Fiche personne
Territoire
Alsace
Statut
Enseignant-Chercheur
Équipes/plateformes
CNRS UMR 7504 - Equipe "Chimie des Matériaux Inorganiques (DCMI) / Nanoparticules fonctionnalisées"
Projets
Validation préclinique de nouvelles stratégies thérapeutiques dans le mélanome choroïdien
2014 - Porteur du projet : Pr BEGIN-COLIN Sylvie
Publications
Comparative Influence of Dendron and Dicarboxylate Coatings on the Hyperthermia Performances of Cubic and Spherical Magnetic Nanoparticles.
Iacovita C, Lucaciu CM, Freis B, Kiefer C, Bégin-Colin S
Int J Mol Sci. 2025 09 24;26(19):
In vitro and in vivo validation studies of optimized iron oxide nanoparticles carrying targeting ligands for a new therapeutic strategy in head and neck cancers
Furgiuele S, Gevart T, Freis B, Ramirez MLA, Descamps G, Boutry S, Larbanoix L, Sant'Angelo D, Trelcat A, Saussez S, Bégin-Colin S, Journe F, Laurent S
Nanoscale Adv. 2025 09 3;:
Densification-Related Optical and Photodetection Properties of Green-Synthesized MAPbI and MAPbI@Graphite Powders.
Cai Y, Pirzado AAA, Begin D, Leuvrey C, Khan S, Fix T, Schaller RD, Sanchez C, Begin-Colin S
ACS Omega. 2025 09 2;10(34):38540-38554
Introduction to theranostic nanoplatforms for biomedicine.
Begin S, Laurent S, Pellegrino T, Thanh NTK
Nanoscale. 2025 08 20;:
Polycyclic aromatic hydrocarbons in water environments: Impact, legislation, depollution processes and challenges, and magnetic iron oxide/graphene-based nanocomposites as promising adsorbent solutions.
Vaz-Ramos J, Le Calvé S, Begin S
J Hazard Mater. 2025 02 24;490:137726
Tailoring Nanodiamonds for High-Contrast EPR Imaging: Size, Surface Properties, and Spectroscopic Performance.
Garifo S, Stanicki D, Vangijzegem T, Mellet P, Girard HA, Arnault JC, Bégin-Colin S, Frapart YM, Muller RN, Laurent S
Langmuir. 2025 02 10;:
Spacer engineering in nanoparticle-peptide conjugates boosts targeting specificity for tumor-associated antigens.
Ramírez MLA, Bou-Gharios J, Freis B, Draussin J, Cheignon C, Charbonnière LJ, Laurent S, Gevart T, Gasser A, Jung S, Rossetti F, Tillement O, Noel G, Pivot X, Detappe A, Bégin-Colin S, Harlepp S
Nanoscale. 2025 02 4;:
Defects or no defects? Or how to design 20-25 nm spherical iron oxide nanoparticles to harness both magnetic hyperthermia and photothermia.
Freis B, Kiefer C, Ramirez MLA, Harlepp S, Mertz D, Pichon B, Iacovita C, Laurent S, Begin S
Nanoscale. 2024 10 18;:
Tailoring the pore structure of iron oxide core@stellate mesoporous silica shell nanocomposites: effects on MRI and magnetic hyperthermia properties and applicability to anti-cancer therapies.
Bizeau J, Journaux-Duclos J, Kiefer C, Freis B, Ihiawakrim D, Ramirez MLA, Lucante T, Parkhomenko K, Vichery C, Carrey J, Sandre O, Bertagnolli C, Ersen O, Bégin-Colin S, Gigoux V, Mertz D
Nanoscale. 2024 08 6;:
Magnetic anisotropy engineering in onion-structured metal oxide nanoparticles combining dual exchange coupling and proximity effects.
Sartori K, Lopez-Martin R, Choueikani F, Gloter A, Grenèche JM, Begin-Colin S, Taverna D, De Toro JA, Pichon BP
Nanoscale Adv. 2024 05 29;6(11):2903-2918
A special issue dedicated to the 2022 meeting of the French Society for Nanomedicine.
Sancey L, Corvis Y, Begin-Colin S, Tsapis N
Int J Pharm. 2024 03 14;:124006
Grafting of Crown Ether and Cryptand Macrocycles on Large Pore Stellate Mesoporous Silica for Sodium Cation Extraction.
