Fiche personne
Territoire
Alsace
Statut
Chercheur
Équipes/plateformes
Recherche
Thématique de recherche :
ARN non-codants et infections virales
Projets
Characterization of EBV and cellular microRNAs variations in Post-Transplantation Lymphoproliferative Disorders: implication for early diagnosis and development of therapeutical tools
2009 - Porteur du projet : Dr PFEFFER Sébastien
Publications
Field-isolate recombinant tick-borne encephalitis viruses define reporter-stability guidelines for antiviral testing in flaviviruses.
Besson B, Mouton D, Boukenadel Y, Nass T, Park S, Lee N, Li J, Shum D, Smyth R, Becker SC, Meignin C, Pfeffer S
Antiviral Res. 2026 09 2;255:106528
Insights into longevity and virus-driven adaptation from Myotis bat genomes.
Vazquez JM, Lauterbur ME, Mottaghinia S, Gaucherand L, Maesen S, Singer M, Villa S, Bucci M, Fraser D, Gray-Sandoval G, Haidar ZR, Han M, Kohler W, Lama TM, Le Corf A, Loyer C, McMillan D, Li S, Lo J, Rey C, Capel SLR, Slocum K, Sui M, Thomas W, Tyburec JD, Brem R, Miller R, Buchalski M, Vazquez-Medina JP, Pfeffer S, Etienne L, Enard D, Sudmant PH
Nature. 2026 08 26;:
Hydrophilic interaction chromatography and tandem mass spectrometry for the characterization of methylated oligoribonucleotides.
Adouairi K, Farre C, Chaix C, Pfeffer S, Faure K
J Pharm Biomed Anal. 2026 05 4;278:117546
Bat Dicer antiviral role and subcellular localization differ upon alphavirus infection in two distinct species.
Gaucherand L, Marie H, Cremaschi J, Pfeffer S
PLoS Pathog. 2025 12 22;21(12):e1013815
[Cellular RNA-binding proteins during viral infection: known factors and new approaches to identify novel targets].
Pasquier C, Pfeffer S, Girardi E
Med Sci (Paris). 2025 07 7;41(6-7):561-569
Beyond RNAi: How the Dicer protein modulates the antiviral innate immune response in mammalian cells: Mammalian Dicer could regulate the innate immune response in an RNAi-independent manner as a result of losing long dsRNA processive activity.
Gaucherand L, Baldaccini M, Pfeffer S
Bioessays. 2024 09 9;:e2400173
Direct Zeptomole Detection of RNA Biomarkers by Ultrabright Fluorescent Nanoparticles on Magnetic Beads.
Cruz Da Silva E, Gaki P, Flieg F, Messmer M, Gucciardi F, Markovska Y, Reisch A, Fafi-Kremer S, Pfeffer S, Klymchenko AS
Small. 2024 07 16;:e2404167
DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection.
Messmer M, Pierson L, Pasquier C, Djordjevic N, Chicher J, Hammann P, Pfeffer S, Girardi E
Virol J. 2024 03 29;21(1):76
The helicase domain of human Dicer prevents RNAi-independent activation of antiviral and inflammatory pathways.
Baldaccini M, Gaucherand L, Chane-Woon-Ming B, Messmer M, Gucciardi F, Pfeffer S
EMBO J. 2024 01 29;:
Promiscuous splicing-derived hairpins are dominant substrates of tailing-mediated defense of miRNA biogenesis in mammals.
Lee S, Jee D, Srivastava S, Yang A, Ramidi A, Shang R, Bortolamiol-Becet D, Pfeffer S, Gu S, Wen J, Lai EC
Cell Rep. 2023 02 16;42(2):112111
Proteomics-based determination of double stranded RNA interactome reveals known and new factors involved in Sindbis virus infection.
Girardi E, Messmer M, Lopez P, Fender A, Chicher J, Chane-Woon-Ming B, Hammann P, Pfeffer S
RNA. 2022 12 20;:
Post-transcriptional regulation of polycistronic microRNAs.
Vilimova M, Pfeffer S
Wiley Interdiscip Rev RNA. 2022 06 14;:e1749
RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication.
Brugier A, Hafirrassou ML, Pourcelot M, Baldaccini M, Kril V, Couture L, Kümmerer BM, Gallois-Montbrun S, Bonnet-Madin L, Vidalain PO, Delaugerre C, Pfeffer S, Meertens L, Amara A
J Virol. 2022 Mar 10;:e0196221
CD169 macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling.
Camara A, Lavanant AC, Abe J, Desforges HL, Alexandre YO, Girardi E, Igamberdieva Z, Asano K, Tanaka M, Hehlgans T, Pfeffer K, Pfeffer S, Mueller SN, Stein JV, Mueller CG
Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):
Untangling the roles of RNA helicases in antiviral innate immunity.
