Dr GUIHARD Sébastien

Head and neck radiotherapy after reconstructive flap surgery: Results of the multicentric XFLAP1 study.

Di Rito A, Blache A, Preudhomme R, Lequesne J, James D, Doré M, Mony R, Hily L, Khalladi N, Guihard S, Coutte A, Schick U, Thureau S, Errico A, Beddok A, Calugaru V, Christy F, Thariat J

Radiother Oncol. 2026 05;218:111437

Postoperative SBRT and Severe Late Toxic Effects in Early-Stage Oropharyngeal and Oral Cavity Cancers: The STEREOPOSTOP-GORTEC 2017-03 Nonrandomized Clinical Trial.

Biau J, Sun X, Liem X, Faivre JC, Eker E, Blanchard P, Tao Y, Doré M, Maingon P, Vulquin N, Alfonsi M, Thureau S, Huguet F, Racadot S, Thivat E, Molnar I, Boisselier P, Guihard S, Gallocher O, Dupin C, Batard S, Bourhis J, Lapeyre M

JAMA Netw Open. 2025 12 1;8(12):e2549975

Patterns of relapse after postoperative radiotherapy in patients with oral cavity cancer and a flap.

Blache A, Lequesne J, Christy F, Preudhomme R, James D, Doré M, Mony R, Hily L, Khalladi N, Guihard S, Di Rito A, Coutte A, Beddok A, Thariat J

Cancer Radiother. 2025 05 23;29(3):104642

Prediction of the need of enteral nutrition during radiation therapy for head and neck cancers.

Giraud P, Guihard S, Thureau S, Guilbert P, Ruffier A, Eugene R, Lamrani-Ghaouti A, Chargari C, Liem X, Bibault JE

Radiother Oncol. 2024 12 21;:110693

Survival without Quality of Life Deterioration in the GORTEC 2014-04 "OMET" Randomised Phase 2 Trial in Head and Neck Cancer Patients with Oligometastases using Stereotactic Ablative Radiotherapy (SABR)-alone or chemotherapy SABR.

Thariat J, Bosset M, Falcoz A, Vernerey D, Pointreau Y, Racadot S, Faivre JC, Castelli J, Guihard S, Huguet F, Chapet S, Tao Y, Borel C, Fayette J, Rambeau A, Ferrand FR, Pechery A, Bourhis J, Sun XS

Int J Radiat Oncol Biol Phys. 2024 11 27;:

Cost-effectiveness of weekly adaptive radiotherapy versus standard IMRT in head and neck cancer alongside the ARTIX trial.

Perrier L, Balusson F, Morelle M, Castelli J, Thariat J, Benezery K, Hasbini A, Gery B, Berger A, Liem X, Guihard S, Chapet S, Thureau S, Auberdiac P, Pommier P, Ruffier A, Devillers A, Oger E, Campillo-Gimenez B, de Crevoisier R

Radiother Oncol. 2024 02 3;:110116

Bayesian Network structure learning algorithm for highly missing and non imputable data: Application to breast cancer radiotherapy data.

Piot M, Bertrand F, Guihard S, Clavier JB, Maumy M

Artif Intell Med. 2024 01;147:102743

[Clinical research in private sector: Which strategic analysis?].

Ruffier A, Pointreau Y, Sacier V, Balavoine M, Lamrani-Ghaouti A, Guihard S, Rivera S

Cancer Radiother. 2023 08 16;:

[Real world data in radiotherapy: A data farming project by Unitrad].

Guihard S, Piot M, Issoufaly I, Giraud P, Bruand M, Faivre JC, Eugène R, Liem X, Pasquier D, Lamrani-Ghaouti A, Ghannam Y, Ruffier A, Guilbert P, Larnaudie A, Thariat J, Rivera S, Clavier JB

Cancer Radiother. 2023 07 28;:

Tumor-Suppressive and Immunomodulating Activity of miR-30a-3p and miR-30e-3p in HNSCC Cells and Tumoroids.

Conrad O, Burgy M, Foppolo S, Jehl A, Thiéry A, Guihard S, Vauchelles R, Jung AC, Mourtada J, Macabre C, Ledrappier S, Chenard MP, Onea MA, Danic A, Dourlhes T, Thibault C, Schultz P, Dontenwill M, Martin S

Int J Mol Sci. 2023 07 6;24(13):

Weekly Adaptive Radiotherapy vs Standard Intensity-Modulated Radiotherapy for Improving Salivary Function in Patients With Head and Neck Cancer: A Phase 3 Randomized Clinical Trial.

