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Coordonnées
Institut de Recherche sur les Maladies Virales et Hépatiques
3 rue Koeberlé
67000 STRASBOURG
03 68 85 37 15
Territoire
Alsace
Statut
Chercheur
Affiliation
Institut de recherche en médecine translationnelle et maladies hépatiques / Inserm UMR_S 1110 (ITM)
Équipes/plateformes
UMR_S 1110 - Equipe "Signalisation et interactions virus-hôte"
Projets
HCV-induced epigenetic regulation of the tumor supressor PTPRD
2017 - Porteur du projet : Dr LUPBERGER Joachim
Publications
Chemoprevention of hepatocellular carcinoma by next-generation antipsychotic aripiprazole.
Slović N, Mishra S, Paul S, Oudot MA, Jühling F, Kanzaki H, Moehlin J, Charlot A, Denos M, Durand SC, Katz C, Gadenne C, Felli E, Ono A, Oka S, Higashi T, Nakagawa S, Akuta N, Goossens N, Chayama K, Lupberger J, Crouchet E, Hoshida Y, Baumert TF
Hepatology. 2026 03 13;:
HDV sensing drives USP18-mediated refractoriness to IFN-α response, sparing IFN-β/λ in hepatocytes.
Eber C, Fouillé R, Moehlin J, Juehling F, Casetta P, Chabot E, Bach C, Schuster C, Baumert TF, Lupberger J, Durantel D, Lucifora J, Verrier ER
Antiviral Res. 2026 03 13;:106395
Hepatitis D Virus Pathogenesis: A Sense of Complications.
Haennel Y, Baumert TF, Lupberger J
Viruses. 2026 02 24;18(3):
Hepatitis B virus-infected hepatocytes promote the secretion of collagen VI to the extracellular matrix.
Virzì A, Boulahtouf Z, Moehlin J, Girard L, Meiss-Heydmann L, Bach C, Gerges E, Durand SC, Oudot MA, Roca Suarez AA, Popp O, Ramberger E, Mertins P, Felli E, Pessaux P, Schuster C, Verrier ER, Baumert TF, Lupberger J
Sci Rep. 2025 07 10;15(1):24949
Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease.
Roca Suarez AA, Jühling F, Moehlin J, Mailly L, Virzì A, Brignon N, Durand SC, Oudot MA, Schaeffer E, Martin R, Meiss-Heydmann L, Bach C, Boulahtouf Z, Girard L, Osswald E, Jamey C, Brumaru D, Dali-Youcef N, Mukherji A, Saez-Palma M, Testoni B, Zoulim F, Koneru B, Fujiwara N, Hoshida Y, Felli E, Pessaux P, Tremblay ML, Parent R, Schuster C, Baumert TF, Lupberger J
eGastroenterology. 2025 01;3(1):e100159
An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection.
Mukherji A, Jühling F, Simanjuntak Y, Crouchet E, Del Zompo F, Teraoka Y, Haller A, Baltzinger P, Paritala S, Rasha F, Fujiwara N, Gadenne C, Slovic N, Oudot MA, Durand SC, Ponsolles C, Schuster C, Zhuang X, Holmes J, Yeh ML, Abe-Chayama H, Heikenwälder M, Sangiovanni A, Iavarone M, Colombo M, Foung SKH, McKeating JA, Davidson I, Yu ML, Chung RT, Hoshida Y, Chayama K, Lupberger J, Baumert TF
Nat Commun. 2024 08 29;15(1):7486
Targeting the liver clock improves fibrosis by restoring TGF-β signaling.
Crouchet E, Dachraoui M, Jühling F, Roehlen N, Oudot MA, Durand SC, Ponsolles C, Gadenne C, Meiss-Heydmann L, Moehlin J, Martin R, Brignon N, Del Zompo F, Teraoka Y, Aikata H, Abe-Chayama H, Chayama K, Saviano A, Heide D, Onea M, Geyer L, Wolf T, Felli E, Pessaux P, Heikenwälder M, Chambon P, Schuster C, Lupberger J, Mukherji A, Baumert TF
J Hepatol. 2024 08 20;:
Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension.
