Détail - canceropole-wordpress

Identification and validation of cilia-associated molecular candidates deregulated in severe asthma.

Devilliers MA, Saber Cherif L, Brisebarre A, Chouquet R, Bralet L, Ancel J, Vivien A, Luczka-Majérus E, Bonnomet A, Lalun N, Taillé C, Dubernard X, Mérol JC, Ruaux C, Polette M, Deslée G, Perotin JM, Dormoy V

Respir Res. 2026 02 9;:

AXL expression to predict resistance to immunotherapy in metastatic non-small cell lung cancer.

Ancel J, Dewolf M, Nawrocki-Raby B, Durlach A, Dalstein V, Lalun N, Dormoy V, Deslée G, Gilles C, Polette M

Lung Cancer. 2025 11 22;210:108853

POU5F1 bridges Hedgehog signaling and epithelial remodeling in COPD.

Petit LMG, Belgacemi R, Mulette P, Brisebarre A, Saber Cherif L, Devilliers MA, Hatoum S, Ancel J, Delepine G, Durlach A, Polette M, Deslée G, Perotin JM, Dormoy V

Front Cell Dev Biol. 2025 07 2;13:1566251

Low-molecular-weight hyaluronic acid improves regeneration of cystic fibrosis airway epithelium.

Adam D, Luczka-Majérus E, Cellier J, Dos Santos-Dietz C, Kileztky C, Bonnomet A, Ruaux C, Sage E, Polette M, Abély M, Coraux C

ERJ Open Res. 2025 07;11(4):

Comparing neutrophil-to-lymphocyte ratio (NLR), absolute neutrophil count (ANC) and derived NLR as predictive biomarkers in first-line immunotherapy for non-small cell lung cancer: a retrospective study.

Longueville E, Dewolf M, Dalstein V, Durlach A, Vivien A, Nawrocki-Raby B, Polette M, Deslée G, Ancel J

Transl Lung Cancer Res. 2025 04 30;14(4):1212-1230

[On your marks, get set, go for the 20th edition of J2R 2024 in Paris!].

Annesi-Maesano I, Bonniaud P, Bouchaud G, Boyer L, Gosset P, Gras D, Guignabert C, Ladjemi MZ, Matecki S, Morelot C, Pilette C, Planes C, Plantier L, Polette M, Si-Tahar M, Taillé C, Zaragosi LE, Vachier I, Mari B, Guibert C,

Rev Mal Respir. 2025 03 11;:

Glypican-3 is a key tuner of the Hedgehog pathway in COPD.

Petit LMG, Saber Cherif L, Devilliers MA, Hatoum S, Ancel J, Delepine G, Durlach A, Dubernard X, Mérol JC, Ruaux C, Polette M, Deslée G, Perotin JM, Dormoy V

Heliyon. 2025 01 15;11(1):e41564

TSLP and TSLPr Expression and Localization in the Airways of COPD and Non-COPD Patients.

Saber Cherif L, Devilliers MA, Perotin JM, Ancel J, Vivien A, Bonnomet A, Delepine G, Durlach A, Polette M, Deslée G, Dormoy V

Eur J Immunol. 2025 01;55(1):e202451480

LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer.

Ponchel T, Loeffler E, Ancel J, Brisebarre A, Lalun N, Dalstein V, Durlach A, Deslée G, Dedieu S, Polette M, Nawrocki-Raby B

Eur J Cell Biol. 2024 12 26;104(1):151475

Peribronchial Inflammatory Cell Assessment in COPD Lung Tissues.

Devilliers MA, Saber Cherif L, Petit LMG, Lalun N, Bonnomet A, Durlach A, Delepine G, Polette M, Perotin JM, Deslée G, Dormoy V

J Cell Mol Med. 2024 11;28(22):e70229

[Triumphant return of the J2R 2023 at Tours: A whirlwind of scientific exchanges and emotion].

Annesi-Maesano I, Bonniaud P, Bouchaud G, Boyer L, Gazzeri S, Gosset P, Gras D, Guibert C, Guignabert C, Mari B, Matecki S, Morélot C, Pilette C, Planes C, Plantier L, Polette M, Si-Tahar M, Taillé C, Vachier I,

Rev Mal Respir. 2024 03;41(3):180-182

Airway epithelial cell cilia transcriptomic dysregulation is associated with the inflammatory phenotype in asthma.

Devilliers MA, Brisebarre A, Petit LMG, Polette M, Deslée G, Djukanović R, Dormoy V, Perotin JM,

Allergy. 2024 02 19;:

Twenty years of EMT: A state of the field from TEMTIA X.