Baldaccini M, Pfeffer S
PLoS Pathog. 2021 Dec;17(12):e1010072
Cis regulation within a cluster of viral microRNAs.
Vilimova M, Contrant M, Randrianjafy R, Dumas P, Elbasani E, Ojala PM, Pfeffer S, Fender A
Nucleic Acids Res. 2021 Aug 20;:
Human DICER helicase domain recruits PKR and modulates its antiviral activity.
Montavon TC, Baldaccini M, Lefèvre M, Girardi E, Chane-Woon-Ming B, Messmer M, Hammann P, Chicher J, Pfeffer S
PLoS Pathog. 2021 May;17(5):e1009549
Genome-Wide CRISPR-Cas9 Screen Reveals the Importance of the Heparan Sulfate Pathway and the Conserved Oligomeric Golgi Complex for Synthetic Double-Stranded RNA Uptake and Sindbis Virus Infection.
Petitjean O, Girardi E, Ngondo RP, Lupashin V, Pfeffer S
mSphere. 2020 Nov 11;5(6):
Roadblocks and fast tracks: How RNA binding proteins affect the viral RNA journey in the cell.
Girardi E, Pfeffer S, Baumert TF, Majzoub K
Semin. Cell Dev. Biol.. 2020 Aug 23;:
Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation.
Ghosh S, Guimaraes JC, Lanzafame M, Schmidt A, Syed AP, Dimitriades B, Börsch A, Ghosh S, Mittal N, Montavon T, Correia AL, Danner J, Meister G, Terracciano LM, Pfeffer S, Piscuoglio S, Zavolan M
EMBO J.. 2020 Aug 19;:e103922
High-throughput fluorescence-based screen identifies the neuronal microRNA miR-124 as a positive regulator of alphavirus infection.
López P, Girardi E, Mounce BC, Weiss A, Chane-Woon-Ming B, Messmer M, Kaukinen P, Kopp A, Bortolamiol-Becet D, Fendri A, Vignuzzi M, Brino L, Pfeffer S
J. Virol.. 2020 Feb 26;:
HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway.
Spaety ME, Gries A, Badie A, Venkatasamy A, Romain B, Orvain C, Yanagihara K, Okamoto K, Jung AC, Mellitzer G, Pfeffer S, Gaiddon C
Cancers (Basel). 2019 Nov 7;11(11):
Functional microRNA screen uncovers O-linked N-acetylglucosamine transferase as a host factor modulating hepatitis C virus morphogenesis and infectivity.
Herzog K, Bandiera S, Pernot S, Fauvelle C, Jühling F, Weiss A, Bull A, Durand SC, Chane-Woon-Ming B, Pfeffer S, Mercey M, Lerat H, Meunier JC, Raffelsberger W, Brino L, Baumert TF, Zeisel MB
Gut. 2019 May 10;:
On the Importance of Host MicroRNAs During Viral Infection.
Girardi E, López P, Pfeffer S
Front Genet. 2018 ;9:439
Reduced DICER1 Expression Bestows Rheumatoid Arthritis Synoviocytes Proinflammatory Properties and Resistance to Apoptotic Stimuli.
Alsaleh G, Nehmar R, Blüml S, Schleiss C, Ostermann E, Dillenseger JP, Sayeh A, Choquet P, Dembele D, Francois A, Salmon JH, Paul N, Schabbauer G, Bierry G, Meyer A, Gottenberg JE, Haas G, Pfeffer S, Vallat L, Sibilia J, Bahram S, Georgel P
. 2016 Aug;68(8):1839-48
Identification of factors involved in target RNA-directed microRNA degradation.
Haas G, Cetin S, Messmer M, Chane-Woon-Ming B, Terenzi O, Chicher J, Kuhn L, Hammann P, Pfeffer S
Nucleic Acids Res.. 2016 Apr;44(6):2873-87
The expression of a viral microRNA is regulated by clustering to allow optimal B cell transformation.
Haar J, Contrant M, Bernhardt K, Feederle R, Diederichs S, Pfeffer S, Delecluse HJ
Nucleic Acids Res.. 2016 Feb;44(3):1326-41
Modulation of MicroRNA Cluster miR-183-96-182 Expression by Epstein-Barr Virus Latent Membrane Protein 1.
Oussaief L, Fendri A, Chane-Woon-Ming B, Poirey R, Delecluse HJ, Joab I, Pfeffer S
J Virol. 2015 Dec 1;89(23):12178-88
Small RNA deep sequencing identifies viral microRNAs during malignant catarrhal fever induced by alcelaphine herpesvirus 1.
Sorel O, Tuddenham L, Myster F, Palmeira L, Kerkhofs P, Pfeffer S, Vanderplasschen A, Dewals BG
J Gen Virol. 2015 Aug 28
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.