Duenas-Ramirez P, Bertagnolli C, Weiss R, Bizeau J, Jierry L, Choquet P, Zaloszyc A, Bégin-Colin S, Mertz D
Molecules. 2023 06 7;28(12):
Effect of the Size and Shape of Dendronized Iron Oxide Nanoparticles Bearing a Targeting Ligand on MRI, Magnetic Hyperthermia, and Photothermia Properties-From Suspension to In Vitro Studies.
Freis B, Ramirez MLA, Kiefer C, Harlepp S, Iacovita C, Henoumont C, Affolter-Zbaraszczuk C, Meyer F, Mertz D, Boos A, Tasso M, Furgiuele S, Journe F, Saussez S, Bégin-Colin S, Laurent S
Pharmaceutics. 2023 03 30;15(4):
Phosphate Capture Enhancement Using Designed Iron Oxide-Based Nanostructures.
Ramirez PD, Lee C, Fedderwitz R, Clavijo AR, Barbosa DPP, Julliot M, Vaz-Ramos J, Begin D, Le Calvé S, Zaloszyc A, Choquet P, Soler MAG, Mertz D, Kofinas P, Piao Y, Begin-Colin S
Nanomaterials (Basel). 2023 02 1;13(3):
Bioconjugation studies of an EGF-R targeting ligand on dendronized iron oxide nanoparticles to target head and neck cancer cells.
Freis B, De Los Ángeles Ramírez M, Furgiuele S, Journe F, Cheignon C, Charbonnière LJ, Henoumont C, Kiefer C, Mertz D, Affolter-Zbaraszczuk C, Meyer F, Saussez S, Laurent S, Tasso M, Bégin-Colin S
Int J Pharm. 2023 01 28;:122654
Protein sustained release from isobutyramide-grafted stellate mesoporous silica nanoparticles.
Bizeau J, Adam A, Nadal C, Francius G, Siniscalco D, Pauly M, Bégin-Colin S, Mertz D
Int J Pharm X. 2022 12;4:100130
In situ liquid transmission electron microscopy reveals self-assembly-driven nucleation in radiolytic synthesis of iron oxide nanoparticles in organic media
Ortiz Peña N, Ihiawakrim D, Creţu S, Cotin G, Kiefer C, Begin-Colin S, Sanchez C, Portehault D, Ersen O
Nanoscale. 2022 07 20;:
Magnetic bioactive glass nano-heterostructures: a deeper insight into magnetic hyperthermia properties in the scope of bone cancer treatment.
Vergnaud F, Kesse X, Jacobs A, Perton F, Begin-Colin S, Mertz D, Descamps S, Vichery C, Nedelec JM
Biomater Sci. 2022 06 20;:
A Confinement-Driven Nucleation Mechanism of Metal Oxide Nanoparticles Obtained via Thermal Decomposition in Organic Media.
Cotin G, Heinrich B, Perton F, Kiefer C, Francius G, Mertz D, Freis B, Pichon B, Strub JM, Cianférani S, Ortiz Peña N, Ihiawakrim D, Portehault D, Ersen O, Khammari A, Picher M, Banhart F, Sanchez C, Begin-Colin S
Small. 2022 Apr 15;:e2200414
Core-shell iron oxide@stellate mesoporous silica for combined nearinfrared photothermia and drug delivery: influence of pH and surface chemistry
Adam A, Harlepp S, Ghilini F, Cotin G, Freis B, Goetz J, Begin-Colin S, Tasso M, Mertz D
Colloids Surf. A: Physicochem. Eng. Asp.. 2022 ;640:128407
Assessing the parameters modulating optical losses of iron oxide nanoparticles under near infrared irradiation.
Lozano-Pedraza C, Plaza-Mayoral E, Espinosa A, Sot B, Serrano A, Salas G, Blanco-Andujar C, Cotin G, Felder-Flesch D, Begin-Colin S, Teran FJ
Nanoscale Adv. 2021 11 9;3(22):6490-6502
Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications.
Cotin G, Blanco-Andujar C, Perton F, Asín L, de la Fuente JM, Reichardt W, Schaffner D, Ngyen DV, Mertz D, Kiefer C, Meyer F, Spassov S, Ersen O, Chatzidakis M, Botton GA, Hénoumont C, Laurent S, Greneche JM, Teran FJ, Ortega D, Felder-Flesch D, Begin-Colin S
Nanoscale. 2021 Sep 2;13(34):14552-14571
Iron Stearate Structures: An Original Tool for Nanoparticles Design.
