Pr MULLER Sylviane

Peptide-mediated inhibition of aberrant chaperone-mediated autophagy in pericytes prevents glioblastoma progression through MAPT/tau secretion.

Salinas MD, Martínez IM, Naranjo E, Molina ML, Cuervo AM, Muller S, Valdor R

Autophagy. 2026 05 18;:1-26

Autoimmunity, diet and autophagy.

Blaise S, Muller S

Autoimmun Rev. 2026 03 20;:104040

Pathophysiological effects of long COVID-19 (auto)antibodies on fertility.

Talamini L, Verdot C, Shoenfeld Y, Muller S

J Autoimmun. 2025 12 24;158:103518

Long COVID-19 autoantibodies and their potential effect on fertility.

Talamini L, Fonseca DLM, Kanduc D, Chaloin O, Verdot C, Galmiche C, Dotan A, Filgueiras IS, Borghi MO, Meroni PL, Gavrilova NY, Ryabkova VA, Churilov LP, Halpert G, Lensch C, Thurner L, Fong SW, Ng LFP, Rénia L, Young BE, Lye DC, Lozano JM, Cabral-Marques O, Shoenfeld Y, Muller S

Front Immunol. 2025 05 27;16:1540341

Autophagy in myositis, a dysregulated pathway, and a target for therapy.

Kamalanathan AS, Agarwal V, Talamini L, Muller S

Autoimmun Rev. 2025 04 20;:103817

Inclusion body myositis: Correcting mitochondfrial and lysosomal autophagy impairment as a potential therapeutic strategy.

Brady S, Poulton J, Muller S

Autoimmun Rev. 2024 09 19;:103644

Hetero-Diels-Alder and CuAAC Click Reactions for Fluorine-18 Labeling of Peptides: Automation and Comparative Study of the Two Methods.

Maujean T, Ramanoudjame SM, Riché S, Le Guen C, Boisson F, Muller S, Bonnet D, Gulea M, Marchand P

Molecules. 2024 07 5;29(13):

HSPA8 chaperone complex drives chaperone-mediated autophagy regulation in acute promyelocytic leukemia cell differentiation.

Rafiq S, Mungure I, Banz Y, Niklaus NJ, Kaufmann T, Müller S, Jacquel A, Robert G, Auberger P, Torbett BE, Muller S, Tschan MP, Humbert M

Pharmacology. 2024 04 3;:

Pharmacological targets at the lysosomal autophagy-NLRP3 inflammasome crossroads.

Bonam SR, Mastrippolito D, Georgel P, Muller S

Trends Pharmacol Sci. 2023 12 14;:

Shared Pathogenicity Features and Sequences between EBV, SARS-CoV-2, and HLA Class I Molecule-binding Motifs with a Potential Role in Autoimmunity.

Adiguzel Y, Mahroum N, Muller S, Blank M, Halpert G, Shoenfeld Y

Clin Rev Allergy Immunol. 2023 07 28;:

Immunological and translational key challenges in systemic lupus erythematosus: A symposium update.

Renaudineau Y, Muller S, Hedrich CM, Chauveau D, Bellière J, De Almeida S, Damoiseaux J, Scherlinger M, Guery JC, Sailler L, Bost C

J Transl Autoimmun. 2023 03 31;6:100199

The abscopal effect: Implications for drug discovery in autoimmunity.

Muller S

Autoimmun Rev. 2023 03 14;:103315

The role of lysosomes in metabolic and autoimmune diseases.

Gros F, Muller S

Nat Rev Nephrol. 2023 03 9;:

Monkeypox: potential vaccine development strategies.

Lozano JM, Muller S

Trends Pharmacol Sci. 2023 01;44(1):15-19

The Therapeutic Effect of Phosphopeptide P140 Attenuates Inflammation Induced by Uric Acid Crystals in Gout Arthritis Mouse Model.

Galvão I, Mastrippolito D, Talamini L, Aganetti M, Rocha V, Verdot C, Mendes V, de Oliveira VLS, Braga AD, Martins VD, de Faria AMC, Amaral FA, Georgel P, Vieira AT, Muller S

Cells. 2022 11 22;11(23):

Autoantibodies against SUMO1-DHX35 in long-COVID.

Thurner L, Fadle N, Regitz E, Preuss KD, Neumann F, Cetin O, Schormann C, Hoffmann MC, Herr C, Kheiroddin P, Rixecker TM, Bals R, Muller S, Thurner B, Kessel C, Kabesch M, Bewarder M, Heyne K, Lensch C, Kos IA

J Transl Autoimmun. 2022 11 20;5:100171

Therapeutic effects of peptide P140 in a mouse periodontitis model.