Mailly L, Xiao F, Lupberger J, Wilson GK, Aubert P, Duong FH, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lutgehetmann M, Volz T, Davis C, Harris HJ, Mee CJ, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim MH, Neunlist M, Zeisel MB, Dandri M, McKeating JA, Robinet E, Baumert TF
Nat Biotechnol. 2015 Mar 23
miR-122--a key factor and therapeutic target in liver disease.
Bandiera S, Pfeffer S, Baumert TF, Zeisel MB
J Hepatol. 2015 Feb;62(2):448-57
Cross-species comparative analysis of Dicer proteins during Sindbis virus infection.
Girardi E, Lefevre M, Chane-Woon-Ming B, Paro S, Claydon B, Imler JL, Meignin C, Pfeffer S
Sci Rep. 2015 May 29;5:10693
Small RNA cloning and sequencing strategy affects host and viral microRNA expression signatures.
Stik G, Muylkens B, Coupeau D, Laurent S, Dambrine G, Messmer M, Chane-Woon-Ming B, Pfeffer S, Rasschaert D
J Biotechnol. 2014 Jul 10;181:35-44
Importance of the RNA secondary structure for the relative accumulation of clustered viral microRNAs.
Contrant M, Fender A, Chane-Woon-Ming B, Randrianjafy R, Vivet-Boudou V, Richer D, Pfeffer S
Nucleic Acids Res. 2014;42(12):7981-96
MiR-30a-3p negatively regulates BAFF synthesis in systemic sclerosis and rheumatoid arthritis fibroblasts.
Alsaleh G, Francois A, Philippe L, Gong YZ, Bahram S, Cetin S, Pfeffer S, Gottenberg JE, Wachsmann D, Georgel P, Sibilia J
PLoS One. 2014 Oct 31;9(10):e111266
miRNAs at the heart of host-pathogen interactions.
Contrant M, Fender A, Pfeffer S
Virologie. 2013 Nov-dec;17(6):414-25.
MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes.
Philippe L, Alsaleh G, Pichot A, Ostermann E, Zuber G, Frisch B, Sibilia J, Pfeffer S, Bahram S, Wachsmann D, Georgel P
Ann Rheum Dis. 2013 Jun;72(6):1071-9
miR-122 acts as a tumor suppressor in hepatocarcinogenesis in vivo.
Zeisel MB, Pfeffer S, Baumert TF
J Hepatol. 2013 Apr;58(4):821-3
Identification of RNase L-dependent, 3'-end-modified, viral small RNAs in Sindbis virus-infected mammalian cells.
Girardi E, Chane-Woon-Ming B, Messmer M, Kaukinen P, Pfeffer S
MBio. 2013 Nov 19;4(6):e00698-13
The miR-17 approximately 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis.
Philippe L, Alsaleh G, Bahram S, Pfeffer S, Georgel P
Front Immunol. 2013;4:70
The oncogenic microRNA OncomiR-21 overexpressed during Marek's disease lymphomagenesis is transactivated by the viral oncoprotein Meq.
Stik G, Dambrine G, Pfeffer S, Rasschaert D
J Virol. 2013 Jan;87(1):80-93
Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells.
Da Costa D, Turek M, Felmlee DJ, Girardi E, Pfeffer S, Long G, Bartenschlager R, Zeisel MB, Baumert TF
J Virol. 2012 Nov;86(21):11919-25
Deregulation of type I IFN-dependent genes correlates with increased susceptibility to cytomegalovirus acute infection of dicer mutant mice.
Ostermann E, Tuddenham L, Macquin C, Alsaleh G, Schreiber-Becker J, Tanguy M, Bahram S, Pfeffer S, Georgel P
PLoS One. 2012;7(8):e43744
TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes.
Philippe L, Alsaleh G, Suffert G, Meyer A, Georgel P, Sibilia J, Wachsmann D, Pfeffer S
J Immunol. 2012 Jan 1;188(1):454-61
Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis.
Suffert G, Malterer G, Hausser J, Viiliainen J, Fender A, Contrant M, Ivacevic T, Benes V, Gros F, Voinnet O, Zavolan M, Ojala PM, Haas JG, Pfeffer S
PLoS Pathog. 2011 Dec;7(12):e1002405
Roles and regulation of microRNAs in cytomegalovirus infection.
Tuddenham L, Pfeffer S
Biochim Biophys Acta. 2011 Nov-Dec;1809(11-12):613-22
Detection of viral microRNA with S1 nuclease protection assay.
John M, Pfeffer S
Methods Mol Biol. 2011;721:173-82.
miR-346 controls release of TNF-alpha protein and stability of its mRNA in rheumatoid arthritis via tristetraprolin stabilization.