Perton F, Cotin G, Kiefer C, Strub JM, Cianferani S, Greneche JM, Parizel N, Heinrich B, Pichon B, Mertz D, Begin-Colin S
Inorg Chem. 2021 Aug 2;:
Small iron oxide nanoparticles as MRI contrast agent: scalable inexpensive water-based synthesis using a flow reactor.
Besenhard MO, Panariello L, Kiefer C, LaGrow AP, Storozhuk L, Perton F, Begin S, Mertz D, Thanh NTK, Gavriilidis A
Nanoscale. 2021 May 20;13(19):8795-8805
A Detailed Investigation of the Onion Structure of Exchanged Coupled Magnetic FeO@CoFeO@FeO Nanoparticles.
Sartori K, Musat A, Choueikani F, Grenèche JM, Hettler S, Bencok P, Begin-Colin S, Steadman P, Arenal R, Pichon BP
ACS Appl Mater Interfaces. 2021 Mar 29;:
Orienting the Pore Morphology of Core-Shell Magnetic Mesoporous Silica with the Sol-Gel Temperature. Influence on MRI and Magnetic Hyperthermia Properties.
Adam A, Parkhomenko K, Duenas-Ramirez P, Nadal C, Cotin G, Zorn PE, Choquet P, Bégin-Colin S, Mertz D
Molecules. 2021 Feb 12;26(4):
Elaboration of superparamagnetic and bioactive multicore-shell nanoparticles (γ-FeO@SiO-CaO): a promising material for bone cancer treatment.
Kesse X, Adam A, Begin-Colin S, Mertz D, Larquet E, Gacoin T, Maurin I, Vichery C, Nedelec JM
ACS Appl Mater Interfaces. 2020 Sep 29;:
Highly chelating stellate mesoporous silica nanoparticles for specific iron removal from biological media.
Duenas-Ramirez P, Bertagnolli C, Müller R, Sartori K, Boos A, Elhabiri M, Bégin-Colin S, Mertz D
J Colloid Interface Sci. 2020 Jun 7;579:140-151
Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications
Mertz D, Harlepp S, Goetz JG, Bégin D, Schlatter G, Bégin‐Colin S, Hébraud A
. 2020 ;3(2):1900143
Near Infra-Red Light Responsive Carbon Nanotubes@Mesoporous Silica for Photothermia and Drug Delivery to Cancer Cells
Li B, Harlepp S, Gensbittel V, Wells CJR, Bringel O, Goetz JG, Begin-Colin S, Tasso M, Begin D, Mertz D
. 2020 ;17:100308
Metronidazole-functionalized iron oxide nanoparticles for molecular detection of hypoxic tissues.
Filippi M, Nguyen DV, Garello F, Perton F, Bégin-Colin S, Felder-Flesch D, Power L, Scherberich A
Nanoscale. 2019 Nov 20;:
Doxorubicin Loaded Thermo-responsive Superparamagnetic Nanocarriers for Controlled Drug Delivery and Magnetic Hyperthermia Applications.
Ferjaoui Z, Jamal Al Dine E, Jandayeva A, Bezdetnaya L, Soon Chang C, Schneider R, Mutelet F, Mertz D, Begin-Colin S, Quilès F, Gaffet E, Alem H
ACS Appl Mater Interfaces. 2019 Jul 30;:
Strong interfacial coupling through exchange interactions in soft/hard core-shell nanoparticles as a function of cationic distribution.
Sartori K, Cotin G, Bouillet C, Halté V, Bégin-Colin S, Choueikani F, Pichon BP
Nanoscale. 2019 Jul 1;:
Dendron based antifouling, MRI and magnetic hyperthermia properties of different shaped iron oxide nanoparticles.
Cotin G, Blanco-Andujar C, Nguyen DV, Affolter-Zbaraszczuk C, Boutry S, Boos A, Ronot P, Uring B, Choquet P, Zorn PE, Mertz D, Laurent S, Muller RN, Meyer F, Felder-Flesch D, Begin S
Nanotechnology. 2019 Jun 13;:
Wrapped stellate silica nanocomposites as biocompatible luminescent nanoplatforms assessed in vivo.
Perton F, Harlepp S, Follain G, Parkhomenko K, Goetz JG, Bégin-Colin S, Mertz D
J Colloid Interface Sci. 2019 Jan 23;542:469-482
Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model.
Ménard M, Meyer F, Affolter-Zbaraszczuk C, Rabineau M, Adam A, Duenas-Ramirez P, Begin-Colin S, Mertz D
Nanotechnology. 2019 Jan 14;:
Magnetite- and Iodine-Containing Nanoemulsion as a Dual Modal Contrast Agent for X-ray/Magnetic Resonance Imaging.