Savagner P, Brabletz T, Cheng C, Gilles C, Hong T, Polette M, Sheng G, Stemmler MP, Thompson EW

Cells Tissues Organs. 2024 01 9;:

Airway ciliated cells in adult lung homeostasis and COPD.

Petit LMG, Belgacemi R, Ancel J, Saber Cherif L, Polette M, Perotin JM, Spassky N, Pilette C, Al Alam D, Deslée G, Dormoy V

Eur Respir Rev. 2023 12 31;32(170):

HER2 Alterations in Non-Small Cell Lung Cancer: Biologico-Clinical Consequences and Interest in Therapeutic Strategies.

Loeffler E, Ancel J, Dalstein V, Deslée G, Polette M, Nawrocki-Raby B

Life (Basel). 2023 12 29;14(1):

Soluble biomarkers to predict clinical outcomes in non-small cell lung cancer treated by immune checkpoints inhibitors.

Ancel J, Dormoy V, Raby BN, Dalstein V, Durlach A, Dewolf M, Gilles C, Polette M, Deslée G

Front Immunol. 2023 05 22;14:1171649

Transcriptomic FHIT/pHER2 signature as a predictive factor of outcome and immunotherapy response in non-small cell lung cancer.

Brisebarre A, Ancel J, Ponchel T, Loeffler E, Germain A, Dalstein V, Dormoy V, Durlach A, Delepine G, Deslée G, Polette M, Nawrocki-Raby B

Front Immunol. 2022 12 5;13:1058531

Ciliogenesis is intrinsically altered in COPD small airways.

Luczka-Majérus E, Bonnomet A, Germain A, Lalun N, Kileztky C, Perotin JM, Deslée G, Delepine G, Polette M, Dormoy V, Coraux C

Eur Respir J. 2022 11 17;:

The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients.

Saber Cherif L, Diabasana Z, Perotin JM, Ancel J, Petit LMG, Devilliers MA, Bonnomet A, Lalun N, Delepine G, Maskos U, Gosset P, Polette M, Muggeo A, Guillard T, Deslée G, Dormoy V

Cells. 2022 09 20;11(19):

Whole-Exome Sequencing of Bronchial Epithelial Cells Reveals a Genetic Print of Airway Remodelling in COPD.

Germain A, Perotin JM, Delepine G, Polette M, Deslée G, Dormoy V

Biomedicines. 2022 07 15;10(7):

Regulation of Tissue Factor by CD44 Supports Coagulant Activity in Breast Tumor Cells.

Villard AV, Genna A, Lambert J, Volpert M, Noël A, Hollier B, Polette M, Vanwynsberghe AM, Gilles C

Cancers (Basel). 2022 07 5;14(13):

[RESPIRenT: Pneumology network of innovation and translational research, a second wind for J2R].

Annesi-Maesano I, Bonniaud P, Bouchaud G, Boyer L, Gazzeri S, Gosset P, Gras D, Guibert C, Guignabert C, Mari B, Matecki S, Morélot C, Pilette C, Planes C, Plantier L, Polette M, Si-Tahar M, Taillé C, Vachier I,

Rev Mal Respir. 2022 Feb 16;:

Nicotinic receptors as SARS-CoV-2 spike co-receptors?

Dormoy V, Perotin JM, Gosset P, Maskos U, Polette M, Deslée G

Med Hypotheses. 2022 Jan;158:110741

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD.

Ancel J, Belgacemi R, Diabasana Z, Perotin JM, Bonnomet A, Dewolf M, Launois C, Mulette P, Deslée G, Polette M, Dormoy V

Diagnostics (Basel). 2021 Aug 31;11(9):

Hypoxia in Lung Cancer Management: A Translational Approach.

Ancel J, Perotin JM, Dewolf M, Launois C, Mulette P, Nawrocki-Raby B, Dalstein V, Gilles C, Deslée G, Polette M, Dormoy V

Cancers (Basel). 2021 Jul 8;13(14):

Primary ciliogenesis is a crucial step for multiciliated cell determinism in the respiratory epithelium.

Belgacemi R, Diabasana Z, Hoarau A, Dubernard X, Mérol JC, Ruaux C, Polette M, Perotin JM, Deslée G, Dormoy V

J Cell Mol Med. 2021 Jun 25;:

Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia.

Diabasana Z, Perotin JM, Belgacemi R, Ancel J, Mulette P, Launois C, Delepine G, Dubernard X, Mérol JC, Ruaux C, Gosset P, Maskos U, Polette M, Deslée G, Dormoy V

Int J Mol Sci. 2021 Jun 22;22(13):

CiliOPD: a ciliopathy-associated COPD endotype.