Petrenko O, Königshofer P, Brusilovskaya K, Hofer BS, Bareiner K, Simbrunner B, Jühling F, Baumert TF, Lupberger J, Trauner M, Kauschke SG, Pfisterer L, Simon E, Rendeiro AF, de Rooij LPMH, Schwabl P, Reiberger T
iScience. 2024 03 15;27(3):109301
Inflammation-related prognostic markers in resected hepatocellular carcinoma.
Giannone F, Slovic N, Pessaux P, Schuster C, Baumert TF, Lupberger J
Front Oncol. 2023 12 7;13:1267870
Memories of Stress: The Imprinted Cancer Risk After HCV Cure.
Lupberger J, Baumert TF
Cell Mol Gastroenterol Hepatol. 2023 06 1;:
A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity.
Roehlen N, Saviano A, El Saghire H, Crouchet E, Nehme Z, Del Zompo F, Jühling F, Oudot MA, Durand SC, Duong FHT, Cherradi S, Gonzalez Motos V, Almeida N, Ponsolles C, Heydmann L, Ostyn T, Lallement A, Pessaux P, Felli E, Cavalli A, Sgrignani J, Thumann C, Koutsopoulos O, Fuchs BC, Hoshida Y, Hofmann M, Vyberg M, Viuff BM, Galsgaard ED, Elson G, Toso A, Meyer M, Iacone R, Schweighoffer T, Teixeira G, Moll S, De Vito C, Roskams T, Davidson I, Heide D, Heikenwälder M, Zeisel MB, Lupberger J, Mailly L, Schuster C, Baumert TF
Sci Transl Med. 2022 12 21;14(676):eabj4221
Treatment of HCC with Claudin-1 specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment.
Roehlen N, Muller M, Nehme Z, Crouchet E, Jühling F, Del Zompo F, Cherradi S, Duong FHT, Almeida N, Saviano A, Fernández-Vaquero M, Riedl T, El Saghire H, Durand SC, Ponsolles C, Oudot MA, Martin R, Brignon N, Felli E, Pessaux P, Lallement A, Davidson I, Bandiera S, Thumann C, Marchand P, Moll S, Nicolay B, Bardeesy N, Hoshida Y, Heikenwälder M, Iacone R, Toso A, Meyer M, Elson G, Schweighoffer T, Teixeira G, Zeisel MB, Laquerriere P, Lupberger J, Schuster C, Mailly L, Baumert TF
J Hepatol. 2022 10 26;:
Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation.
Crouchet E, Li S, Sojoodi M, Bandiera S, Fujiwara N, El Saghire H, Zhu S, Qian T, Rasha FA, Del Zompo F, Barrett SC, Schaeffer E, Oudot MA, Ponsolles C, Durand SC, Ghoshal S, Arora G, Giannone F, Chung RT, Slovic N, Van Renne N, Felli E, Pessaux P, Lupberger J, Pochet N, Schuster C, Tanabe KK, Hoshida Y, Fuchs BC, Baumert TF
JCI Insight. 2022 07 8;7(13):
Safety and antiviral activity of EGFR inhibition by erlotinib in chronic hepatitis C patients: a phase Ib randomized controlled trial.
Saviano A, Habersetzer F, Lupberger J, Simo-Noumbissie P, Schuster C, Doffoël M, Schmidt-Mutter C, Baumert TF
Clin Transl Gastroenterol. 2022 Apr 1;:
Signaling Induced by Chronic Viral Hepatitis: Dependence and Consequences.
Boulahtouf Z, Virzì A, Baumert TF, Verrier ER, Lupberger J
Int J Mol Sci. 2022 Mar 3;23(5):
Conventional and artificial intelligence-based imaging for biomarker discovery in chronic liver disease.