Castelli J, Thariat J, Benezery K, Hasbini A, Gery B, Berger A, Liem X, Guihard S, Chapet S, Thureau S, Auberdiac P, Pommier P, Ruffier A, Perrier L, Devillers A, Campillo-Gimenez B, de Crevoisier R

JAMA Oncol. 2023 06 1;:

Acute skin toxicity of conventional fractionated versus hypofractionated radiotherapy in breast cancer patients receiving regional node irradiation: the real-life prospective multicenter HYPOBREAST cohort.

Bruand M, Salleron J, Guihard S, Crety CM, Liem X, Pasquier D, Lamrani-Ghaouti A, Charra-Brunaud C, Peiffert D, Clavier JB, Desandes E, Faivre JC

BMC Cancer. 2022 12 16;22(1):1318

Favorable safety profile of moderate hypofractionated over normofractionated radiotherapy in breast cancer patients: a multicentric prospective real-life data farming analysis.

Issoufaly I, Petit C, Guihard S, Eugène R, Jung L, Clavier JB, Servagi Vernat S, Bellefqih S, Verret B, Bonnet N, Deutsch É, Rivera S

Radiat Oncol. 2022 Apr 20;17(1):80

[Prognostic factors of acute radiodermatitis in breast cancer after adjuvant radiotherapy treated with RT3D or IMRT].

Thomas A, Keller A, Menoux I, Brahimi Y, Vigneron C, Le Fèvre C, Chambrelant I, Pietta GA, Guihard S, Clavier JB, Antoni D, Noël G

Cancer Radiother. 2022 Feb 25;:

A priori quality assurance using a benchmark case of the randomized phase 2 GORTEC 2014-14 in oligometastatic head and neck cancer patients.

Khalladi N, Dejean C, Bosset M, Pointreau Y, Kinj R, Racadot S, Castelli J, Huguet F, Renard S, Guihard S, Tao Y, Rouvier JM, Johnson A, Bourhis J, Xu Shan S, Thariat J

Cancer Radiother. 2021 Sep 23;:

Histosurgical mapping of endoscopic endonasal surgery of sinonasal tumours to improve radiotherapy guidance.

Leleu T, Bastit V, Doré M, Kammerer E, Florescu C, Alfonsi M, Troussier I, Bensadoun RJ, Biau J, Blais E, Coutte A, Deberne M, Wiazzane N, Dupin C, Faivre JC, Giraud P, Graff P, Guihard S, Huguet F, Janoray G, Liem X, Pointreau Y, Racadot S, Schick U, Servagi-Vernat S, Sun XS, Thureau S, Villa J, Vulquin N, Wong S, Patron V, Thariat J

Cancer Radiother. 2021 Jun 23;:

Anxiety during Radiation Therapy: A Prospective Randomized Controlled Trial Evaluating a Specific One-on-One Procedure Announcement Provided by a Radiation Therapist.

Antoni D, Vigneron C, Clavier JB, Guihard S, Velten M, Noel G

Cancers (Basel). 2021 May 24;13(11):

Weekly Paclitaxel, Carboplatin, and Cetuximab as First-Line Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma for Patients Ineligible to Cisplatin-Based Chemotherapy: A Retrospective Monocentric Study in 60 Patients.

Carinato H, Burgy M, Ferry R, Fischbach C, Kalish M, Guihard S, Brahimi Y, Flesch H, Bronner G, Schultz P, Frasie V, Thiéry A, Demarchi M, Petit T, Jung AC, Wagner P, Coliat P, Borel C

Front Oncol. 2021 ;11:714551

Clavier JB, Jung L, Eugène R, Mazzara C, Servagi S, Rivera S, Issoufaly I, Bellefqih S, Hannoun-Lévi JM, Petit C, Feuillade J, Fontbonne JM, Bonnet N, Jou A, Piot M, Liem X, Thariat J, Guihard S

Cancer Radiother. 2020 Oct;24(6-7):774-775

Issoufaly I, Rivera S, Guihard S, Clavier JB, Rémi E, Vigneron C, Menoux I, Mazzara C, Servagi Vernat S, Bellefquih S, Petit C

Cancer Radiother. 2020 Oct;24(6-7):780

Jou A, Guihard S, Fontbonne JM, Clavier JB, Fontbonne C, Mazzara C, Eugène R, Piot M, Jung L, Thariat J

Cancer Radiother. 2020 Oct;24(6-7):780-781

[New concepts of medical consultation in oncology].