Perotin JM, Polette M, Deslée G, Dormoy V

Respir Res. 2021 Feb 27;22(1):74

ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer.

Neyrinck-Leglantier D, Lesage J, Blacher S, Bonnomet A, Hunziker W, Noël A, Dormoy V, Nawrocki-Raby B, Gilles C, Polette M

Front Cell Dev Biol. 2021 ;9:749364

Nicotinic Receptor Subunits Atlas in the Adult Human Lung.

Diabasana Z, Perotin JM, Belgacemi R, Ancel J, Mulette P, Delepine G, Gosset P, Maskos U, Polette M, Deslée G, Dormoy V

Int J Mol Sci. 2020 Oct 9;21(20):

Sonic hedgehog signalling as a potential endobronchial biomarker in COPD.

Ancel J, Belgacemi R, Perotin JM, Diabasana Z, Dury S, Dewolf M, Bonnomet A, Lalun N, Birembaut P, Polette M, Deslée G, Dormoy V

Respir. Res.. 2020 Aug 7;21(1):207

Clinical Impact of the Epithelial-Mesenchymal Transition in Lung Cancer as a Biomarker Assisting in Therapeutic Decisions.

Ancel J, Dewolf M, Deslée G, Nawrocky-Raby B, Dalstein V, Gilles C, Polette M

Cells Tissues Organs (Print). 2020 Aug 4;:1-19

EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis.

Genna A, Vanwynsberghe AM, Villard AV, Pottier C, Ancel J, Polette M, Gilles C

Cancers (Basel). 2020 Jun 19;12(6):

FHIT /pHER2 signature in non-small cell lung cancer is predictive of anti-HER2 molecule efficacy.

Da Silva J, Jouida A, Ancel J, Dalstein V, Routhier J, Delepine G, Cutrona J, Jonquet A, Dewolf M, Birembaut P, Deslée G, Polette M, Nawrocki-Raby B

J. Pathol.. 2020 Apr 1;:

Vimentin prevents a miR-dependent negative regulation of tissue factor mRNA during epithelial-mesenchymal transitions and facilitates early metastasis.

Francart ME, Vanwynsberghe AM, Lambert J, Bourcy M, Genna A, Ancel J, Perez-Boza J, Noël A, Birembaut P, Struman I, Polette M, Gilles C

Oncogene. 2020 Mar 10;:

Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD.

Belgacemi R, Luczka E, Ancel J, Diabasana Z, Perotin JM, Germain A, Lalun N, Birembaut P, Dubernard X, Mérol JC, Delepine G, Polette M, Deslée G, Dormoy V

EBioMedicine. 2020 Jan;51:102572

Programmed Death-Ligand 1 and Vimentin: A Tandem Marker as Prognostic Factor in NSCLC.

Ancel J, Birembaut P, Dewolf M, Durlach A, Nawrocki-Raby B, Dalstein V, Delepine G, Blacher S, Deslée G, Gilles C, Polette M

Cancers (Basel). 2019 Sep 22;11(10):

New insights into spectral histopathology: infrared-based scoring of tumour aggressiveness of squamous cell lung carcinomas.

Gaydou V, Polette M, Gobinet C, Kileztky C, Angiboust JF, Birembaut P, Vuiblet V, Piot O

Chem Sci. 2019 Apr 21;10(15):4246-4258

[Phenotypical plasticity and targeted therapies in non-small cell lung carcinomas].

Da Silva J, Dalstein V, Polette M, Nawrocki-Raby B

Rev Mal Respir. 2019 Apr 19;:

Alteration of primary cilia in chronic obstructive pulmonary disease.

Perotin JM, Coraux C, Lagonotte E, Birembaut P, Delepine G, Polette M, Deslée G, Dormoy V

Eur. Respir. J.. 2018 Apr 20;:

Epithelial-Mesenchymal Plasticity and Circulating Tumor Cells: Travel Companions to Metastases.

Francart ME, Lambert J, Vanwynsberghe AM, Thompson EW, Bourcy M, Polette M, Gilles C

Dev. Dyn.. 2017 Apr;:

Zonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.

Lesage J, Suarez-Carmona M, Neyrinck-Leglantier D, Grelet S, Blacher S, Hunziker W, Birembaut P, Noël A, Nawrocki-Raby B, Gilles C, Polette M

FASEB J.. 2017 Apr;31(4):1678-1688

Epithelial to mesenchymal transition and HPV infection in squamous cell oropharyngeal carcinomas: the papillophar study.