Dana J, Venkatasamy A, Saviano A, Lupberger J, Hoshida Y, Vilgrain V, Nahon P, Reinhold C, Gallix B, Baumert TF
Hepatol Int. 2022 Feb 9;:
GOLT1B Activation in Hepatitis C Virus-Infected Hepatocytes Links ER Trafficking and Viral Replication.
Butterworth J, Gregoire D, Peter M, Roca Suarez AA, Desandré G, Simonin Y, Virzì A, Zine El Aabidine A, Guivarch M, Andrau JC, Bertrand E, Assenat E, Lupberger J, Hibner U
Pathogens. 2021 Dec 31;11(1):
Virus-Induced Risk of Hepatocellular Carcinoma: Recent Progress and Future Challenges.
Lupberger J, Baumert TF
J Clin Med. 2021 Dec 31;11(1):
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.
Crouchet E, Bandiera S, Fujiwara N, Li S, El Saghire H, Fernández-Vaquero M, Riedl T, Sun X, Hirschfield H, Jühling F, Zhu S, Roehlen N, Ponsolles C, Heydmann L, Saviano A, Qian T, Venkatesh A, Lupberger J, Verrier ER, Sojoodi M, Oudot MA, Duong FHT, Masia R, Wei L, Thumann C, Durand SC, González-Motos V, Heide D, Hetzer J, Nakagawa S, Ono A, Song WM, Higashi T, Sanchez R, Kim RS, Bian CB, Kiani K, Croonenborghs T, Subramanian A, Chung RT, Straub BK, Schuppan D, Ankavay M, Cocquerel L, Schaeffer E, Goossens N, Koh AP, Mahajan M, Nair VD, Gunasekaran G, Schwartz ME, Bardeesy N, Shalek AK, Rozenblatt-Rosen O, Regev A, Felli E, Pessaux P, Tanabe KK, Heikenwälder M, Schuster C, Pochet N, Zeisel MB, Fuchs BC, Hoshida Y, Baumert TF
Nat Commun. 2021 Sep 17;12(1):5525
Profibrotic Signaling and HCC Risk during Chronic Viral Hepatitis: Biomarker Development.
Virzì A, Gonzalez-Motos V, Tripon S, Baumert TF, Lupberger J
J Clin Med. 2021 Mar 2;10(5):
Interferon revisited: Peering behind the lines of antiviral defense.
Virzì A, Roca Suarez AA, Lupberger J
J. Hepatol.. 2020 Jul 10;:
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor.
Eller C, Heydmann L, Colpitts CC, El Saghire H, Piccioni F, Jühling F, Majzoub K, Pons C, Bach C, Lucifora J, Lupberger J, Nassal M, Cowley GS, Fujiwara N, Hsieh SY, Hoshida Y, Felli E, Pessaux P, Sureau C, Schuster C, Root DE, Verrier ER, Baumert TF
Nat Commun. 2020 Jun 1;11(1):2707
Imaging-AMARETTO: An Imaging Genomics Software Tool to Interrogate Multiomics Networks for Relevance to Radiography and Histopathology Imaging Biomarkers of Clinical Outcomes.
Gevaert O, Nabian M, Bakr S, Everaert C, Shinde J, Manukyan A, Liefeld T, Tabor T, Xu J, Lupberger J, Haas BJ, Baumert TF, Hernaez M, Reich M, Quintana FJ, Uhlmann EJ, Krichevsky AM, Mesirov JP, Carey V, Pochet N
JCO Clin Cancer Inform. 2020 May;4:421-435
Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip.
Goto K, Roca Suarez AA, Wrensch F, Baumert TF, Lupberger J
Int J Mol Sci. 2020 Apr 26;21(9):
Tight Junction Proteins and the Biology of Hepatobiliary Disease.
Roehlen N, Roca Suarez AA, El Saghire H, Saviano A, Schuster C, Lupberger J, Baumert TF
Int J Mol Sci. 2020 Jan 28;21(3):
Nucleic Acid-Induced Signaling in Chronic Viral Liver Disease.
Roca Suarez AA, Testoni B, Baumert TF, Lupberger J
Front Immunol. 2020 ;11:624034
Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis.