Wallyn J, Anton N, Mertz D, Begin-Colin S, Perton F, Serra CA, Franconi F, Lemaire L, Chiper M, Libouban H, Messaddeq N, Anton H, Vandamme TF
ACS Appl Mater Interfaces. 2019 Jan 9;11(1):403-416
Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions.
Shi D, Wallyn J, Nguyen DV, Perton F, Felder-Flesch D, Bégin-Colin S, Maaloum M, Krafft MP
Beilstein J Nanotechnol. 2019 ;10:2103-2115
Mesoporous silica templated-albumin nanoparticles with high doxorubicin payload for drug delivery assessed with a 3-D tumor cell model.
Ménard M, Meyer F, Parkhomenko K, Leuvrey C, Francius G, Bégin-Colin S, Mertz D
Biochim Biophys Acta Gen Subj. 2018 Nov 1;:
Unravelling the Thermal Decomposition Parameters for The Synthesis of Anisotropic Iron Oxide Nanoparticles.
Cotin G, Kiefer C, Perton F, Ihiawakrim D, Blanco-Andujar C, Moldovan S, Lefevre C, Ersen O, Pichon B, Mertz D, Bégin-Colin S
Nanomaterials (Basel). 2018 Oct 29;8(11):
Iron Oxide Colloidal Nanoclusters as Theranostic Vehicles and Their Interactions at the Cellular Level.
Kostopoulou A, Brintakis K, Fragogeorgi E, Anthousi A, Manna L, Begin-Colin S, Billotey C, Ranella A, Loudos G, Athanassakis I, Lappas A
Nanomaterials (Basel). 2018 May 9;8(5):
Design of Protein-Coated Carbon Nanotubes Loaded with Hydrophobic Drugs through Sacrificial Templating of Mesoporous Silica Shells.
Fiegel V, Harlepp S, Begin-Colin S, Begin D, Mertz D
Chemistry. 2018 Mar 26;24(18):4662-4670
Evaluation of the Active Targeting of Melanin Granules after Intravenous Injection of Dendronized Nanoparticles.
Bordeianu C, Parat A, Piant S, Walter A, Zbaraszczuk-Affolter C, Meyer F, Begin-Colin S, Boutry S, Muller RN, Jouberton E, Chezal JM, Labeille B, Cinotti E, Perrot JL, Miot-Noirault E, Laurent S, Felder-Flesch D
Mol. Pharm.. 2018 Feb 5;15(2):536-547
How a grafting anchor tailors the cellular uptake and in vivo fate of dendronized iron oxide nanoparticles.
Bordeianu C, Parat A, Affolter-Zbaraszczuk C, Muller RN, Boutry S, Begin-Colin S, Meyer F, Laurent S, Felder-Flesch D
J Mater Chem B. 2017 Jul 14;5(26):5152-5164
Drug releasing nanoplatforms activated by alternating magnetic fields.
Mertz D, Sandre O, Bégin-Colin S
Biochim. Biophys. Acta. 2017 06;1861(6):1617-1641
Effect of the Functionalization Process on the Colloidal, Magnetic Resonance Imaging, and Bioelimination Properties of Mono- or Bisphosphonate-Anchored Dendronized Iron Oxide Nanoparticles.
Walter A, Garofalo A, Bonazza P, Meyer F, Martinez H, Fleutot S, Billotey C, Taleb J, Felder-Flesch D, Begin-Colin S
Chempluschem. 2017 Apr;82(4):647-659
Intracellular degradation of functionalized carbon nanotube/iron oxide hybrids is modulated by iron via Nrf2 pathway.
Elgrabli D, Dachraoui W, Marmier H, Ménard-Moyon C, Bégin D, Bégin-Colin S, Bianco A, Alloyeau D, Gazeau F
Sci Rep. 2017 Jan 25;7:40997
Synthesis engineering of iron oxide raspberry-shaped nanostructures.
Gerber O, Pichon BP, Ihiawakrim D, Florea I, Moldovan S, Ersen O, Begin D, Grenèche JM, Lemonnier S, Barraud E, Begin-Colin S
Nanoscale. 2017 Jan 7;9(1):305-313
Preparation of core/shell NaYF:Yb,Tm@dendrons nanoparticles with enhanced upconversion luminescence for in vivo imaging.
Francolon N, Boyer D, Leccia F, Jouberton E, Walter A, Bordeianu C, Parat A, Felder-Flesch D, Begin-Colin S, Miot-Noirault E, Chezal JM, Mahiou R
Nanomedicine. 2016 10;12(7):2107-2113
Design of iron oxide-based nanoparticles for MRI and magnetic hyperthermia.