Lefevre M, Rousseau A, Rayon T, Dalstein V, Clavel C, Beby-Defaux A, Pretet JL, Soussan P, Polette M, Lacau Saint Guily J, Birembaut P,

Br. J. Cancer. 2017 Jan;116(3):362-369

Vibrational Analysis of Lung Tumor Cell Lines: Implementation of an Invasiveness Scale Based on the Cell Infrared Signatures.

Gaydou V, Polette M, Gobinet C, Kileztky C, Angiboust JF, Manfait M, Birembaut P, Piot O

Anal. Chem.. 2016 Sep;88(17):8459-67

Tissue Factor Induced by Epithelial-Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells.

Bourcy M, Suarez-Carmona M, Lambert J, Francart ME, Schroeder H, Delierneux C, Skrypek N, Thompson EW, Jérusalem G, Berx G, Thiry M, Blacher S, Hollier BG, Noël A, Oury C, Polette M, Gilles C

Cancer Res.. 2016 Jul;76(14):4270-82

The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition.

Grelet S, Andries V, Polette M, Gilles C, Staes K, Martin AP, Kileztky C, Terryn C, Dalstein V, Cheng CW, Shen CY, Birembaut P, Van Roy F, Nawrocki-Raby B

J Pathol. 2015 Sep;237(1):25-37

Soluble factors regulated by epithelial-mesenchymal transition mediate tumour angiogenesis and myeloid cell recruitment.

Suarez-Carmona M, Bourcy M, Lesage J, Leroi N, Syne L, Blacher S, Hubert P, Erpicum C, Foidart JM, Delvenne P, Birembaut P, Noel A, Polette M, Gilles C

J Pathol. 2015 Aug;236(4):491-504

Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition.

Gohy ST, Hupin C, Fregimilicka C, Detry BR, Bouzin C, Gaide Chevronay H, Lecocq M, Weynand B, Ladjemi MZ, Pierreux CE, Birembaut P, Polette M, Pilette C

Eur. Respir. J.. 2015 May;45(5):1258-72

Role of nicotinic acetylcholine receptors in cell proliferation and tumour invasion in broncho-pulmonary carcinomas.

Medjber K, Freidja ML, Grelet S, Lorenzato M, Maouche K, Nawrocki-Raby B, Birembaut P, Polette M, Tournier JM

Lung Cancer. 2015 Mar;87(3):258-64

Cystic fibrosis airway epithelium remodelling: involvement of inflammation.

Adam D, Roux-Delrieu J, Luczka E, Bonnomet A, Lesage J, Merol JC, Polette M, Abely M, Coraux C

J Pathol. 2015 Feb;235(3):408-19

Features of mesenchymal transition in the airway epithelium from chronic rhinosinusitis.

Hupin C, Gohy S, Bouzin C, Lecocq M, Polette M, Pilette C

Allergy. 2014 Nov;69(11):1540-9

Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells.

Joannes A, Grelet S, Duca L, Gilles C, Kileztky C, Dalstein V, Birembaut P, Polette M, Nawrocki-Raby B

Mol Cancer Res. 2014 May;12(5):775-83

Regulation of membrane-type 1 matrix metalloproteinase expression by zonula occludens-2 in human lung cancer cells.

Luczka E, Syne L, Nawrocki-Raby B, Kileztky C, Hunziker W, Birembaut P, Gilles C, Polette M

Clin Exp Metastasis. 2013 Oct;30(7):833-43

Vimentin expression predicts the occurrence of metastases in non small cell lung carcinomas.

Dauphin M, Barbe C, Lemaire S, Nawrocki-Raby B, Lagonotte E, Delepine G, Birembaut P, Gilles C, Polette M

Lung Cancer. 2013 Jul;81(1):117-22

Rapid method of quantification of tight-junction organization using image analysis.

Terryn C, Sellami M, Fichel C, Diebold MD, Gangloff S, Le Naour R, Polette M, Zahm JM

Cytometry A. 2013 Feb;83(2):235-41

A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer.

Bonnomet A, Syne L, Brysse A, Feyereisen E, Thompson EW, Noel A, Foidart JM, Birembaut P, Polette M, Gilles C

Oncogene. 2012 Aug 16;31(33):3741-53

Elastin-derived peptides increase invasive capacities of lung cancer cells by post-transcriptional regulation of MMP-2 and uPA.

Toupance S, Brassart B, Rabenoelina F, Ghoneim C, Vallar L, Polette M, Debelle L, Birembaut P

Clin Exp Metastasis. 2012 Jun;29(5):511-22

Regulation of CXCL8/IL-8 expression by zonula occludens-1 in human breast cancer cells.

Brysse A, Mestdagt M, Polette M, Luczka E, Hunziker W, Noel A, Birembaut P, Foidart JM, Gilles C

Mol Cancer Res. 2012 Jan;10(1):121-32

Epithelial-to-Mesenchymal Transitions and Circulating Tumor Cells.