Akiyama K, Aung KT, Talamini L, Huck O, Kuboki T, Muller S

Cell Mol Life Sci. 2022 09 15;79(10):518

LL-37, a Multi-Faceted Amphipathic Peptide Involved in NETosis.

Radic M, Muller S

Cells. 2022 08 8;11(15):

P140 Peptide Leads to Clearance of Autoreactive Lymphocytes and Normalizes Immune Response in Lupus-Prone Mice.

Schall N, Talamini L, Wilhelm M, Jouvin-Marche E, Muller S

Front Immunol. 2022 06 1;13:904669

Targeting the endo-lysosomal autophagy pathway to treat inflammatory bowel diseases.

Retnakumar SV, Geesala R, Bretin A, Tourneur-Marsille J, Ogier-Denis E, Maretzky T, Thu Nguyen HT, Muller S

J Autoimmun. 2022 Mar 14;128:102814

Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson's Disease.

Bonam SR, Tranchant C, Muller S

Cells. 2021 12 15;10(12):

An Autophagy Modulator Peptide Prevents Lung Function Decrease and Corrects Established Inflammation in Murine Models of Airway Allergy.

Daubeuf F, Schall N, Petit-Demoulière N, Frossard N, Muller S

Cells. 2021 Sep 18;10(9):

Lysosomes in acute myeloid leukemia: potential therapeutic targets?

Rafiq S, McKenna SL, Muller S, Tschan MP, Humbert M

Leukemia. 2021 Aug 30;:

Molecular mimicry between SARS-CoV-2 and the female reproductive system.

Dotan A, Kanduc D, Muller S, Makatsariya A, Shoenfeld Y

Am J Reprod Immunol. 2021 Aug 18;:

Implication of a lysosomal antigen in the pathogenesis of lupus erythematosus.

Wilhelm M, Bonam SR, Schall N, Bendorius M, Korganow AS, Lumbroso C, Muller S

J Autoimmun. 2021 Apr 28;120:102633

Immunologically Inert Nanostructures as Selective Therapeutic Tools in Inflammatory Diseases.

Talamini L, Matsuura E, De Cola L, Muller S

Cells. 2021 Mar 23;10(3):

The SARS-CoV-2 as an instrumental trigger of autoimmunity.

Dotan A, Muller S, Kanduc D, David P, Halpert G, Shoenfeld Y

Autoimmun Rev. 2021 Feb 18;:102792

A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice.

Schall N, Daubeuf F, Marsol C, Gizzi P, Frossard N, Bonnet D, Galzi JL, Muller S

Front Pharmacol. 2021 ;12:752194

Autophagy as an emerging target for COVID-19: lessons from an old friend, chloroquine.

Bonam SR, Muller S, Bayry J, Klionsky DJ

Autophagy. 2020 Jun 10;:

Progress and Challenges in The Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo.

Bonam SR, Bayry J, Tschan MP, Muller S

Cells. 2020 05 25;9(5):

Correction of autophagy impairment inhibits pathology in the NOD.H-2h4 mouse model of primary Sjögren's syndrome.

Voynova E, Lefebvre F, Qadri A, Muller S

J. Autoimmun.. 2020 Feb 3;:102418

Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19.

Narasaraju T, Tang BM, Herrmann M, Muller S, Chow VTK, Radic M

Front Pharmacol. 2020 ;11:870

Lysosomes as a therapeutic target.

Bonam SR, Wang F, Muller S

Nat Rev Drug Discov. 2019 Sep 2;:

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates.

Bonam SR, Ruff M, Muller S

Cells. 2019 Aug 7;8(8):

Novel trisaccharide based phospholipids as immunomodulators.

Bonam SR, Bhunia D, Muller S, Nerella SG, Alvala M, Halmuthur Mahabalarao SK

Int. Immunopharmacol.. 2019 Jun 11;74:105684

Pharmacological Autophagy Regulators as Therapeutic Agents for Inflammatory Bowel Diseases.

Retnakumar SV, Muller S

Trends Mol Med. 2019 Apr 2;:

Blocking nuclear export of HSPA8 after heat shock stress severely alters cell survival.

Wang F, Bonam SR, Schall N, Kuhn L, Hammann P, Chaloin O, Madinier JB, Briand JP, Page N, Muller S

Sci Rep. 2018 Nov 14;8(1):16820

From Systemic Inflammation to Neuroinflammation: The Case of Neurolupus.

Bendorius M, Po C, Muller S, Jeltsch-David H

Int J Mol Sci. 2018 Nov 13;19(11):

Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option.

Bonam SR, Wang F, Muller S

J. Autoimmun.. 2018 Sep 12;:

ATG5 is required for B cell polarization and presentation of particulate antigens.