Semaan N, Frenzel L, Alsaleh G, Suffert G, Gottenberg JE, Sibilia J, Pfeffer S, Wachsmann D
PLoS One. 2011;6(5):e19827
RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila.
Mueller S, Gausson V, Vodovar N, Deddouche S, Troxler L, Perot J, Pfeffer S, Hoffmann JA, Saleh MC, Imler JL
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19390-5
Impact of microRNAs for pathogenesis and treatment of hepatitis C virus infection.
Pfeffer S, Baumert TF
Gastroenterol Clin Biol. 2010 Sep;34(8-9):431-5
RNA silencing as a natural antiviral defense system in mammals: where are we now?
Pfeffer S
Mol Ther. 2010 May;18(5):871-2.
Antagonizing microRNA-122 and treatment of hepatitis C virus infection.
Pfeffer S, Baumert TF
Hepatology. 2010 Apr;51(4):1461-3.
Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assay.
Dolken L, Malterer G, Erhard F, Kothe S, Friedel CC, Suffert G, Marcinowski L, Motsch N, Barth S, Beitzinger M, Lieber D, Bailer SM, Hoffmann R, Ruzsics Z, Kremmer E, Pfeffer S, Zimmer R, Koszinowski UH, Grasser F, Meister G, Haas J
Cell Host Microbe. 2010 Apr 22;7(4):324-34.
Post-transcriptional regulation of miR-27 in murine cytomegalovirus infection.
Buck AH, Perot J, Chisholm MA, Kumar DS, Tuddenham L, Cognat V, Marcinowski L, Dolken L, Pfeffer S
RNA. 2010 Feb;16(2):307-15
Cytomegalovirus microRNAs facilitate persistent virus infection in salivary glands.
Dolken L, Krmpotic A, Kothe S, Tuddenham L, Tanguy M, Marcinowski L, Ruzsics Z, Elefant N, Altuvia Y, Margalit H, Koszinowski UH, Jonjic S, Pfeffer S
PLoS Pathog. 2010 Oct 14;6(10):e1001150.
Unravelling the importance of microRNAs during hepatitis C virus infection in the human liver.
Pfeffer S, Baumert TF
J Hepatol. 2009 Sep;51(3):606-9
Bruton's tyrosine kinase is involved in miR-346-related regulation of IL-18 release by lipopolysaccharide-activated rheumatoid fibroblast-like synoviocytes.
Alsaleh G, Suffert G, Semaan N, Juncker T, Frenzel L, Gottenberg JE, Sibilia J, Pfeffer S, Wachsmann D
J Immunol. 2009 Apr 15;182(8):5088-97.
A human snoRNA with microRNA-like functions.
Ender C, Krek A, Friedlander MR, Beitzinger M, Weinmann L, Chen W, Pfeffer S, Rajewsky N, Meister G
Mol Cell. 2008 Nov 21;32(4):519-28.
Viral miRNAs: tiny but mighty helpers for large and small DNA viruses
Pfeffer S
Future Virol. 2008 May;3(3):291-9
Mouse cytomegalovirus microRNAs dominate the cellular small RNA profile during lytic infection and show features of posttranscriptional regulation.
Dolken L, Perot J, Cognat V, Alioua A, John M, Soutschek J, Ruzsics Z, Koszinowski U, Voinnet O, Pfeffer S
J Virol. 2007 Dec;81(24):13771-82
Cellular cofactors affecting hepatitis C virus infection and replication.
Randall G, Panis M, Cooper JD, Tellinghuisen TL, Sukhodolets KE, Pfeffer S, Landthaler M, Landgraf P, Kan S, Lindenbach BD, Chien M, Weir DB, Russo JJ, Ju J, Brownstein MJ, Sheridan R, Sander C, Zavolan M, Tuschl T, Rice CM
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12884-9
A mammalian microRNA expression atlas based on small RNA library sequencing.
Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T
Cell. 2007 Jun 29;129(7):1401-14.
A novel class of small RNAs bind to MILI protein in mouse testes.
Aravin A, Gaidatzis D, Pfeffer S, Lagos-Quintana M, Landgraf P, Iovino N, Morris P, Brownstein MJ, Kuramochi-Miyagawa S, Nakano T, Chien M, Russo JJ, Ju J, Sheridan R, Sander C, Zavolan M, Tuschl T
Nature. 2006 Jul 13;442(7099):203-7
Cloning of small RNA molecules.
Pfeffer S, Lagos-Quintana M, Tuschl T
Curr Protoc Mol Biol. 2005 Nov;Chapter 26:Unit 26.4.
Clustering and conservation patterns of human microRNAs.
Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H
Nucleic Acids Res. 2005 May 12;33(8):2697-706. Print 2005.
Identification of clustered microRNAs using an ab initio prediction method.
Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
BMC Bioinformatics. 2005 Nov 7;6:267.
