administration Limits Cancer Progression by Enhancing Immune Response Against Cancer Cells.

Wetzel A, Bonnefoy F, Chagué C, Vetter M, Couturier M, Baffert B, Adotévi O, Saas P, Perruche S

Front Immunol. 2021 ;12:812171

Pro-Resolving Factors Released by Macrophages After Efferocytosis Promote Mucosal Wound Healing in Inflammatory Bowel Disease.

Martin-Rodriguez O, Gauthier T, Bonnefoy F, Couturier M, Daoui A, Chagué C, Valmary-Degano S, Gay C, Saas P, Perruche S

Front Immunol. 2021 ;12:754475

Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators.

Perez-Hernandez J, Chiurchiù V, Perruche S, You S

Front Immunol. 2021 ;12:768133

Photopheresis efficacy in the treatment of rheumatoid arthritis: a pre-clinical proof of concept.

Coppard C, Bonnefoy F, Hannani D, Gabert F, Manches O, Plumas J, Perruche S, Chaperot L

J Transl Med. 2019 Sep 18;17(1):312

Factors Produced by Macrophages Eliminating Apoptotic Cells Demonstrate Pro-Resolutive Properties and Terminate Ongoing Inflammation.

Bonnefoy F, Gauthier T, Vallion R, Martin-Rodriguez O, Missey A, Daoui A, Valmary-Degano S, Saas P, Couturier M, Perruche S

Front Immunol. 2018 ;9:2586

Harnessing Apoptotic Cell Clearance to Treat Autoimmune Arthritis.

Saas P, Bonnefoy F, Toussirot E, Perruche S

Front Immunol. 2017 ;8:1191

Recent insights into the implications of metabolism in plasmacytoid dendritic cell innate functions: Potential ways to control these functions.

Saas P, Varin A, Perruche S, Ceroi A

F1000Res. 2017 ;6:456

LXR agonist treatment of blastic plasmacytoid dendritic cell neoplasm restores cholesterol efflux and triggers apoptosis.

Ceroi A, Masson D, Roggy A, Roumier C, Chagué C, Gauthier T, Philippe L, Lamarthée B, Angelot-Delettre F, Bonnefoy F, Perruche S, Biichle S, Preudhomme C, Macintyre E, Lagrost L, Garnache-Ottou F, Saas P

Blood. 2016 Dec;128(23):2694-2707

Plasmacytoid Dendritic Cells Die by the CD8 T Cell-Dependent Perforin Pathway during Acute Nonviral Inflammation.

Mossu A, Daoui A, Bonnefoy F, Aubergeon L, Saas P, Perruche S

J. Immunol.. 2016 Sep;197(5):1672-82

Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy.

Bonnefoy F, Daoui A, Valmary-Degano S, Toussirot E, Saas P, Perruche S

Arthritis Res. Ther.. 2016 Aug;18(1):184

Concise Review: Apoptotic Cell-Based Therapies-Rationale, Preclinical Results and Future Clinical Developments.

Saas P, Daguindau E, Perruche S

Stem Cells. 2016 Jun;34(6):1464-73

[Proteinase 3: a new danger signal and a double agent in vasculitis].

Witko-Sarsat V, Perruche S

Med Sci (Paris). 2016 May;32(5):450-2

The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation.

Ceroi A, Delettre FA, Marotel C, Gauthier T, Asgarova A, Biichlé S, Duperrier A, Mourey G, Perruche S, Lagrost L, Masson D, Saas P

Haematologica. 2016 Mar;101(3):e72-6

Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.

Millet A, Martin KR, Bonnefoy F, Saas P, Mocek J, Alkan M, Terrier B, Kerstein A, Tamassia N, Satyanarayanan SK, Ariel A, Ribeil JA, Guillevin L, Cassatella MA, Mueller A, Thieblemont N, Lamprecht P, Mouthon L, Perruche S, Witko-Sarsat V

J Clin Invest. 2015 Nov 2;125(11):4107-21

Transforming growth factor-β released by apoptotic white blood cells during red blood cell storage promotes transfusion-induced alloimmunomodulation.

Vallion R, Bonnefoy F, Daoui A, Vieille L, Tiberghien P, Saas P, Perruche S

Transfusion. 2015 Jul;55(7):1721-35

Human monocyte-derived suppressor cells control graft-versus-host disease by inducing regulatory forkhead box protein 3-positive CD8+ T lymphocytes.

Janikashvili N, Trad M, Gautheron A, Samson M, Lamarthee B, Bonnefoy F, Lemaire-Ewing S, Ciudad M, Rekhviashvili K, Seaphanh F, Gaugler B, Perruche S, Bateman A, Martin L, Audia S, Saas P, Larmonier N, Bonnotte B

J Allergy Clin Immunol. 2015 Jun;135(6):1614-24.e4

Apoptotic cell-linked immunoregulation: implications for promoting immune tolerance in transplantation.

Kuang R, Perruche S, Chen W

Cell Biosci. 2015 ;5:27

T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1.

Trad M, Gautheron A, Fraszczak J, Alizadeh D, Larmonier C, LaCasse CJ, Centuori S, Audia S, Samson M, Ciudad M, Bonnefoy F, Lemaire-Ewing S, Katsanis E, Perruche S, Saas P, Bonnotte B

Biomed Res Int. 2015;2015:891236

Prospects of apoptotic cell-based therapies for transplantation and inflammatory diseases.