Virzì A, Suarez AAR, Baumert TF, Lupberger J
Cold Spring Harb Perspect Med. 2019 Sep 9;:
Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of HCV-infected Cells and Liver to Identify Pathways Associated With Disease Development.
Lupberger J, Croonenborghs T, Roca Suarez AA, Van Renne N, Jühling F, Oudot MA, Virzì A, Bandiera S, Jamey C, Meszaros G, Brumaru D, Mukherji A, Durand SC, Heydmann L, Verrier ER, El Saghire H, Hamdane N, Bartenschlager R, Fereshetian S, Ramberger E, Sinha R, Nabian M, Everaert C, Jovanovic M, Mertins P, Carr SA, Chayama K, Dali-Youcef N, Ricci R, Bardeesy NM, Fujiwara N, Gevaert O, Zeisel MB, Hoshida Y, Pochet N, Baumert TF
Gastroenterology. 2019 Apr 9;:
HCV-induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.
Hamdane N, Jühling F, Crouchet E, El Saghire H, Thumann C, Oudot MA, Bandiera S, Saviano A, Ponsolles C, Roca Suarez AA, Li S, Fujiwara N, Ono A, Davidson I, Bardeesy N, Schmidl C, Bock C, Schuster C, Lupberger J, Habersetzer F, Doffoël M, Piardi T, Sommacale D, Imamura M, Uchida T, Ohdan H, Aikata H, Chayama K, Boldanova T, Pessaux P, Fuchs BC, Hoshida Y, Zeisel MB, Duong FHT, Baumert TF
Gastroenterology. 2019 Mar 2;:
Oncogenic Signaling Induced by HCV Infection.
Virzì A, Roca Suarez AA, Baumert TF, Lupberger J
Viruses. 2018 Oct 2;10(10):
Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling.
Roca Suarez AA, Baumert TF, Lupberger J
J. Hepatol.. 2018 Jun 21;:
Viral manipulation of STAT3: Evade, exploit, and injure.
Roca Suarez AA, Van Renne N, Baumert TF, Lupberger J
PLoS Pathog.. 2018 Mar;14(3):e1006839
miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.
Van Renne N, Roca Suarez AA, Duong FH, Gondeau C, Calabrese D, Fontaine N, Ababsa A, Bandiera S, Croonenborghs T, Pochet N, De Blasi V, Pessaux P, Piardi T, Sommacale D, Ono A, Chayama K, Fujita M, Nakagawa H, Hoshida Y, Zeisel MB, Heim MH, Baumert TF, Lupberger J
Gut. 2017 Feb;:
Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis.
Colpitts CC, Lupberger J, Baumert TF
Proc. Natl. Acad. Sci. U.S.A.. 2016 Jul;113(27):7298-300
Host cell kinases and the hepatitis C virus life cycle.
Colpitts CC, Lupberger J, Doerig C, Baumert TF
Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1657-62
Claudins and pathogenesis of viral infection.
Tawar RG, Colpitts CC, Lupberger J, El-Saghire H, Zeisel MB, Baumert TF
Semin Cell Dev Biol. 2015 May 7. pii: S1084-9521(15)00097-X
Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody.
Mailly L, Xiao F, Lupberger J, Wilson GK, Aubert P, Duong FH, Calabrese D, Leboeuf C, Fofana I, Thumann C, Bandiera S, Lutgehetmann M, Volz T, Davis C, Harris HJ, Mee CJ, Girardi E, Chane-Woon-Ming B, Ericsson M, Fletcher N, Bartenschlager R, Pessaux P, Vercauteren K, Meuleman P, Villa P, Kaderali L, Pfeffer S, Heim MH, Neunlist M, Zeisel MB, Dandri M, McKeating JA, Robinet E, Baumert TF
Nat Biotechnol. 2015 Mar 23
PI4K-beta and MKNK1 are regulators of hepatitis C virus IRES-dependent translation.