Bonnomet A, Brysse A, Tachsidis A, Waltham M, Thompson EW, Polette M, Gilles C

J Mammary Gland Biol Neoplasia. 2010 May 7.

Fhit regulates invasion of lung tumor cells.

Joannes A, Bonnomet A, Bindels S, Polette M, Gilles C, Burlet H, Cutrona J, Zahm JM, Birembaut P, Nawrocki-Raby B

Oncogene. 2010 Feb 25;29(8):1203-13

{alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation.

Maouche K, Polette M, Jolly T, Medjber K, Cloez-Tayarani I, Changeux JP, Burlet H, Terryn C, Coraux C, Zahm JM, Birembaut P, Tournier JM

Am J Pathol. 2009 Nov;175(5):1868-82

Video-microscopic imaging of cell spatio-temporal dispersion and migration.

Terryn C, Bonnomet A, Cutrona J, Coraux C, Tournier JM, Nawrocki-Raby B, Polette M, Birembaut P, Zahm JM

Crit Rev Oncol Hematol. 2009 Feb;69(2):144-52

The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression.

Bonnomet A, Polette M, Strumane K, Gilles C, Dalstein V, Kileztky C, Berx G, van Roy F, Birembaut P, Nawrocki-Raby B

Oncogene. 2008 Jun 12;27(26):3692-9

Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells.

Hazgui S, Bonnomet A, Nawrocki-Raby B, Milliot M, Terryn C, Cutrona J, Polette M, Birembaut P, Zahm JM

Respir Res. 2008 Apr 21;9:33.

Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis.

Kedinger V, Alpy F, Baguet A, Polette M, Stoll I, Chenard MP, Tomasetto C, Rio MC

PLoS ONE. 2008;3(10):e3518

Beta-catenin and ZO-1: shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes.

Polette M, Mestdagt M, Bindels S, Nawrocki-Raby B, Hunziker W, Foidart JM, Birembaut P, Gilles C

Cells Tissues Organs. 2007;185(1-3):61-5.

Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).

Rocks N, Paulissen G, Quesada Calvo F, Polette M, Gueders M, Munaut C, Foidart JM, Noel A, Birembaut P, Cataldo D

Br J Cancer. 2006 Mar 13;94(5):724-30.

alpha3alpha5beta2-Nicotinic acetylcholine receptor contributes to the wound repair of the respiratory epithelium by modulating intracellular calcium in migrating cells.

Tournier JM, Maouche K, Coraux C, Zahm JM, Cloez-Tayarani I, Nawrocki-Raby B, Bonnomet A, Burlet H, Lebargy F, Polette M, Birembaut P

Am J Pathol. 2006 Jan;168(1):55-68.

Quantitative videomicroscopic analysis of the sociologic behavior of non-invasive and invasive tumor cell lines.

Zahm JM, Hazgui S, Matos M, Ben Seddik A, Nawrocki Raby B, Polette M, Birembaut P, Bonnet N

Cell Mol Biol (Noisy-le-grand). 2007 Jan 20;52(6):54-60.

Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells.

Mestdagt M, Polette M, Buttice G, Noel A, Ueda A, Foidart JM, Gilles C

Int J Cancer. 2006 Jan 1;118(1):35-42.

3D culture model and computer-assisted videomicroscopy to analyze migratory behavior of noninvasive and invasive bronchial epithelial cells.

Hazgui S, Bonnet N, Cutrona J, Nawrocki-Raby B, Polette M, Chouchane L, Birembaut P, Zahm JM

Am J Physiol Cell Physiol. 2005 Dec;289(6):C1547-52

Prevalence of human papillomaviruses in lung carcinomas: a study of 218 cases.

Coissard CJ, Besson G, Polette MC, Monteau M, Birembaut PL, Clavel CE

Mod Pathol. 2005 Dec;18(12):1606-9.

Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells.

Polette M, Gilles C, Nawrocki-Raby B, Lohi J, Hunziker W, Foidart JM, Birembaut P

Cancer Res. 2005 Sep 1;65(17):7691-8.

Comparison of liquid based cytology and histology for the evaluation of HER-2 status using immunostaining and CISH in breast carcinoma.

Sartelet H, Lagonotte E, Lorenzato M, Duval I, Lechki C, Rigaud C, Cucherousset J, Durlach A, Graesslin O, Abboud P, Doco-Fenzy M, Quereux C, Costa B, Polette M, Munck JN, Birembaut P

J Clin Pathol. 2005 Aug;58(8):864-71.