Blanco-Andujar C, Walter A, Cotin G, Bordeianu C, Mertz D, Felder-Flesch D, Begin-Colin S
Nanomedicine (Lond). 2016 07;11(14):1889-910
Enhanced Collective Magnetic Properties in 2D Monolayers of Iron Oxide Nanoparticles Favored by Local Order and Local 1D Shape Anisotropy.
Toulemon D, Liu Y, Cattoën X, Leuvrey C, Bégin-Colin S, Pichon BP
Langmuir. 2016 Feb 16;32(6):1621-8
Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents.
Hachani R, Lowdell M, Birchall M, Hervault A, Mertz D, Begin-Colin S, Thanh NT
Nanoscale. 2016 Feb 14;8(6):3278-87
Development and applications of a DNA labeling method with magnetic nanoparticles to study the role of horizontal gene transfer events between bacteria in soil pollutant bioremediation processes.
Pivetal J, Frénéa-Robin M, Haddour N, Vézy C, Zanini LF, Ciuta G, Dempsey NM, Dumas-Bouchiat F, Reyne G, Bégin-Colin S, Felder-Flesh D, Ghobril C, Pourroy G, Simonet P
Environ Sci Pollut Res Int. 2015 Dec;22(24):20322-7
Carbon Nanotube Degradation in Macrophages: Live Nanoscale Monitoring and Understanding of Biological Pathway.
Elgrabli D, Dachraoui W, Ménard-Moyon C, Liu XJ, Bégin D, Bégin-Colin S, Bianco A, Gazeau F, Alloyeau D
ACS Nano. 2015 Oct 27;9(10):10113-24
Selective Nanotrench Filling by One-Pot Electroclick Self-Constructed Nanoparticle Films.
Rydzek G, Toulemon D, Garofalo A, Leuvrey C, Dayen JF, Felder-Flesch D, Schaaf P, Jierry L, Begin-Colin S, Pichon BP, Boulmedais F
Small. 2015 Sep;11(36):4638-42
Towards nanoprinting with metals on graphene.
Melinte G, Moldovan S, Hirlimann C, Liu X, Bégin-Colin S, Bégin D, Banhart F, Pham-Huu C, Ersen O
Nat Commun. 2015 Aug 28;6:8071
Validation of a dendron concept to tune colloidal stability, MRI relaxivity and bioelimination of functional nanoparticles.
Walter A, Garofalo A, Parat A, Jouhannaud J, Pourroy G, Voirin E, Laurent S, Bonazza P, Taleb J, Billotey C, Vander Elst L, Muller RN, Begin-Colin S, Felder-Flesch D
J Mater Chem B. 2015 Feb 28;3(8):1484-1494
Dendrimer-nanoparticle conjugates in nanomedicine.
Parat A, Bordeianu C, Dib H, Garofalo A, Walter A, Bégin-Colin S, Felder-Flesch D
Nanomedicine (Lond). 2015 ;10(6):977-92
Multifunctional carbon nanohorn complexes for cancer treatment.
Chechetka SA, Pichon B, Zhang M, Yudasaka M, Bégin-Colin S, Bianco A, Miyako E
Chem Asian J. 2015 Jan;10(1):160-5
Design of covalently functionalized carbon nanotubes filled with metal oxide nanoparticles for imaging, therapy, and magnetic manipulation.
Liu X, Marangon I, Melinte G, Wilhelm C, Ménard-Moyon C, Pichon BP, Ersen O, Aubertin K, Baaziz W, Pham-Huu C, Bégin-Colin S, Bianco A, Gazeau F, Bégin D
ACS Nano. 2014 Nov 25;8(11):11290-304
Two dimensional dipolar coupling in monolayers of silver and gold nanoparticles on a dielectric substrate.
Liu Y, Begin-Colin S, Pichon BP, Leuvrey C, Ihiawakrim D, Rastei M, Schmerber G, Vomir M, Bigot JY
Nanoscale. 2014 Oct 21;6(20):12080-8
Endowing carbon nanotubes with superparamagnetic properties: applications for cell labeling, MRI cell tracking and magnetic manipulations.
Lamanna G, Garofalo A, Popa G, Wilhelm C, Bégin-Colin S, Felder-Flesch D, Bianco A, Gazeau F, Ménard-Moyon C
Nanoscale. 2013 May 21;5(10):4412-21