Lupberger J, Casanova C, Fischer B, Weiss A, Fofana I, Fontaine N, Fujiwara T, Renaud M, Kopp A, Schuster C, Brino L, Baumert TF, Thoma C
Sci Rep. 2015 Sep 1;5:13344
CD81-receptor associations--impact for hepatitis C virus entry and antiviral therapies.
Zona L, Tawar RG, Zeisel MB, Xiao F, Schuster C, Lupberger J, Baumert TF
Viruses. 2014 Feb 18;6(2):875-92
Identification and characterization of a novel bipartite nuclear localization signal in the hepatitis B virus polymerase.
Lupberger J, Schaedler S, Peiran A, Hildt E
World J Gastroenterol. 2013 Nov 28;19(44):8000-10
Epidermal growth factor receptor signaling impairs the antiviral activity of interferon-alpha.
Lupberger J, Duong FH, Fofana I, Zona L, Xiao F, Thumann C, Durand SC, Pessaux P, Zeisel MB, Heim MH, Baumert TF
Hepatology. 2013 Oct;58(4):1225-35
Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies.
Fofana I, Zona L, Thumann C, Heydmann L, Durand SC, Lupberger J, Blum HE, Pessaux P, Gondeau C, Reynolds GM, McKeating JA, Grunert F, Thompson J, Zeisel MB, Baumert TF
J Virol. 2013 Sep;87(18):10405-10
Interferon-lambda polymorphisms and hepatitis C virus clearance revisited.
Lupberger J, Felmlee DJ, Baumert TF
Hepatology. 2013 Jul;58(1):439-41
HRas signal transduction promotes hepatitis C virus cell entry by triggering assembly of the host tetraspanin receptor complex.
Zona L, Lupberger J, Sidahmed-Adrar N, Thumann C, Harris HJ, Barnes A, Florentin J, Tawar RG, Xiao F, Turek M, Durand SC, Duong FH, Heim MH, Cosset FL, Hirsch I, Samuel D, Brino L, Zeisel MB, Le Naour F, McKeating JA, Baumert TF
Cell Host Microbe. 2013 Mar 13;13(3):302-13
Host-targeting agents for prevention and treatment of chronic hepatitis C - perspectives and challenges.
Zeisel MB, Lupberger J, Fofana I, Baumert TF
J Hepatol. 2013 Feb;58(2):375-84
Cholesterol uptake and hepatitis C virus entry.
Lupberger J, Felmlee DJ, Baumert TF
J Hepatol. 2012 Jul;57(1):215-7
[Open Sesame: regulation of hepatitis C virus entry into hepatocytes].
Turek M, Lupberger J, Baumert TF, Zeisel MB
Med Sci (Paris). 2011 Nov;27(11):929-31
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoel M, Raffelsberger W, Poch O, McKeating JA, Brino L, Baumert TF
Nat Med. 2011 May;17(5):589-95
Blood loss during transurethral resection of the prostate as measured by the chromium-51 method.
Descazeaud A, Azzousi AR, Ballereau C, Bruyere F, Robert G, Delongchamps NB, Devonec M, Dumonceau O, Fourmarier M, Saussine C, Berger J, de la Taille A, Haillot O
J Endourol. 2010 Nov;24(11):1813-6
Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles.
Benga WJ, Krieger SE, Dimitrova M, Zeisel MB, Parnot M, Lupberger J, Hildt E, Luo G, McLauchlan J, Baumert TF, Schuster C
Hepatology. 2010 Jan;51(1):43-53.
RNAi: a powerful tool to unravel hepatitis C virus-host interactions within the infectious life cycle.
Lupberger J, Brino L, Baumert TF
J Hepatol. 2008 Mar;48(3):523-5
A novel system for efficient gene transfer into primary human hepatocytes via cell-permeable hepatitis B virus-like particle.
Brandenburg B, Stockl L, Gutzeit C, Roos M, Lupberger J, Schwartlander R, Gelderblom H, Sauer IM, Hofschneider PH, Hildt E
Hepatology. 2005 Dec;42(6):1300-9.