Arbogast F, Arnold J, Hammann P, Kuhn L, Chicher J, Murera D, Weishaar J, Muller S, Fauny JD, Gros F

Autophagy. 2018 Sep 8;:

Excipients: not so inert? When the excipient plays the role of an active substance, as exemplified by systemic lupus.

Muller S

Swiss Med Wkly. 2018 Jun 25;148:w14631

What has come out from phytomedicines and herbal edibles for the treatment of cancer?

Bonam SR, Wu Yuan S, Tunki L, Chellian R, Halmuthur M SK, Muller S, Pandy V

ChemMedChem. 2018 Jun 21;:

An autophagy-targeting peptide to treat chronic inflammatory demyelinating polyneuropathies.

Brun S, Schall N, Bonam SR, Bigaut K, Mensah-Nyagan AG, de Sèze J, Muller S

J. Autoimmun.. 2018 Jun 5;:

CD4 T cell autophagy is integral to memory maintenance.

Murera D, Arbogast F, Arnold J, Bouis D, Muller S, Gros F

Sci Rep. 2018 Apr 13;8(1):5951

Lupus regulator peptide P140 represses B-cell differentiation by reducing HLA class II molecule overexpression.

Wilhelm M, Wang F, Schall N, Kleinmann JF, Faludi M, Nashi EP, Sibilia J, Martin T, Schaeffer E, Muller S

. 2018 Mar 2;:

Receptor-ligand and parasite protein-protein interactions in Plasmodium vivax: Analysing rhoptry neck proteins 2 and 4.

Bermúdez M, Arévalo-Pinzón G, Rubio L, Chaloin O, Muller S, Curtidor H, Patarroyo MA

Cell. Microbiol.. 2018 Feb 27;:e12835

Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide.

Li B, Wang F, Schall N, Muller S

J. Autoimmun.. 2018 Feb 24;:

The Mitochondrion-lysosome Axis in Adaptive and Innate Immunity: Effect of Lupus Regulator Peptide P140 on Mitochondria Autophagy and NETosis.

Bendorius M, Neeli I, Wang F, Bonam SR, Dombi E, Buron N, Borgne-Sanchez A, Poulton J, Radic M, Muller S

Front Immunol. 2018 ;9:2158

Assessing Autophagy in Sciatic Nerves of a Rat Model that Develops Inflammatory Autoimmune Peripheral Neuropathies.

Brun S, Schall N, Jeltsch-David H, Sèze J, Muller S

Cells. 2017 Sep;6(3):

TREM-1 inhibition restores impaired autophagy activity and reduces colitis in mice.

Kökten T, Gibot S, Lepage P, D'Alessio S, Hablot J, Ndiaye NC, Busby-Venner H, Monot C, Garnier B, Moulin D, Jouzeau JY, Hansmannel F, Danese S, Guéant JL, Muller S, Peyrin-Biroulet L

J Crohns Colitis. 2017 Sep;:

An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy.

Bonam SR, Partidos CD, Halmuthur SKM, Muller S

Trends Pharmacol. Sci.. 2017 Jun;:

Assessing Autophagy in Mouse Models and Patients with Systemic Autoimmune Diseases.

Wang F, Li B, Schall N, Wilhelm M, Muller S

Cells. 2017 Jun;6(3):

Autophagy in neuroinflammatory diseases.

Muller S, Brun S, René F, de Sèze J, Loeffler JP, Jeltsch-David H

Autoimmun Rev. 2017 May;:

[Autophagy, autoimmunity and autoimmune diseases].

Muller S

Med Sci (Paris). 2017 Mar;33(3):319-327

Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide.

Maueröder C, Schall N, Meyer F, Mahajan A, Garnier B, Hahn J, Kienhöfer D, Hoffmann MH, Muller S

Front Immunol. 2017 ;8:16

Autoimmunity, neuroinflammation, pathogen load: A decisive crosstalk in neuropsychiatric SLE.

Jeltsch-David H, Muller S

J. Autoimmun.. 2016 Nov;74:13-26

Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses.

Arnold J, Murera D, Arbogast F, Fauny JD, Muller S, Gros F

Cell Death Differ.. 2016 May;23(5):853-64

Ikaros Is a Negative Regulator of B1 Cell Development and Function.

Macias-Garcia A, Heizmann B, Sellars M, Marchal P, Dali H, Pasquali JL, Muller S, Kastner P, Chan S

J. Biol. Chem.. 2016 Apr;291(17):9073-86

[Autophagy in T and B cell homeostasis: recycling for sustainable growth].

Arnold J, Murera D, Arbogast F, Muller S, Gros F

Med Sci (Paris). 2016 Mar;32(3):281-9

Oxidation and mitochondrial origin of NET DNA in the pathogenesis of lupus.