Saas P, Kaminski S, Perruche S

Immunotherapy. 2013 Oct;5(10):1055-73

IL-22 deficiency in donor T cells attenuates murine acute graft-versus-host disease mortality while sparing the graft-versus-leukemia effect.

Couturier M, Lamarthee B, Arbez J, Renauld JC, Bossard C, Malard F, Bonnefoy F, Mohty M, Perruche S, Tiberghien P, Saas P, Gaugler B

Leukemia. 2013 Jul;27(7):1527-37

L14. Immunomodulatory properties of apoptotic cells.

Perruche S, Saas P

Presse Med. 2013 Apr;42(4 Pt 2):537-43

Intravenous infusion of donor apoptotic leukocytes before transplantation delays allogeneic islet graft rejection through regulatory T cells.

Mougel F, Bonnefoy F, Kury-Paulin S, Borot S, Perruche S, Kantelip B, Penfornis A, Saas P, Kleinclauss F

Diabetes Metab. 2012 Dec;38(6):531-7

Blood product and host: A potentially inflamed relationship? (corrected).

Tiberghien P, Garraud O, Saas P, Muller JY, Perruche S, Noizat-Pirenne F

Transfus Clin Biol. 2012 Jun;19(3):81-3

Phosphatidylserine-expressing cell by-products in transfusion: A pro-inflammatory or an anti-inflammatory effect?

Saas P, Angelot F, Bardiaux L, Seilles E, Garnache-Ottou F, Perruche S

Transfus Clin Biol. 2012 Jun;19(3):90-7

Functions of TGF-beta-exposed plasmacytoid dendritic cells.

Saas P, Perruche S

Crit Rev Immunol. 2012;32(6):529-53.

TGF-beta-exposed plasmacytoid dendritic cells participate in Th17 commitment.

Bonnefoy F, Couturier M, Clauzon A, Remy-Martin JP, Gaugler B, Tiberghien P, Chen W, Saas P, Perruche S

J Immunol. 2011 Jun 1;186(11):6157-64

Plasmacytoid dendritic cells play a major role in apoptotic leukocyte-induced immune modulation.

Bonnefoy F, Perruche S, Couturier M, Sedrati A, Sun Y, Tiberghien P, Gaugler B, Saas P

J Immunol. 2011 May 15;186(10):5696-705

Intravenous apoptotic cell infusion as a cell-based therapy toward improving hematopoietic cell transplantation outcome.

Saas P, Gaugler B, Perruche S

Ann N Y Acad Sci. 2010 Oct;1209:118-26

Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome.

Perruche S, Zhang P, Maruyama T, Bluestone JA, Saas P, Chen W

J Immunol. 2009 Jul 15;183(2):953-61

[CD3-specific antibody-induced T-cell apoptosis and apoptotic cell uptake lead to CD3-specific antibody-induced tolerance].

Perruche S, Saas P

Med Sci (Paris). 2009 Apr;25(4):325-7

Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?

Perruche S, Saas P, Chen W

Arthritis Res Ther. 2009;11(4):R104

Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity.

Toussirot E, Saas P, Deschamps M, Pouthier F, Perrot L, Perruche S, Chabod J, Tiberghien P, Wendling D

Arthritis Res Ther. 2009;11(4):R101

Regulatory T-cell expansion and function do not account for the impaired alloreactivity of ex vivo-expanded T cells.

Montcuquet N, Mercier-Letondal P, Perruche S, Duperrier A, Couturier M, Bouchekioua A, Bonyhadi M, Ferrand C, Tiberghien P, Robinet E

Immunology. 2008 Nov;125(3):320-30

Sirolimus enhances the effect of apoptotic cell infusion on hematopoietic engraftment and tolerance induction.

Bonnefoy F, Masson E, Perruche S, Marandin A, Borg C, Radlovic A, Shipman B, Tiberghien P, Saas P, Kleinclauss F

Leukemia. 2008 Jul;22(7):1430-4

A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells.

Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S, Chen W

Nat. Immunol.. 2008 Jun;9(6):632-40

[Towards the use of intravenous apoptotic leukocyte infusion as a cell-based therapy approach?]

Saas P, Bonnefoy F, Kleinclauss F, Sun Y, Tiberghien P, Gaugler B, Perruche S

Transfus Clin Biol. 2008 Jun;15(3):98-108

CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.

Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W

Nat. Med.. 2008 May;14(5):528-35

Mediators involved in the immunomodulatory effects of apoptotic cells.

Saas P, Bonnefoy F, Kury-Paulin S, Kleinclauss F, Perruche S

Transplantation. 2007 Jul;84(1 Suppl):S31-4

CD4+CD25+ T regulatory cells and TGF-beta in mucosal immune system: the good and the bad.

Chen W, Perruche S, Li J

Curr. Med. Chem.. 2007 ;14(21):2245-9

Association of mixed hematopoietic chimerism with elevated circulating autoantibodies and chronic graft-versus-host disease occurrence.

Perruche S, Marandin A, Kleinclauss F, Angonin R, Fresnay S, Baron MH, Tiberghien P, Saas P

Transplantation. 2006 Feb 27;81(4):573-82.

Intravenous apoptotic spleen cell infusion induces a TGF-beta-dependent regulatory T-cell expansion.

Kleinclauss F, Perruche S, Masson E, de Carvalho Bittencourt M, Biichle S, Remy-Martin JP, Ferrand C, Martin M, Bittard H, Chalopin JM, Seilles E, Tiberghien P, Saas P

Cell Death Differ. 2006 Jan;13(1):41-52.