Dr LEBEAU Luc

Fiche personne

Coordonnées

Laboratoire CBST
Faculté de Pharmacie
74 route du Rhin
BP 60024
67401 ILLKIRCH Cedex

03 68 85 43 03

Territoire

Alsace

Statut

Chercheur

Affiliation

Laboratoire de chémo-biologie synthétique & thérapeutique - UMR 7199 (CBST)

Équipes/plateformes

UMR 7199 - Equipe "Nanoparticules intelligentes (NPI)"

Projets

Nanoparticules théranostiques multimodales pour l'oncologie et les thérapies guidées par l'image

2016 - Porteur du projet : Dr LEBEAU Luc

Développement d'un système de délivrance conjointe de drogues anti-tumorales hydrophobes et de produits de thérapie génique pour des applications en oncologie

2015 - Porteur du projet : Dr LEBEAU Luc

Développement de nouveaux vecteurs pH-sensibles pour le ciblage de tissus tumoraux

2013 - Porteur du projet : Dr LEBEAU Luc

Développement de nouveaux vecteurs pH-sensibles pour le ciblage de tissus tumoraux

2012 - Porteur du projet : Dr LEBEAU Luc

Publications

Insights into the structure and evolution of the human SAGA complex by affinity-ligand purification.

Damilot M, Schoeps T, Tora L, Schultz P, Lebeau L, Papai G, Ben-Shem A

Sci Adv. 2026 03 20;12(12):eaec8104

Carbon Dots with Tunable Charge as Mucus-Penetrating Gene Carriers.

Arca S, Witjaksono C, Pons F, Lebeau L

Pharmaceutics. 2025 10 14;17(10):

Involvement of Surface Receptors in the Uptake and Cellular Responses Induced by Cationic Polyamine-Based Carbon Dots in Macrophages.

Cerland A, Harmouch E, Rapp M, Lebeau L, Pons F, Ronzani C

Toxics. 2025 08 30;13(9):

Engineered carbon dots for mucosal gene delivery.

Arca S, Pons F, Lebeau L

Eur J Pharm Sci. 2025 07 30;:107222

The interplay between lysosome, protein corona and biological effects of cationic carbon dots: role of surface charge titratability.

Arezki Y, Harmouch E, Delalande F, Rapp M, Schaeffer-Reiss C, Galli O, Cianférani S, Lebeau L, Pons F, Ronzani C

Int J Pharm. 2023 09 6;:123388

Surface charge influences protein corona, cell uptake and biological effects of carbon dots.

Arezki Y, Delalande F, Schaeffer-Reiss C, Cianférani S, Rapp M, Lebeau L, Pons F, Ronzani C

Nanoscale. 2022 09 28;:

Cationic Carbon Nanoparticles Induce Inflammasome-Dependent Pyroptosis in Macrophages Lysosomal Dysfunction.

Arezki Y, Rapp M, Lebeau L, Ronzani C, Pons F

Front Toxicol. 2022 07 19;4:925399

Mucus-producing epithelial models for investigating the activity of gene delivery systems in the lung.

Sonntag T, Rapp M, Didier P, Lebeau L, Pons F, Casset A

Int J Pharm. 2021 Dec 24;:121423

A Co-Culture Model of the Human Respiratory Tract to Discriminate the Toxicological Profile of Cationic Nanoparticles According to Their Surface Charge Density.

Arezki Y, Cornacchia J, Rapp M, Lebeau L, Pons F, Ronzani C

Toxics. 2021 Aug 31;9(9):

The pH-Induced Specific Area Changes of Unsaturated Lipids Deposited onto a Bubble Interface.

Anton N, Pierrat P, Brou GA, Gbassi GK, Omran Z, Lebeau L, Vandamme TF, Bouriat P

Langmuir. 2021 Feb 12;:

Combined In Vitro and In Vivo Approaches to Propose a Putative Adverse Outcome Pathway for Acute Lung Inflammation Induced by Nanoparticles: A Study on Carbon Dots.

Weiss M, Fan J, Claudel M, Lebeau L, Pons F, Ronzani C

Nanomaterials (Basel). 2021 Jan 13;11(1):

Density of surface charge is a more predictive factor of the toxicity of cationic carbon nanoparticles than zeta potential.