Muller S, Radic M

Nat. Med.. 2016 Feb;22(2):126-7

Autoantibodies against Modified Histone Peptides in SLE Patients Are Associated with Disease Activity and Lupus Nephritis.

Dieker J, Berden JH, Bakker M, Briand JP, Muller S, Voll R, Sjöwall C, Herrmann M, Hilbrands LB, van der Vlag J

PLoS ONE. 2016 ;11(10):e0165373

Nanomaterials, Autophagy, and Lupus Disease.

Bianco A, Muller S

ChemMedChem. 2016 Jan;11(2):166-74

Targeting VEGF-A with a vaccine decreases inflammation and joint destruction in experimental arthritis.

Semerano L, Duvallet E, Belmellat N, Marival N, Schall N, Monteil M, Grouard-Vogel G, Bernier E, Lecouvey M, Hlawaty H, Muller S, Boissier MC, Assier E

Angiogenesis. 2016 Jan;19(1):39-52

Citrullinated Autoantigens: From Diagnostic Markers to Pathogenetic Mechanisms.

Muller S, Radic M

Clin Rev Allergy Immunol. 2015 Oct;49(2):232-9

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

de Angelis MH, Nicholson G, Selloum M, White J, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, Bedu E, Bekeredjian R, Birling MC, Blake A, Bottomley J, Bowl M, Brault V, Busch DH, Bussell JN, Calzada-Wack J, Cater H, Champy MF, Charles P, Chevalier C, Chiani F, Codner GF, Combe R, Cox R, Dalloneau E, Dierich A, Di Fenza A, Doe B, Duchon A, Eickelberg O, Esapa CT, El Fertak L, Feigel T, Emelyanova I, Estabel J, Favor J, Flenniken A, Gambadoro A, Garrett L, Gates H, Gerdin AK, Gkoutos G, Greenaway S, Glasl L, Goetz P, Da Cruz IG, Götz A, Graw J, Guimond A, Hans W, Hicks G, Hölter SM, Höfler H, Hancock JM, Hoehndorf R, Hough T, Houghton R, Hurt A, Ivandic B, Jacobs H, Jacquot S, Jones N, Karp NA, Katus HA, Kitchen S, Klein-Rodewald T, Klingenspor M, Klopstock T, Lalanne V, Leblanc S, Lengger C, le Marchand E, Ludwig T, Lux A, McKerlie C, Maier H, Mandel JL, Marschall S, Mark M, Melvin DG, Meziane H, Micklich K, Mittelhauser C, Monassier L, Moulaert D, Muller S, Naton B, Neff F, Nolan PM, Nutter LM, Ollert M, Pavlovic G, Pellegata NS, Peter E, Petit-Demoulière B, Pickard A, Podrini C, Potter P, Pouilly L, Puk O, Richardson D, Rousseau S, Quintanilla-Fend L, Quwailid MM, Racz I, Rathkolb B, Riet F, Rossant J, Roux M, Rozman J, Ryder E, Salisbury J, Santos L, Schäble KH, Schiller E, Schrewe A, Schulz H, Steinkamp R, Simon M, Stewart M, Stöger C, Stöger T, Sun M, Sunter D, Teboul L, Tilly I, Tocchini-Valentini GP, Tost M, Treise I, Vasseur L, Velot E, Vogt-Weisenhorn D, Wagner C, Walling A, Weber B, Wendling O, Westerberg H, Willershäuser M, Wolf E, Wolter A, Wood J, Wurst W, Yildirim AÖ, Zeh R, Zimmer A, Zimprich A, ,Holmes C, Steel KP, Herault Y, Gailus-Durner V, Mallon AM, Brown SD

Nat. Genet.. 2015 Sep;47(9):969-978

OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.

Jacquemin C, Schmitt N, Contin-Bordes C, Liu Y, Narayanan P, Seneschal J, Maurouard T, Dougall D, Davizon ES, Dumortier H, Douchet I, Raffray L, Richez C, Lazaro E, Duffau P, Truchetet ME, Khoryati L, Mercié P, Couzi L, Merville P, Schaeverbeke T, Viallard JF, Pellegrin JL, Moreau JF, Muller S, Zurawski S, Coffman RL, Pascual V, Ueno H, Blanco P

Immunity. 2015 Jun;42(6):1159-70

Resetting the autoreactive immune system with a therapeutic peptide in lupus.

Schall N, Muller S

Lupus. 2015 Apr;24(4-5):412-8

Manipulating autophagic processes in autoimmune diseases: a special focus on modulating chaperone-mediated autophagy, an emerging therapeutic target.

Wang F, Muller S

Front Immunol. 2015 ;6:252

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