Bibault JE, Denis F, Guihard S, Clavier JB, Durdux C, Giraud P, Kreps S, Maaradji S, Dautruche A, Fabiano E, Feutren T, Thariat J

Cancer Radiother. 2020 Aug 1;:

Interest to consider re-challenging by cetuximab and platinum containing regimen in recurrent Head and Neck Cancer.

Borel C, Regnier-Gavier O, Carinato H, Guihard S, Antoni D, Demarchi M, Sirlin F, Exinger D, Petit-Jean E, Thiery A, Bronner G, Schultz P, Flesch H, Frasie V, Prébay D, Petit T, Jung AC, Burgy M, Coliat P

Oncotarget. 2018 Dec 25;9(101):37581-37588

Practical contouring guidelines with an MR-based atlas of brainstem structures involved in radiation-induced nausea and vomiting.

Beddok A, Faivre JC, Coutte A, Guévelou JL, Welmant J, Clavier JB, Guihard S, Janoray G, Calugaru V, Pointreau Y, Lacout A, Salleron J, Lefranc M, Hasboun D, Duvernoy HM, Thariat J

Radiother Oncol. 2018 Aug 29;:

[Radiotherapy of bone metastases in France: A descriptive monocentric retrospective study].

Le Fèvre C, Antoni D, Thiéry A, Keller A, Truntzer P, Vigneron C, Clavier JB, Guihard S, Pop M, Schumacher C, Salze P, Noël G

Cancer Radiother. 2018 Apr;22(2):148-162

[Prognostic factors for head and neck cancer reirradiation: A systematic review].

Ohnleiter T, Truntzer P, Antoni D, Guihard S, Elgard AM, Noël G

Cancer Radiother. 2017 May;:

[Choroidal metastasis from a lung adenocarcinoma treated by intravitreal injection of anti-VEGF and external beam radiotherapy: A case report].

Menoux I, Guihard S, Antoni D, Bijon JC, Noël G

Cancer Radiother. 2017 Mar;:

[Big data and their perspectives in radiation therapy].

Guihard S, Thariat J, Clavier JB

Bull Cancer. 2017 Feb;104(2):147-156

MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma.

Bonnin N, Armandy E, Carras J, Ferrandon S, Battiston-Montagne P, Aubry M, Guihard S, Meyronet D, Foy JP, Saintigny P, Ledrappier S, Jung A, Rimokh R, Rodriguez-Lafrasse C, Poncet D

Oncotarget. 2016 Jul;7(28):44023-44038

[Orodental status before radiation therapy of the head and neck area: A prospective analysis on 48 patients].

Rouers M, Dubourg S, Bornert F, Truntzer P, Antoni D, Couchot J, Ganansia V, Bourrier C, Guihard S, Noël G

Cancer Radiother. 2016 May;20(3):199-204

[Dental state in patients with head and neck cancers].

Rouers M, Truntzer P, Dubourg S, Guihard S, Antoni D, Noel G

Cancer Radiother. 2015 May;19(3):205-10; quiz 230, 234

[Constraints of the dentist are consistent with the results of an optimal irradiation with modulated intensity in N0 oropharyngeal cancer].

Jaussaud S, Guihard S, Niederst C, Borel C, Meyer P, Hemar P, Schultz P, Noel G, Feki A

Cancer Radiother. 2013 Jul-Aug;17(4):265-71

CD8-alpha T-cell infiltration in human papillomavirus-related oropharyngeal carcinoma correlates with improved patient prognosis.

Jung AC, Guihard S, Krugell S, Ledrappier S, Brochot A, Dalstein V, Job S, de Reynies A, Noel G, Wasylyk B, Clavel C, Abecassis J

Int J Cancer. 2013 Jan 15;132(2):E26-36

Early evaluation predicts pain relief of irradiated bone metastases: a single-center prospective study.

Truntzer P, Atlani D, Pop M, Clavier JB, Guihard S, Schumacher C, Noel G

BMC Palliat Care. 2013 Mar 13;12:12

The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation.

Guihard S, Ramolu L, Macabre C, Wasylyk B, Noel G, Abecassis J, Jung AC

Int J Oncol. 2012 Oct;41(4):1531-40

[High-risk human papilloma virus associated oropharynx squamous cell carcinomas: clinical, biological implications and therapeutical perspectives].

Guihard S, Jung AC, Noel G

Cancer Radiother. 2012 Feb;16(1):34-43

[Merkel cell carcinoma, role of radiotherapy and literature review]

Guihard S, Noel G

Cancer Radiother. 2009 Jan;13(1):47-54