Weiss M, Fan J, Claudel M, Sonntag T, Didier P, Ronzani C, Lebeau L, Pons F

J Nanobiotechnology. 2021 Jan 6;19(1):5

Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs.

Gaillard B, Remy JS, Pons F, Lebeau L

Pharm. Res.. 2020 May 27;37(6):106

rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells.

Meng W, Rey-Rico A, Claudel M, Schmitt G, Speicher-Mentges S, Pons F, Lebeau L, Venkatesan JK, Cucchiarini M

Nanomaterials (Basel). 2020 Apr 28;10(5):

Dual Gene Delivery Reagents From Antiproliferative Alkylphospholipids for Combined Antitumor Therapy.

Gaillard B, Remy JS, Pons F, Lebeau L

Front Chem. 2020 ;8:581260

Erufosine (ErPC3) Cationic Prodrugs as Dual Gene Delivery Reagents for Combined Antitumor Therapy.

Gaillard B, Seguin C, Remy JS, Pons F, Lebeau L

Chemistry. 2019 Sep 24;:

Physicochemical characteristics that affect carbon dot safety: lessons from a comprehensive study on a nanoparticle library.

Fan J, Claudel M, Ronzani C, Arezki Y, Lebeau L, Pons F

Int J Pharm. 2019 Jul 16;:118521

Cationic DOPC-Detergent Conjugates for Safe and Efficient in Vitro and in Vivo Nucleic Acid Delivery.

Pierrat P, Casset A, Didier P, Kereselidze D, Lux M, Pons F, Lebeau L

Chembiochem. 2016 Sep;17(18):1771-83

Enhanced gene delivery to the lung using biodegradable polyunsaturated cationic phosphatidylcholine-detergent conjugates.

Pierrat P, Kereselidze D, Lux M, Lebeau L, Pons F

Int J Pharm. 2016 Sep;511(1):205-18

DOPC-Detergent Conjugates: Fusogenic Carriers for Improved In Vitro and In Vivo Gene Delivery.

Pierrat P, Casset A, Kereselidze D, Lux M, Pons F, Lebeau L

Macromol Biosci. 2016 Jul;16(7):984-9

Characterization of Titratable Amphiphiles in Lipid Membranes by Fluorescence Spectroscopy.

Pierrat P, Lebeau L

Langmuir. 2015 Nov;31(45):12362-71

Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers.

Pierrat P, Wang R, Kereselidze D, Lux M, Didier P, Kichler A, Pons F, Lebeau L

Biomaterials. 2015 May;51:290-302

Bioresponsive deciduous-charge amphiphiles for liposomal delivery of DNA and siRNA.

Pierrat P, Kereselidze D, Wehrung P, Zuber G, Pons F, Lebeau L

Pharm Res. 2013 May;30(5):1362-79

Phospholipid-detergent conjugates as novel tools for siRNA delivery.

Pierrat P, Laverny G, Creusat G, Wehrung P, Strub JM, VanDorsselaer A, Pons F, Zuber G, Lebeau L

Chemistry. 2013 Feb 11;19(7):2344-55

A cationic phospholipid-detergent conjugate as a new efficient carrier for siRNA delivery.

Pierrat P, Creusat G, Laverny G, Pons F, Zuber G, Lebeau L

Chemistry. 2012 Mar 26;18(13):3835-9

Lung deposition and toxicological responses evoked by multi-walled carbon nanotubes dispersed in a synthetic lung surfactant in the mouse.

Ronzani C, Spiegelhalter C, Vonesch JL, Lebeau L, Pons F

Arch Toxicol. 2012 Jan;86(1):137-49

Nucleic acid transfer with hemifluorinated polycationic lipids.

Klein E, Leborgne C, Ciobanu M, Klein J, Frisch B, Pons F, Zuber G, Scherman D, Kichler A, Lebeau L

Biomaterials. 2010 Jun;31(17):4781-8

"HFP" fluorinated cationic lipids for enhanced lipoplex stability and gene delivery.

Klein E, Ciobanu M, Klein J, Machi V, Leborgne C, Vandamme T, Frisch B, Pons F, Kichler A, Zuber G, Lebeau L

Bioconjug Chem. 2010 Feb 17;21(2):360-71.

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